Product image of Maraviroc Tarbis (Maraviroc) supplied by GNH India

Maraviroc Tarbis

Active Ingredient:
Maraviroc
Origin:
EU

Maraviroc Tarbis (Maraviroc)

Maraviroc, the active ingredient in Maraviroc Tarbis, is a CCR5 antagonist presented as an oral formulation for oral use. It treats HIV‑1 infection in combination with other antiretroviral agents. Maraviroc works by blocking the CCR5 co‑receptor, preventing viral entry into CD4+ cells and reducing viral replication.

GNH India supplies Maraviroc Tarbis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tarbis Farma, S.L.

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Indications & Clinical Uses

Maraviroc is a CCR5 antagonist used in the management of HIV‑1 infection.

  • HIV‑1 infection (treatment‑naïve): reduces viral load when combined with standard antiretroviral regimens.
  • HIV‑1 infection (treatment‑experienced): provides an alternative mechanism for patients with resistance to other agents.
  • HIV‑1 infection (CCR5‑tropic virus): effective when the virus utilizes the CCR5 co‑receptor for cell entry.

How It Works

  • Maraviroc selectively binds to the CCR5 co‑receptor on the surface of CD4+ lymphocytes, blocking the interaction between the receptor and the HIV‑1 envelope glycoprotein gp120. This inhibition prevents the virus from fusing with and entering the host cell, thereby halting replication of CCR5‑tropic HIV strains and contributing to viral load reduction when used with other antiretrovirals.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: may occur with or without vomiting.
  • Diarrhea: usually transient.
  • Fatigue: general tiredness.
  • Cough: dry or productive.
  • Rash: mild skin irritation.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe allergic reaction: anaphylaxis, angioedema.
  • Depression or suicidal thoughts: monitor mental health.
  • QT interval prolongation: risk of cardiac arrhythmia.
  • Stevens‑Johnson syndrome: severe skin reaction.
  • Severe respiratory distress: rare pulmonary complications.

Precautions & Warnings

Before initiating therapy, clinicians should assess patient suitability and monitor for adverse events.

  • Liver function: evaluate baseline enzymes and monitor periodically.
  • Cardiac health: obtain ECG to assess QT interval, especially with other QT‑prolonging drugs.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Pregnancy considerations: use only if potential benefit justifies potential risk.
  • Drug interactions: review concomitant medications for CYP3A4 modulators.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light in the original packaging.

Avoid Interactions

Maraviroc may interact with several co‑administered medicines; careful review is required.

Major Interactions (Avoid)

  • Protease inhibitors (ritonavir, cobicistat): markedly increase maraviroc plasma levels.
  • Strong CYP3A inducers (rifampin, carbamazepine, phenytoin): substantially reduce exposure.
  • QT‑prolonging agents (quinidine, amiodarone): increase risk of cardiac arrhythmia.

Moderate Interactions (Monitor Closely)

  • Other antiretrovirals (efavirenz, nevirapine): may alter maraviroc concentrations.
  • Hepatitis C protease inhibitors (telaprevir, boceprevir): require dose adjustment.
  • Antacids containing aluminum or magnesium: may decrease absorption if taken simultaneously.

Frequently Asked Questions

Maraviroc Tarbis is prescribed as part of combination antiretroviral therapy for the treatment of HIV‑1 infection. It specifically targets viruses that use the CCR5 co‑receptor, helping to lower viral load and improve immune function when used with other approved HIV medicines.

Maraviroc blocks the CCR5 co‑receptor on CD4+ T‑cells, preventing the HIV‑1 envelope protein gp120 from binding. This inhibition stops the virus from entering the cell, thereby reducing replication of CCR5‑tropic HIV strains and contributing to viral suppression in patients receiving combination therapy.

The dosage of Maraviroc Tarbis is individualized by the prescribing clinician based on factors such as viral load, resistance profile, concomitant medications, and patient tolerance. Only a qualified healthcare professional should determine the appropriate dose and schedule.

Safety data for Maraviroc in pregnancy and lactation are limited. It should be used only if the potential maternal benefit outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Unlike nucleoside reverse transcriptase inhibitors or protease inhibitors, Maraviroc targets the CCR5 co‑receptor, offering a distinct mechanism that can be valuable for patients with resistance to other classes. It is used in combination regimens to broaden antiviral activity and may be preferred when the virus is confirmed to be CCR5‑tropic.

Maraviroc Tarbis should be stored at ambient temperature, preferably below 25 °C, in its original container to protect from moisture and light. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity.

Maraviroc is taken orally, usually with food to improve absorption. The tablet should be swallowed whole with a full glass of water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include hepatotoxicity, severe allergic reactions such as anaphylaxis, depression or suicidal ideation, QT interval prolongation leading to cardiac arrhythmias, and rare but severe skin reactions like Stevens‑Johnson syndrome. Patients should report any unusual symptoms promptly to their clinician.

Maraviroc is contraindicated in individuals with known hypersensitivity to maraviroc or any of its excipients. It should also be avoided in patients with severe liver impairment or those taking strong CYP3A inducers that would markedly reduce drug exposure, unless dose adjustments are made under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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