Product image of Mannitol Vioser (Mannitol) supplied by GNH India

Mannitol Vioser

Active Ingredient:
Mannitol
Origin:
EU

Mannitol Vioser (Mannitol)

Mannitol, the active ingredient in Mannitol Vioser, is an osmotic diuretic presented as a solution for injection for intravenous use. It reduces intracranial and intraocular pressure and promotes diuresis in acute kidney injury.
GNH India supplies Mannitol Vioser as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Vioser S.A.

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Indications & Clinical Uses

Mannitol is an osmotic diuretic used in conditions where fluid shifts reduce pressure or support renal function.

  • Reduction of intracranial pressure: lowers cerebral edema and intracranial pressure.
  • Reduction of intraocular pressure: decreases ocular fluid volume to relieve pressure.
  • Renal protection in acute kidney injury: enhances renal perfusion and promotes urine output.
  • Promotion of diuresis: increases urinary volume in fluid‑overload states.

How It Works

  • Mannitol is a sugar‑alcohol that, when administered intravenously, raises extracellular osmolarity. The resulting osmotic gradient draws water from intracellular and interstitial compartments into the vascular space and renal tubular lumen, inhibiting water reabsorption, producing osmotic diuresis, and reducing cerebral and ocular edema.

Side Effects

Mannitol may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Nausea: feeling of queasiness often with occasional vomiting.
  • Thirst: increased desire for fluids.
  • Electrolyte imbalance (e.g., hyponatremia): mild disturbances in serum electrolytes.

Serious or Rare Side Effects

  • Acute renal failure: sudden loss of kidney function.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.

Precautions & Warnings

Mannitol Vioser requires careful clinical monitoring.

  • Monitor renal function: assess serum creatinine and urine output.
  • Check serum electrolytes: watch for sodium and potassium shifts.
  • Avoid rapid infusion in heart‑failure patients: may worsen fluid overload.
  • Use caution in dehydrated individuals: risk of further volume depletion.
  • Adjust dosing in elderly patients: increased sensitivity to osmotic effects.
  • Store at ambient temperature: keep in original container, protect from moisture and direct light.

Avoid Interactions

Mannitol can interact with several drug classes.

Major Interactions (Avoid)

  • Loop diuretics: may cause excessive diuresis and electrolyte loss.
  • Lithium: increased risk of lithium toxicity.
  • ACE inhibitors: additive renal effects and hypotension.
  • Antihypertensives: may produce synergistic blood‑pressure lowering.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce the diuretic response.
  • Carbamazepine: may increase Mannitol clearance, altering efficacy.
  • Aminoglycosides: heightened risk of nephrotoxicity when combined.

Frequently Asked Questions

Mannitol Vioser is used as an osmotic diuretic to lower intracranial and intraocular pressure, to protect renal function in acute kidney injury, and to promote diuresis in patients with fluid overload. It is administered intravenously in hospital or clinical settings.

Mannitol increases the osmolarity of the extracellular fluid after intravenous infusion. This osmotic gradient pulls water from cells and tissues into the bloodstream and renal tubules, producing diuresis and reducing swelling in the brain and eye.

The dose of Mannitol Vioser is individualized by the prescribing clinician based on the patient’s condition, weight, and response. Specific dosing regimens are not provided here and should follow the prescriber’s orders and institutional protocols.

Safety data for Mannitol Vioser in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Mannitol Vioser, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Mannitol is a widely used osmotic diuretic that provides rapid plasma osmolarity increase, whereas alternatives such as hypertonic saline may have a slower onset and different electrolyte effects. Mannitol’s well‑characterized renal clearance and predictable diuretic response make it a preferred choice in many neurosurgical and renal‑protective protocols.

Mannitol Vioser should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from moisture, direct sunlight, and extreme temperature fluctuations. Do not freeze the product, and inspect the vial for particulate matter before use.

Mannitol Vioser is given by intravenous infusion. The solution is typically diluted with compatible IV fluids and infused over a period determined by the prescriber, often ranging from a few minutes to several hours, depending on the clinical indication and patient tolerance.

Serious risks include acute renal failure, pulmonary edema, severe electrolyte disturbances (such as hyponatremia or hyperkalemia), and rare anaphylactic reactions. Patients should be closely monitored for changes in renal function, fluid balance, and respiratory status during therapy.

Mannitol Vioser is contraindicated in patients with anuria, severe renal impairment, active intracranial hemorrhage, uncontrolled heart failure, or severe dehydration. It should also be avoided in individuals with known hypersensitivity to mannitol or any component of the formulation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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