Product image of Marcain Adrenalin (Bupivacaine Hydrochloride, Epinephrine Bitartrate) supplied by GNH India

Marcain Adrenalin

Active Ingredient:
Bupivacaine Hydrochloride, Epinephrine Bitartrate
Origin:
EU

Marcain Adrenalin (Bupivacaine Hydrochloride, Epinephrine Bitartrate)

Bupivacaine hydrochloride, the active ingredient in Marcain Adrenalin, is a local anesthetic presented as an injection solution for infiltration use. It provides long‑lasting numbness for surgical procedures and is combined with epinephrine to limit systemic absorption.
GNH India supplies Marcain Adrenalin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Marcain Adrenalin is a local anesthetic used in procedures that require regional nerve blockade or surface numbness.

  • Local infiltration anesthesia: produces reversible loss of sensation at the injection site for minor surgeries.
  • Peripheral nerve block: delivers targeted anesthesia to a specific nerve or plexus for limb procedures.
  • Epidural anesthesia: provides analgesia for obstetric, orthopedic or abdominal surgeries by blocking spinal nerve transmission.

How It Works

  • Bupivacaine hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of nerve impulses. Epinephrine bitartrate induces vasoconstriction at the injection site, reducing local blood flow and slowing systemic uptake of bupivacaine, thereby prolonging its anesthetic effect and limiting toxicity.

Side Effects

Adverse reactions may occur following administration of Marcain Adrenalin.

Common Side Effects

  • Injection site pain or burning sensation.
  • Transient numbness extending beyond the intended area.
  • Mild hypotension due to epinephrine vasoconstriction.
  • Headache or dizziness.
  • Nausea or mild vomiting.

Serious or Rare Side Effects

  • Cardiovascular toxicity such as arrhythmias or cardiac arrest.
  • Central nervous system toxicity including seizures or respiratory depression.
  • Severe allergic reaction (anaphylaxis).
  • Persistent motor block.
  • Methemoglobinemia (rare).

Precautions & Warnings

When using Marcain Adrenalin, clinicians should consider several safety measures.

  • Patient assessment: evaluate cardiac history and potential hypersensitivity before injection.
  • Dose limitation: adhere to recommended maximum dose to avoid systemic toxicity.
  • Monitoring: observe vital signs and neurological status during and after administration.
  • Drug interactions: avoid concurrent use with other local anesthetics or vasoconstrictors unless clinically justified.
  • Special populations: use with caution in elderly or patients with hepatic impairment.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Marcain Adrenalin may interact with other medications that affect cardiovascular or nervous system function.

Major Interactions (Avoid)

  • Other local anesthetics: additive toxicity risk.
  • Class I antiarrhythmic agents: increased risk of cardiac conduction disturbances.
  • Monoamine oxidase inhibitors (MAOIs): potential for severe hypertension.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may mask tachycardia signs of toxicity.
  • Calcium channel blockers: can enhance negative inotropic effects.
  • Diuretics: may alter plasma protein binding and affect drug levels.

Frequently Asked Questions

Marcain Adrenalin is used to provide local or regional anesthesia for surgical procedures. It is indicated for infiltration anesthesia, peripheral nerve blocks, and epidural anesthesia, allowing clinicians to achieve targeted numbness while minimizing systemic exposure.

Bupivacaine blocks voltage‑gated sodium channels on nerve membranes, stopping the propagation of action potentials. The added epinephrine causes local vasoconstriction, which reduces blood flow at the injection site, prolonging the anesthetic effect and limiting systemic absorption.

The dose of Marcain Adrenalin is determined by the prescribing clinician based on the specific procedure, patient characteristics, and the anatomical site. Healthcare professionals calculate the appropriate volume and concentration to stay within safe limits.

Safety data for Marcain Adrenalin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order Marcain Adrenalin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Compared with shorter‑acting agents such as lidocaine, bupivacaine in Marcain Adrenalin offers a longer duration of anesthesia, which can be advantageous for prolonged procedures. The addition of epinephrine further extends its effect and reduces systemic absorption, distinguishing it from plain bupivacaine formulations.

Marcain Adrenalin should be stored below 25 °C in its original packaging. Protect the solution from light, moisture and extreme temperature fluctuations to maintain potency and sterility.

Marcain Adrenalin is administered by a qualified healthcare professional as an injection solution. It is injected directly into the tissue, nerve sheath, or epidural space, depending on the intended anesthetic technique.

The most serious risks include cardiovascular toxicity such as arrhythmias or cardiac arrest, and central nervous system toxicity leading to seizures or respiratory depression. Prompt recognition and supportive management are essential if these events occur.

Patients with known hypersensitivity to bupivacaine, epinephrine, or any component of the formulation should not receive Marcain Adrenalin. Caution is also advised in individuals with severe cardiac disease, uncontrolled hypertension, or significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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