Product image of Marcain-Adrenalin (Bupivacaine Hydrochloride, Epinephrine) supplied by GNH India

Marcain-Adrenalin

Active Ingredient:
Bupivacaine Hydrochloride, Epinephrine
Origin:
EU

Marcain-Adrenalin (Bupivacaine Hydrochloride, Epinephrine)

Bupivacaine Hydrochloride, the active ingredient in Marcain-Adrenalin, is a local anesthetic with vasoconstrictor presented as a sterile solution for epidural, infiltration, and intra‑articular use. It provides prolonged sensory block for surgical and procedural pain control in adult patients.

GNH India supplies Marcain-Adrenalin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable cold‑chain logistics where required. The company adheres to stringent GMP standards and provides comprehensive documentation for import and distribution across EU and global markets.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Marcain-Adrenalin, a local anesthetic with vasoconstrictor, is employed in clinical settings that require regional or local nerve block.

  • Surgical anesthesia: provides profound sensory blockade during operative procedures, reducing intra‑operative pain.
  • Procedural analgesia: offers targeted pain relief for minor surgeries and diagnostic interventions.
  • Pain management: used for postoperative or chronic pain control when a prolonged local effect is desired.

How It Works

  • Bupivacaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarisation and impulse transmission. Epinephrine activates α‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that reduces systemic absorption of bupivacaine, thereby extending its duration of action and limiting peak plasma concentrations. The combined effect yields a rapid onset of anesthesia with a prolonged duration, allowing clinicians to perform longer procedures with reduced need for repeat dosing.

Side Effects

Adverse reactions to Marcain-Adrenalin may vary in frequency and severity.

Common Side Effects

  • Transient pain at injection site: mild discomfort that resolves within hours.
  • Tingling or numbness: temporary sensory changes in the anesthetized area.
  • Hypotension: mild drop in blood pressure due to vasodilatory response.
  • Bradycardia: slowed heart rate occasionally observed.

Serious or Rare Side Effects

  • Cardiovascular toxicity: arrhythmias, cardiac arrest in cases of high systemic absorption.
  • Central nervous system toxicity: seizures, loss of consciousness.
  • Allergic reaction: urticaria, bronchospasm, anaphylaxis.
  • Persistent paresthesia: prolonged nerve injury causing lasting sensory deficits.

Precautions & Warnings

When using Marcain-Adrenalin, clinicians should observe specific safety measures to minimise risk.

  • Patient assessment: evaluate cardiovascular status and allergy history before administration.
  • Dose calculation: base total dose on patient weight and maximum recommended limits.
  • Monitoring: observe vital signs and neurologic status during and after injection.
  • Contraindications: avoid use in patients with known hypersensitivity to bupivacaine or epinephrine.
  • Drug interactions: consider additive effects with other local anesthetics or vasoconstrictors.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Marcain-Adrenalin can interact with several medications; awareness of these interactions helps prevent adverse events.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may increase risk of cardiac toxicity.
  • Beta‑blockers: can potentiate bradycardia and hypotension when combined with epinephrine.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative toxicity risk; adjust total dose accordingly.
  • Monoamine oxidase inhibitors (MAOIs): may enhance epinephrine‑related cardiovascular effects.
  • Diuretics: can alter plasma concentration of bupivacaine, requiring closer monitoring.

Frequently Asked Questions

Marcain-Adrenalin is a combination of bupivacaine hydrochloride and epinephrine used to provide local or regional anesthesia for surgical procedures, procedural analgesia, and postoperative or chronic pain management where a prolonged anesthetic effect is required.

Bupivacaine blocks voltage‑gated sodium channels on nerve membranes, preventing the initiation and propagation of action potentials. This inhibition stops pain signal transmission, resulting in loss of sensation in the targeted area.

The dose is determined by the prescribing clinician based on the patient’s age, weight, the specific procedure, and the maximum allowable dose for bupivacaine. Exact dosing regimens are individualized and should follow the prescriber’s instructions.

Safety data for bupivacaine with epinephrine in pregnancy and lactation are limited. Use is only recommended if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Marcain-Adrenalin adds epinephrine to bupivacaine, which causes local vasoconstriction. This reduces systemic absorption, prolongs the duration of anesthesia, and can lower the required total dose compared with plain bupivacaine, while also providing better haemostatic control at the injection site.

The product should be stored below 25 °C in its original container, protected from light and moisture. Do not freeze. Follow any additional instructions on the label regarding temperature excursions.

Marcain-Adrenalin is supplied as a sterile injectable solution and is administered by a qualified healthcare professional via epidural, infiltration, or intra‑articular injection, depending on the intended clinical use and anatomical site.

Serious risks include cardiovascular toxicity such as arrhythmias or cardiac arrest, central nervous system toxicity including seizures, and rare but severe allergic reactions like anaphylaxis. Prompt recognition and supportive management are essential.

Patients with known hypersensitivity to bupivacaine, epinephrine, or any component of the formulation should not receive the product. It is also contraindicated in individuals with certain cardiac conditions where vasoconstriction could be harmful, unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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