Product image of Maratia (Tramadol Hydrochloride, Paracetamol) supplied by GNH India

Maratia

Active Ingredient:
Tramadol Hydrochloride, Paracetamol
Origin:
EU

Maratia (Tramadol Hydrochloride, Paracetamol)

Tramadol Hydrochloride, the active ingredient in Maratia, is a combination analgesic presented as an oral tablet for oral use. It provides pain relief for moderate to severe acute pain, including postoperative and musculoskeletal pain, by acting on central nervous system pathways.

GNH India supplies Maratia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and regulatory requirements. The company ensures batch traceability and on‑time delivery to meet global healthcare needs.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Maratia, a combination analgesic containing tramadol and paracetamol, is used to manage pain in several clinical situations.

  • Moderate to severe acute pain: provides effective analgesia when non‑opioid agents are insufficient.
  • Postoperative pain: reduces pain intensity after surgical procedures, facilitating recovery.
  • Musculoskeletal pain: alleviates pain associated with injuries or inflammatory conditions of muscles and joints.

How It Works

  • Tramadol Hydrochloride acts as a μ‑opioid receptor agonist and inhibits the reuptake of norepinephrine and serotonin, enhancing descending inhibitory pain pathways. Paracetamol exerts analgesic and antipyretic effects primarily through central cyclooxygenase inhibition, reducing prostaglandin synthesis. The two agents together produce synergistic analgesia by targeting distinct mechanisms within the central nervous system.

Side Effects

Maratia may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset often occurring early in therapy.
  • Dizziness: transient light‑headedness or vertigo.
  • Constipation: reduced bowel movements.
  • Headache: mild to moderate cranial pain.

Serious or Rare Side Effects

  • Respiratory depression: slowed breathing, especially at high doses or with other depressants.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When prescribing Maratia, consider the following precautions.

  • Assess renal and hepatic function: adjust use in patients with impairment.
  • Avoid in patients with known hypersensitivity to tramadol or paracetamol.
  • Use caution with concomitant CNS depressants: increased sedation risk.
  • Monitor for signs of dependence or misuse: especially with prolonged therapy.
  • Pregnancy and breastfeeding: evaluate risk‑benefit before prescribing.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Maratia can interact with several medicines; awareness of the level of interaction helps guide safe use.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.
  • CYP2D6 inhibitors (e.g., quinidine): may increase tramadol plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Serotonergic drugs (SSRIs, SNRIs): potential for serotonin syndrome.
  • Anticoagulants (warfarin): paracetamol may enhance bleeding risk.
  • Anticonvulsants (carbamazepine): may reduce tramadol efficacy.

Frequently Asked Questions

Maratia is indicated for the management of moderate to severe acute pain, including postoperative pain and musculoskeletal pain. It is prescribed when single‑component analgesics are insufficient, providing synergistic relief through its tramadol and paracetamol combination.

Tramadol Hydrochloride binds to μ‑opioid receptors, producing opioid‑like analgesia, and simultaneously inhibits the reuptake of norepinephrine and serotonin, enhancing descending pain‑modulating pathways. This dual action contributes to its effectiveness in acute pain states.

The appropriate dose of Maratia is determined by the prescribing clinician based on the patient’s pain severity, medical history, and concurrent therapies. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidance.

Safety data for Maratia in pregnancy and lactation are limited. Tramadol crosses the placenta and may cause neonatal withdrawal, while paracetamol is generally considered low risk. Clinicians should weigh potential benefits against risks before prescribing to pregnant or nursing women.

To order Maratia, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with single‑agent tramadol, Maratia adds paracetamol, which can enhance analgesia while allowing lower opioid doses. Relative to pure paracetamol, the combination offers stronger relief for moderate‑to‑severe pain but carries additional opioid‑related risks that require careful monitoring.

Maratia should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and heat. Keep the product out of reach of children and avoid exposure to direct sunlight or excessive humidity.

Maratia is taken orally, usually with a full glass of water. It may be taken with or without food, but a consistent approach (with meals or on an empty stomach) can help minimize gastrointestinal discomfort.

The most serious risks include respiratory depression, especially when combined with other central nervous system depressants, and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience difficulty breathing, severe rash, or unexplained swelling.

Maratia is contraindicated in individuals with known hypersensitivity to tramadol, paracetamol, or any component of the formulation, as well as in patients who have taken monoamine‑oxidase inhibitors within the past 14 days. Caution is also advised for those with severe respiratory disorders or uncontrolled epilepsy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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