Product image of Manollia (Lisdexamfetamine Dimesylate) supplied by GNH India

Manollia

Active Ingredient:
Lisdexamfetamine Dimesylate
Origin:
EU

Manollia (Lisdexamfetamine Dimesylate)

Lisdexamfetamine dimesylate, the active ingredient in Manollia, is a central nervous system stimulant presented as an oral dosage form for oral use. It is indicated for the treatment of attention deficit hyperactivity disorder and binge eating disorder in children, adolescents, and adults.

GNH India supplies Manollia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

Manollia (lisdexamfetamine) acts on central nervous system pathways that regulate attention, impulse control, and appetite.

  • Attention deficit hyperactivity disorder (ADHD): improves attention, reduces hyperactivity and impulsivity in children, adolescents, and adults.
  • Binge eating disorder: decreases the number of binge‑eating episodes and helps control food intake.

How It Works

  • Lisdexamfetamine dimesylate is a pro‑drug that is enzymatically converted after oral ingestion to the active molecule dextroamphetamine. The released dextroamphetamine stimulates the release of norepinephrine and dopamine and blocks their reuptake in the central nervous system, enhancing neurotransmission in pathways that modulate attention, behavior, and reward.

Side Effects

Like all central nervous system stimulants, lisdexamfetamine may cause a range of adverse reactions.

Common Side Effects

  • Decreased appetite
  • Insomnia
  • Dry mouth
  • Headache

Serious or Rare Side Effects

  • Cardiovascular events such as elevated blood pressure or tachycardia
  • Psychiatric symptoms including new or worsening psychosis or mania
  • Severe allergic reactions, for example anaphylaxis or extensive skin rash

Precautions & Warnings

Before prescribing Manollia, clinicians should evaluate several safety aspects.

  • Cardiovascular assessment: evaluate heart rate and blood pressure before initiating therapy.
  • Psychiatric evaluation: monitor for emergence of anxiety, aggression, or psychotic symptoms.
  • Growth monitoring: track height and weight in pediatric patients regularly.
  • Potential for abuse: prescribe only when benefits outweigh risk of dependence.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Lisdexamfetamine can interact with several medication classes, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): concurrent use can cause hypertensive crisis.
  • Strong CYP2D6 inhibitors: may increase lisdexamfetamine exposure and adverse effects.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: stimulant may reduce their efficacy, requiring blood pressure monitoring.
  • Serotonergic drugs (e.g., SSRIs, SNRIs): may increase risk of serotonin syndrome.
  • Acid‑reducing agents (antacids, H2 blockers): can alter absorption, monitor therapeutic response.

Frequently Asked Questions

Manollia contains lisdexamfetamine dimesylate and is prescribed to manage attention deficit hyperactivity disorder (ADHD) and to reduce binge‑eating episodes in patients with binge eating disorder. It helps improve focus, control impulsivity, and regulate appetite as part of a comprehensive treatment plan.

Lisdexamfetamine is a pro‑drug that is converted in the body to dextroamphetamine. The active molecule increases the release of norepinephrine and dopamine while blocking their reuptake, thereby enhancing neurotransmission in brain circuits that control attention, behavior, and reward processing.

The appropriate dose of Manollia is individualized by a qualified prescriber based on the patient’s age, clinical response, and tolerability. Healthcare professionals determine the starting dose and any subsequent adjustments, following current clinical guidelines and regulatory recommendations.

Safety data for lisdexamfetamine in pregnancy and lactation are limited. Prescribers should weigh potential benefits against possible risks to the fetus or infant and consider alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To request Manollia, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Manollia is a pro‑drug of dextroamphetamine, offering a smoother onset and longer duration compared with immediate‑release stimulants such as mixed amphetamine salts. Unlike methylphenidate, it is metabolized to an active amphetamine, which may provide different efficacy or side‑effect profiles for some patients.

Manollia should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure it is out of reach of children.

Manollia is taken orally, usually once daily in the morning. The tablet should be swallowed whole with water and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks include cardiovascular events such as hypertension or tachycardia, psychiatric effects like new or worsening psychosis or mania, and the potential for dependence or abuse. Patients should seek immediate medical attention if they experience chest pain, severe anxiety, or any signs of an allergic reaction.

Manollia is contraindicated in individuals with known hypersensitivity to lisdexamfetamine or any amphetamine, those who have taken monoamine oxidase inhibitors within the past 14 days, and patients with severe cardiovascular disease, uncontrolled hypertension, or certain psychiatric conditions. A prescriber must evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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