Product image of Marcain Spinal Tung (Bupivacaine Hydrochloride) supplied by GNH India

Marcain Spinal Tung

Active Ingredient:
Bupivacaine Hydrochloride
Origin:
EU

Marcain Spinal Tung (Bupivacaine Hydrochloride)

Bupivacaine hydrochloride, the active ingredient in Marcain Spinal Tung, is a local anesthetic presented as a sterile solution for epidural and intrathecal use. It provides surgical anesthesia and analgesia for patients undergoing operative procedures, including obstetric, orthopedic, and general surgery.

GNH India supplies Marcain Spinal Tung as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to European Union quality standards and ensures consistent product availability across global markets.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Bupivacaine hydrochloride is a local anesthetic used in spinal and epidural pathways to achieve regional anesthesia.

  • Surgical anesthesia: provides profound loss of sensation for operative procedures.
  • Epidural analgesia: delivers continuous pain relief during labor or postoperative recovery.
  • Spinal anesthesia: induces rapid, dense sensory block for lower‑body surgeries.

How It Works

  • Bupivacaine hydrochloride reversibly binds to voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel. This inhibition prevents sodium influx required for depolarization, thereby blocking initiation and propagation of nerve impulses. The result is a reversible loss of sensory and motor function in the targeted region, allowing controlled anesthesia during surgical or obstetric procedures.

Side Effects

Bupivacaine may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hypotension: transient drop in blood pressure after injection.
  • Bradycardia: slowed heart rate.
  • Nausea: feeling of sickness.
  • Pruritus: localized itching at the injection site.
  • Headache: mild to moderate tension‑type headache.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythm that can be life‑threatening.
  • Seizures: central nervous system excitation leading to convulsions.
  • Respiratory depression: reduced breathing effort.
  • Methemoglobinemia: abnormal hemoglobin affecting oxygen transport.

Precautions & Warnings

When using Marcain Spinal Tung, clinicians should observe several precautionary measures to minimize risk.

  • Patient assessment: evaluate cardiovascular and neurological status before administration.
  • Dose calculation: base dose on patient weight, age, and clinical setting.
  • Monitoring: continuously observe blood pressure, heart rate, and oxygen saturation during and after injection.
  • Allergic history: confirm no known hypersensitivity to amide‑type local anesthetics.
  • Drug interactions: avoid concurrent use with agents that may potentiate CNS or cardiac toxicity.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Bupivacaine can interact with other medications, influencing its safety profile.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine, procainamide): may enhance cardiotoxicity.
  • CNS depressants (e.g., benzodiazepines, barbiturates): increase risk of respiratory depression.
  • Lithium: potentiates neurotoxic effects.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may exacerbate bradycardia.
  • Calcium channel blockers: can augment hypotensive response.
  • MAO inhibitors: may alter plasma concentrations.
  • Epinephrine (when added): can increase systemic absorption and toxicity.

Frequently Asked Questions

Marcain Spinal Tung is used to provide regional anesthesia and analgesia via epidural or intrathecal injection. It is employed for surgical anesthesia, epidural pain relief during labor, and spinal anesthesia for lower‑body surgeries, allowing controlled loss of sensation and muscle relaxation in the targeted area.

Bupivacaine hydrochloride blocks voltage‑gated sodium channels on nerve membranes, stabilizing them in an inactive state. By preventing sodium influx, it stops the generation and propagation of nerve impulses, resulting in a reversible loss of sensory and motor function in the region where it is administered.

The dose of Marcain Spinal Tung is determined by the prescribing clinician based on the patient’s weight, age, type of procedure, and clinical setting. Only a qualified healthcare professional should calculate and administer the appropriate amount.

Safety data for bupivacaine during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating obstetrician or anesthesiologist.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Bupivacaine, the active ingredient in Marcain Spinal Tung, has a longer duration of action than agents such as lidocaine or mepivacaine, making it suitable for prolonged procedures. However, its higher potency also requires careful monitoring for cardiotoxicity, especially at higher doses.

Store the product below 25 °C in its original packaging, protecting it from light and moisture. Avoid freezing and keep the vial sealed until use. Follow standard aseptic techniques when preparing the solution for epidural or intrathecal injection.

Marcain Spinal Tung is administered by a trained anesthesiologist or qualified clinician via epidural or intrathecal injection. The sterile solution is injected into the epidural space or subarachnoid space using appropriate needles or catheters, with dosage adjusted to the individual patient and procedure.

Serious risks include cardiac arrhythmias, severe hypotension, respiratory depression, seizures, and rare cases of methemoglobinemia. Immediate monitoring of cardiovascular and respiratory parameters is essential, and emergency resuscitation equipment should be readily available.

Patients with known hypersensitivity to bupivacaine or other amide‑type local anesthetics, those with severe cardiac conduction disorders, uncontrolled epilepsy, or significant hepatic impairment should avoid using Marcain Spinal Tung unless a risk‑benefit assessment justifies its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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