Product image of Mannitolo Bioindustria L.I.M. (Mannitol) supplied by GNH India

Mannitolo Bioindustria L.I.M.

Active Ingredient:
Mannitol
Origin:
EU

Mannitolo Bioindustria L.I.M. (Mannitol)

Mannitol, the active ingredient in Mannitolo Bioindustria L.I.M., is an osmotic diuretic presented as a sterile intravenous solution for hospital use. It is employed to lower elevated intracranial pressure and to stimulate diuresis in patients with acute renal failure or toxin overload, and to facilitate the renal clearance of certain toxic substances.

GNH India supplies Mannitolo Bioindustria L.I.M. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and intensive‑care units worldwide, with a focus on quality‑assured bulk and unit‑dose deliveries.

Manufacturer / TM Owner

Bioindustria Lim Laboratorio Italiano Medicinali Spa

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Indications & Clinical Uses

  • Mannitol is used as an osmotic agent in several acute medical conditions where rapid fluid shifts are required.
  • Intracranial hypertension: reduces intracranial pressure by drawing water out of brain tissue into the vascular compartment.
  • Acute renal failure: promotes diuresis to enhance urine output and aid renal clearance.
  • Toxin elimination: facilitates renal excretion of nephrotoxic substances by increasing glomerular filtration.

How It Works

  • Mannitol acts as an osmotically active sugar alcohol that, when infused intravenously, raises plasma osmolality. The increased extracellular osmotic pressure pulls water from intracellular spaces into the vascular compartment, expanding intravascular volume and generating an osmotic gradient across the glomerular membrane. This gradient effectively enhances glomerular filtration and urine formation while also decreasing cerebral edema by dehydrating brain cells.

Side Effects

Mannitol may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache
  • Nausea or vomiting
  • Electrolyte imbalance, especially hypernatremia
  • Transient hypotension
  • Mild renal tubular irritation

Serious or Rare Side Effects

  • Acute renal failure
  • Pulmonary edema
  • Severe allergic reactions or anaphylaxis
  • Marked electrolyte disturbances (e.g., severe hyponatremia)
  • Hemolysis in susceptible individuals

Precautions & Warnings

  • When using Mannitol, clinicians should observe several safety measures.
  • Renal function: assess baseline creatinine and monitor urine output.
  • Electrolyte monitoring: check serum sodium, potassium and osmolality regularly.
  • Cardiac status: evaluate for heart failure before administration.
  • Fluid balance: avoid excessive volume overload during infusion.
  • Pregnancy: use only if potential benefit justifies the risk.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Mannitol can interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Loop diuretics: additive diuretic effect may cause severe dehydration.
  • Nephrotoxic antibiotics (e.g., aminoglycosides): increased risk of renal injury.
  • Insulin: may potentiate hypoglycemia due to altered glucose distribution.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: monitor potassium levels and blood pressure.
  • Lithium: risk of toxicity due to altered renal clearance.
  • Antihypertensives: possible additive hypotensive effect.

Frequently Asked Questions

Mannitolo Bioindustria L.I.M. contains mannitol, an osmotic diuretic used primarily to lower elevated intracranial pressure, to promote urine output in acute renal failure, and to aid the renal elimination of certain toxins by increasing glomerular filtration.

Mannitol increases plasma osmolality when given intravenously, creating an osmotic gradient that draws water from intracellular compartments into the bloodstream. This shift expands intravascular volume, enhances kidney filtration, and reduces cerebral edema by dehydrating brain cells.

The dose of Mannitolo Bioindustria L.I.M. is individualized and set by the prescribing clinician based on the patient’s condition, weight, renal function, and therapeutic goals. Specific dosing regimens are not provided here.

Safety data for mannitol in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Use is only recommended when the potential benefit outweighs any possible risk to the mother or infant.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mannitol is a sugar‑alcohol osmotic agent that acts quickly when given intravenously. Compared with hypertonic saline, mannitol provides a larger osmotic gradient without adding sodium load, making it preferred for rapid reduction of intracranial pressure, though both agents have specific clinical niches.

Store Mannitolo Bioindustria L.I.M. at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from direct light and moisture, and avoid freezing to maintain solution stability.

Mannitolo Bioindustria L.I.M. is administered intravenously by a healthcare professional. It is typically given as a sterile solution infused over a controlled period, with dosing and infusion rate determined by the treating physician based on the clinical indication.

Serious risks include acute renal failure, pulmonary edema, severe electrolyte disturbances such as hypernatremia, and rare but life‑threatening allergic reactions or anaphylaxis. Continuous monitoring of renal function, fluid balance and electrolytes is essential during therapy.

Mannitolo Bioindustria L.I.M. should be avoided in patients with known hypersensitivity to mannitol, severe renal impairment, uncontrolled heart failure, active pulmonary edema, or in those where rapid fluid shifts could worsen their condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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