Product image of Marcaine Adrenaline (Bupivacaine Hydrochloride, Epinephrine Bitartrate) supplied by GNH India

Marcaine Adrenaline

Active Ingredient:
Bupivacaine Hydrochloride, Epinephrine Bitartrate
Origin:
EU

Marcaine Adrenaline (Bupivacaine Hydrochloride, Epinephrine Bitartrate)

Bupivacaine Hydrochloride, the active ingredient in Marcaine Adrenaline, is a local anesthetic presented as a sterile solution for epidural and infiltration use. It provides prolonged analgesia by blocking nerve impulse transmission and is commonly employed in surgical and obstetric procedures.

GNH India supplies Marcaine Adrenaline as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Marcaine Adrenaline is a local anesthetic used in procedures that require regional or infiltration analgesia.

  • Surgical anesthesia: produces deep, long‑lasting numbness for operative sites.
  • Epidural analgesia: provides continuous pain relief during labor or postoperative recovery.
  • Infiltration anesthesia: numbs localized tissue for minor surgeries or dental work.

How It Works

  • Bupivacaine Hydrochloride reversibly inhibits neuronal voltage‑gated sodium channels, preventing depolarization and nerve impulse conduction. Epinephrine Bitartrate causes local vasoconstriction through alpha‑adrenergic receptor activation, reducing systemic absorption of bupivacaine and extending its anesthetic duration.

Side Effects

Marcaine Adrenaline may cause a range of adverse reactions, most of which are dose‑dependent and related to its local anesthetic and vasoconstrictive properties.

Common Side Effects

  • Injection site pain or burning sensation
  • Transient hypotension or dizziness
  • Nausea or vomiting
  • Metallic taste in the mouth
  • Mild headache
  • Temporary visual disturbances

Serious or Rare Side Effects

  • Cardiovascular collapse or severe arrhythmia
  • Prolonged or total spinal block
  • Allergic reaction including anaphylaxis
  • Seizures or central nervous system toxicity
  • Respiratory depression or apnea
  • Methemoglobinemia (rare)

Precautions & Warnings

When using Marcaine Adrenaline, clinicians should observe several safety measures to minimize risk.

  • Allergy assessment: confirm no hypersensitivity to bupivacaine or epinephrine.
  • Cardiovascular caution: avoid high concentrations in patients with severe heart disease.
  • Hepatic impairment: consider reduced clearance in severe liver dysfunction.
  • Obstetric use: monitor fetal heart rate when administered epidurally during labor.
  • Elderly patients: use the lowest effective dose and monitor for prolonged block.
  • Store at ambient temperature: keep in original container, protect from moisture and direct light.

Avoid Interactions

Marcaine Adrenaline can interact with several drug classes, altering its safety profile or efficacy.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): increase risk of hypertensive crisis.
  • Beta‑blockers: may blunt epinephrine‑induced tachycardia, leading to unopposed vasoconstriction.
  • Other local anesthetics: additive neurotoxicity.
  • Sympathomimetic agents: excessive vasoconstriction.
  • QT‑prolonging drugs: heightened risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: increased bleeding risk at injection site.
  • CYP450 inhibitors (e.g., ketoconazole): may slow bupivacaine metabolism.
  • Drugs affecting hepatic blood flow (e.g., propofol): alter clearance.
  • Diuretics: potential electrolyte shifts influencing cardiac response.
  • ACE inhibitors: may enhance hypotensive effects.

Frequently Asked Questions

Marcaine Adrenaline is a combination of bupivacaine and epinephrine used to provide regional or infiltration anesthesia. It is commonly employed for surgical anesthesia, epidural analgesia during labor or postoperative care, and local infiltration to numb tissue for minor procedures.

Bupivacaine blocks voltage‑gated sodium channels on nerve membranes, preventing depolarization and halting the transmission of pain signals. The added epinephrine causes local blood‑vessel constriction, which slows systemic absorption of bupivacaine, extending its duration of action.

The specific dose of Marcaine Adrenaline is determined by the prescribing clinician based on the type of procedure, patient age, weight, and clinical condition. Healthcare professionals calculate the appropriate volume and concentration to achieve the desired anesthetic effect.

Safety data for Marcaine Adrenaline in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Clinicians weigh potential benefits against risks and may limit use to situations where effective anesthesia is essential.

To request Marcaine Adrenaline, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Marcaine Adrenaline combines bupivacaine with epinephrine, whereas plain bupivacaine lacks the vasoconstrictor. The epinephrine component reduces systemic absorption, prolongs the anesthetic effect, and can lower bleeding at the injection site, making Marcaine Adrenaline preferable for procedures requiring extended analgesia.

Marcaine Adrenaline should be stored at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly sealed to maintain sterility.

Marcaine Adrenaline is administered by a qualified healthcare professional via epidural injection, peripheral nerve block, or direct infiltration into the target tissue. The solution is injected using sterile technique, and the volume is adjusted according to the specific clinical indication.

Serious risks include cardiovascular collapse, severe arrhythmias, prolonged spinal or epidural block, allergic reactions such as anaphylaxis, central nervous system toxicity leading to seizures, and respiratory depression. Immediate medical attention is required if any of these events occur.

Marcaine Adrenaline is contraindicated in patients with known hypersensitivity to bupivacaine, epinephrine, or any formulation components. It should also be avoided in individuals with severe cardiac disease, uncontrolled hypertension, or certain metabolic disorders where vasoconstriction could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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