Product image of Marcaine 0,5 % Adrenaline (Epinephrine, Bupivacaine Hydrochloride, Anhydrous) supplied by GNH India

Marcaine 0,5 % Adrenaline

Active Ingredient:
Epinephrine, Bupivacaine Hydrochloride, Anhydrous
Origin:
EU

Marcaine 0,5 % Adrenaline (Epinephrine, Bupivacaine Hydrochloride, Anhydrous)

Bupivacaine hydrochloride, the active ingredient in Marcaine 0,5 % Adrenaline, is a local anesthetic presented as a 0.5 % injection solution for epidural and infiltration use. It provides regional or local anesthesia for surgical procedures, labor analgesia, and other invasive interventions in adult patients.

GNH India supplies Marcaine 0,5 % Adrenaline as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability and regulatory support across multiple regions.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Marcaine 0,5 % Adrenaline, a combination local anesthetic and vasoconstrictor, is employed in procedures requiring regional or infiltration anesthesia.

  • Surgical procedures: provides localized numbness to facilitate incision, tissue dissection and postoperative pain control.
  • Labor and delivery: delivers epidural analgesia to reduce pain during childbirth while maintaining maternal consciousness.
  • Minor invasive interventions: enables infiltration anesthesia for dental work, skin suturing and small orthopedic procedures.

How It Works

  • Marcaine 0,5 % Adrenaline contains bupivacaine hydrochloride, which blocks voltage‑gated sodium channels on neuronal membranes, preventing initiation and propagation of nerve impulses. The added epinephrine acts on α‑adrenergic receptors causing local vasoconstriction, which limits systemic absorption of bupivacaine, prolongs its anesthetic effect, and reduces bleeding at the injection site. These actions together produce a rapid onset of profound sensory blockade with a duration that can exceed several hours.

Side Effects

Adverse reactions to Marcaine 0,5 % Adrenaline are generally related to the local anesthetic component or the epinephrine vasoconstrictor.

Common Side Effects

  • Transient hypotension: mild drop in blood pressure shortly after injection.
  • Injection site pain: localized discomfort at the administration site.
  • Metallic taste: brief taste disturbance after infiltration.

Serious or Rare Side Effects

  • Cardiac arrhythmias: irregular heart rhythm that may be life‑threatening.
  • Severe hypotension: marked blood pressure fall requiring intervention.
  • Allergic reactions: rash, itching, bronchospasm or anaphylaxis.

Precautions & Warnings

When using Marcaine 0,5 % Adrenaline, clinicians should observe several safety measures to minimize risks.

  • Cardiac history: avoid or use with caution in patients with significant conduction disorders or recent myocardial infarction.
  • Beta‑blocker therapy: monitor for exaggerated hypertensive response due to epinephrine.
  • Dose limits: adhere to recommended maximum bupivacaine dose to prevent systemic toxicity.
  • Pregnancy: consider risk‑benefit; category B indicates no proven fetal harm but use only if clearly needed.
  • Pediatric use: adjust dose carefully based on weight and monitor for signs of toxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Marcaine 0,5 % Adrenaline may interact with other medicines, altering its safety or effectiveness.

Major Interactions (Avoid)

  • MAO inhibitors: concurrent use can precipitate severe hypertension from epinephrine.
  • Non‑selective β‑blockers: may enhance epinephrine‑induced vasoconstriction and raise blood pressure.
  • Other local anesthetics: additive toxicity risk, especially with bupivacaine.

Moderate Interactions (Monitor Closely)

  • CNS depressants: may potentiate central nervous system effects of bupivacaine.
  • Diuretics: may alter plasma levels of bupivacaine, requiring dose adjustment.

Frequently Asked Questions

Marcaine 0,5 % Adrenaline is a combination of bupivacaine and epinephrine used to provide local or regional anesthesia. It is indicated for surgical procedures, epidural analgesia during labor, and infiltration anesthesia for minor invasive interventions.

Bupivacaine hydrochloride blocks voltage‑gated sodium channels on nerve membranes, preventing the initiation and propagation of action potentials. This interruption of nerve signaling produces loss of sensation in the targeted area, resulting in anesthesia.

The dose is individualized by the prescribing clinician based on the type of procedure, patient weight, age, and overall health. Only a qualified health professional should set the dosage and administration schedule.

Marcaine is classified as pregnancy category B, indicating no evidence of fetal risk in animal studies and a lack of well‑controlled human data. It may be used during pregnancy or lactation only when the potential benefit justifies any potential risk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Marcaine (bupivacaine) has a longer duration of action and a higher potency than lidocaine, making it suitable for procedures requiring prolonged anesthesia. However, its onset is slower, and the risk of cardiotoxicity at high doses is greater, so careful dosing is essential.

Marcaine 0,5 % Adrenaline should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the product in its original packaging until use to maintain sterility and potency.

Marcaine is supplied as a sterile injection solution and is administered by a qualified health professional via epidural catheter, nerve block, or direct infiltration into the target tissue. The route and technique depend on the clinical indication and procedural requirements.

Serious risks include cardiac arrhythmias, severe hypotension, allergic reactions such as anaphylaxis, and central nervous system toxicity leading to seizures. Prompt recognition and management of these events are critical to patient safety.

Patients with known hypersensitivity to bupivacaine, epinephrine, or any formulation components should avoid the product. It is also contraindicated in individuals with significant cardiac conduction disorders, uncontrolled hypertension, or those taking MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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