Product image of Mannitol Viaflo Baxter (Mannitol) supplied by GNH India

Mannitol Viaflo Baxter

Active Ingredient:
Mannitol
Origin:
EU

Mannitol Viaflo Baxter (Mannitol)

Mannitol, the active ingredient in Mannitol Viaflo Baxter, is an osmotic diuretic presented as a sterile injectable solution for intravenous use. It is employed to lower elevated intracranial pressure, to promote diuresis in acute renal failure, and to aid the renal elimination of certain toxins in hospitalized patients.

GNH India supplies Mannitol Viaflo Baxter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Baxter Slovakia S.R.O.

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Indications & Clinical Uses

Mannitol is used in renal and neurocritical care to manage fluid balance and pressure abnormalities.

  • Reduction of intracranial pressure: lowers cerebral edema and intracranial hypertension.
  • Acute renal failure: increases urine output to support renal clearance.
  • Renal excretion of toxins: enhances elimination of nephrotoxic substances and certain drugs.

How It Works

  • Mannitol raises plasma osmolality by remaining largely extracellular, creating an osmotic gradient that draws water from intracellular and interstitial compartments into the vascular space. This shift expands intravascular volume, promotes renal filtration, and reduces cerebral edema, thereby facilitating diuresis and decreasing intracranial pressure.

Side Effects

Mannitol may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea or vomiting: transient gastrointestinal upset.
  • Electrolyte disturbances: especially hyponatremia or hyperkalemia.
  • Transient hypotension: due to rapid plasma volume expansion.

Serious or Rare Side Effects

  • Acute renal failure: worsening kidney function in susceptible patients.
  • Pulmonary edema: fluid overload in patients with compromised cardiac function.
  • Severe electrolyte imbalance: leading to cardiac arrhythmias.
  • Hemolysis: particularly in patients with G6PD deficiency.
  • Anaphylactoid reactions: rare hypersensitivity with rash or bronchospasm.

Precautions & Warnings

Mannitol should be administered with careful monitoring of fluid status and laboratory parameters.

  • Renal function: assess baseline creatinine and urine output before use.
  • Cardiac status: avoid rapid infusion in patients with heart failure.
  • Electrolytes: monitor serum sodium, potassium, and osmolality regularly.
  • Volume status: adjust infusion rate to prevent fluid overload.
  • Storage: Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Mannitol can alter the pharmacokinetics of several co‑administered agents.

Major Interactions (Avoid)

  • Loop diuretics: may exacerbate electrolyte loss and renal impairment.
  • Nephrotoxic antibiotics (e.g., aminoglycosides): increased risk of renal toxicity.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible additive hypotensive effect.
  • Insulin or oral hypoglycemics: osmotic shifts may affect glucose control.
  • Lithium: altered renal clearance may raise serum lithium levels.

Frequently Asked Questions

Mannitol Viaflo Baxter is an intravenous osmotic diuretic used primarily to lower elevated intracranial pressure, to increase urine output in acute renal failure, and to facilitate the renal elimination of certain toxins. It is administered in hospital settings where rapid fluid shifts are required for therapeutic effect.

Mannitol works by increasing the osmolality of plasma, which draws water from cells and interstitial spaces into the blood vessels. This osmotic shift expands intravascular volume, promotes renal filtration, and reduces cerebral edema, thereby achieving diuresis and lowering intracranial pressure.

The specific dose of Mannitol Viaflo Baxter is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and therapeutic goals. Dosing regimens are individualized and should follow institutional protocols and the prescriber’s orders.

Mannitol is classified as a Category C medication in many jurisdictions, meaning risk to the fetus cannot be ruled out. It should only be used during pregnancy or lactation if the potential benefit justifies the potential risk, and this decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Mannitol is a non‑metabolizable sugar alcohol that exerts its effect through osmotic mechanisms, similar to agents like hypertonic saline. Compared with hypertonic saline, Mannitol provides a predictable diuretic response and is often preferred for rapid reduction of intracranial pressure, though both require careful monitoring of electrolytes and fluid balance.

Mannitol Viaflo Baxter should be stored at ambient temperature below 25 °C, protected from moisture and direct light. The vial must remain sealed until use, and any reconstituted solution should be used promptly according to the manufacturer’s instructions to maintain sterility.

Mannitol Viaflo Baxter is administered intravenously, typically as a sterile solution injected over several minutes. The infusion rate and total volume are determined by the prescriber, and the drug should be given through a dedicated IV line to avoid incompatibility with other medications.

Serious risks include acute renal failure, pulmonary edema due to fluid overload, severe electrolyte disturbances (especially hyponatremia or hyperkalemia), and rare anaphylactoid reactions. Continuous monitoring of renal function, fluid balance, and serum electrolytes is essential to detect these complications early.

Mannitol is contraindicated in patients with known hypersensitivity to mannitol, severe dehydration, active intracranial bleeding, uncontrolled heart failure, or severe renal impairment where diuresis could worsen kidney function. Clinicians should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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