Product image of Maraviroc supplied by GNH India

Maraviroc

Active Ingredient:
Maraviroc
Origin:
EU

Maraviroc

Maraviroc, the active ingredient in Maraviroc, is a CCR5 antagonist presented as a tablet for oral use. It treats HIV-1 infection in treatment‑experienced patients with CCR5‑tropic virus.

GNH India supplies Maraviroc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Waymade B.V.

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Indications & Clinical Uses

Maraviroc is used in antiretroviral therapy targeting CCR5‑tropic HIV‑1 infection.

  • HIV‑1 infection (treatment‑experienced, CCR5‑tropic virus): provides viral suppression when combined with other antiretrovirals.

How It Works

  • Maraviroc binds to the CCR5 co‑receptor on the surface of CD4+ T cells, blocking the interaction between the receptor and the HIV‑1 envelope glycoprotein gp120. This inhibition prevents the virus from entering and infecting host cells, thereby reducing viral replication and disease progression.

Side Effects

Maraviroc may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Diarrhea: loose stools.
  • Upper respiratory infection: cold‑like symptoms.
  • Fatigue: feeling unusually tired.
  • Rash: skin irritation or redness.

Serious or Rare Side Effects

  • Hepatotoxicity: signs of liver injury.
  • Severe allergic reaction: swelling, breathing difficulty.
  • Depression or mood changes: new or worsening symptoms.
  • Cardiovascular events: chest pain or arrhythmia.
  • Immune reconstitution syndrome: inflammatory response after immune recovery.

Precautions & Warnings

Before prescribing Maraviroc, clinicians should consider several safety measures.

  • Assess CCR5 tropism: confirm virus uses CCR5 before initiation.
  • Monitor liver function: periodic tests recommended.
  • Review concomitant medications: especially CYP3A4 inhibitors or inducers.
  • Educate patients on signs of severe reactions: rash, hepatitis, mood changes.
  • Avoid use in patients with known hypersensitivity to maraviroc.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Maraviroc interacts with several drug classes; careful management is required.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ritonavir, clarithromycin): may increase plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.
  • Antacids containing aluminum or magnesium hydroxide: can lower absorption.

Moderate Interactions (Monitor Closely)

  • Other antiretrovirals (e.g., protease inhibitors): may require dose adjustment.
  • Statins (e.g., simvastatin): increased risk of myopathy.
  • Hormonal contraceptives: possible reduced effectiveness.

Frequently Asked Questions

Maraviroc is an antiretroviral medication indicated for the treatment of HIV‑1 infection in patients who have previously received therapy and whose virus uses the CCR5 co‑receptor. It is used as part of a combination regimen to achieve viral suppression.

Maraviroc blocks the CCR5 co‑receptor on CD4+ T cells, preventing HIV‑1 from binding and entering the cell. By inhibiting this entry step, the drug reduces viral replication and helps control the infection.

The dose of Maraviroc is individualized by the prescribing clinician based on factors such as viral load, treatment history, and concomitant medications. Patients should follow the exact regimen provided by their healthcare professional.

The safety of Maraviroc in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against unknown risks and consider alternative therapies when appropriate.

To request Maraviroc, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Maraviroc belongs to the CCR5 antagonist class, which differs from reverse‑transcriptase inhibitors and protease inhibitors by targeting viral entry rather than replication. It is useful when the virus is CCR5‑tropic and can be combined with other classes for a synergistic effect.

Maraviroc tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged.

Maraviroc is taken orally, usually with food to improve absorption. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include liver toxicity, severe allergic reactions, depression or mood changes, cardiovascular events, and immune reconstitution inflammatory syndrome. Patients should be monitored regularly for these conditions and report any concerning symptoms promptly.

Maraviroc should not be used by individuals with known hypersensitivity to the drug or any of its components, and it is not appropriate for patients whose HIV‑1 strain does not use the CCR5 co‑receptor. Clinicians must verify viral tropism before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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