Product image of Marcaine Adrenaline (Epinephrine, Bupivacaine Hydrochloride, Anhydrous) supplied by GNH India

Marcaine Adrenaline

Active Ingredient:
Epinephrine, Bupivacaine Hydrochloride, Anhydrous
Origin:
EU

Marcaine Adrenaline (Epinephrine, Bupivacaine Hydrochloride, Anhydrous)

Bupivacaine hydrochloride and epinephrine, the active ingredients in Marcaine Adrenaline, are a local anesthetic (amide) combined with a vasoconstrictor presented as an injection solution for epidural and infiltration use. They provide regional numbness and prolonged pain relief for patients undergoing surgical procedures or requiring targeted analgesia.

GNH India supplies Marcaine Adrenaline as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and offers reliable global distribution. Customers benefit from comprehensive technical support and regulatory assistance.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

  • Marcaine Adrenaline, a combination local anesthetic and vasoconstrictor, is employed in clinical settings that require regional nerve block or targeted pain control.
  • Surgical anesthesia: provides profound sensory block for operative procedures, facilitating a bloodless field and patient comfort.
  • Epidural analgesia: delivers continuous pain relief during labor, postoperative recovery, or chronic pain management.
  • Infiltration anesthesia: creates localized numbness for minor surgical, dental, or diagnostic interventions.

How It Works

  • Bupivacaine binds to voltage‑gated sodium channels on neuronal membranes, stabilising the inactive state and preventing depolarisation, which blocks nerve impulse transmission. Epinephrine stimulates alpha‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that limits systemic absorption of bupivacaine, thereby extending its local anesthetic duration and reducing peak plasma concentrations.

Side Effects

Marcaine Adrenaline may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Injection site pain or burning sensation.
  • Transient hypotension or mild bradycardia.
  • Nausea or dizziness.
  • Metallic taste or mild headache.

Serious or Rare Side Effects

  • Cardiovascular collapse or severe arrhythmias.
  • Prolonged motor block or spinal cord toxicity.
  • Allergic reactions including anaphylaxis.
  • Seizures, respiratory depression, or cardiac arrest.

Precautions & Warnings

  • When using Marcaine Adrenaline, clinicians should observe several precautionary measures to minimize risk.
  • Pregnancy: Category C – administer only when benefit justifies potential risk to the fetus.
  • Cardiovascular disease: monitor heart rate and blood pressure for arrhythmias or hypertension.
  • Epinephrine contraindication: avoid in patients with uncontrolled hypertension or hyperthyroidism.
  • Intravascular injection: aspirate before administration to prevent systemic toxicity.
  • Hypersensitivity: do not use in individuals with known allergy to amide local anesthetics.
  • Store at controlled room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Marcaine Adrenaline can interact with other medications, influencing its safety and efficacy.

Major Interactions (Avoid)

  • Beta‑blockers: may potentiate epinephrine‑induced hypertension.
  • MAO inhibitors: increased risk of hypertensive crisis with epinephrine.
  • Tricyclic antidepressants: may enhance bupivacaine cardiotoxicity.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may affect cardiac conduction when combined with epinephrine.
  • Other sodium‑channel blockers: increase risk of systemic local anesthetic toxicity.
  • General anesthetics: additive central nervous system depression may occur.

Frequently Asked Questions

Marcaine Adrenaline is a combination of bupivacaine and epinephrine used to provide regional anesthesia and analgesia. It is indicated for surgical anesthesia, epidural analgesia during labor or postoperative care, and infiltration anesthesia for minor procedures requiring localized numbness.

Bupivacaine blocks voltage‑gated sodium channels on nerve membranes, preventing depolarisation and halting transmission of pain signals. This produces a long‑lasting sensory block in the area where the drug is administered.

The specific dose of Marcaine Adrenaline is determined by the prescribing clinician based on the type of procedure, patient characteristics, and desired duration of anesthesia. Dosage is individualized and should follow local clinical guidelines.

Marcaine Adrenaline is classified as Pregnancy Category C, meaning it should be used only if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding; the decision should be made by the healthcare provider after evaluating risks and benefits.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Marcaine Adrenaline combines bupivacaine with epinephrine, which causes local vasoconstriction. This prolongs the anesthetic effect, reduces systemic absorption, and can provide a clearer surgical field compared with bupivacaine alone, which lacks the vasoconstrictive component.

Marcaine Adrenaline should be stored at controlled room temperature, typically below 25 °C. Keep the vial in its original packaging, protect it from light and moisture, and avoid freezing or shaking the solution.

The product is supplied as an injectable solution and is administered by a qualified healthcare professional via epidural catheter, nerve block, or direct infiltration into the target tissue. Proper aseptic technique and aspiration before injection are essential to avoid intravascular administration.

Serious risks include cardiovascular collapse, severe arrhythmias, prolonged motor block, allergic reactions such as anaphylaxis, seizures, and, in rare cases, cardiac arrest. Immediate monitoring and emergency preparedness are required when the drug is used.

Patients with known hypersensitivity to amide‑type local anesthetics, uncontrolled hypertension, hyperthyroidism, or certain cardiac conditions should not receive Marcaine Adrenaline. It is also contraindicated in individuals where epinephrine is prohibited, such as those on non‑selective beta‑blockers without careful monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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