Product image of Marcaine Adrenaline (Epinephrine, Bupivacaine Hydrochloride, Anhydrous) supplied by GNH India

Marcaine Adrenaline

Active Ingredient:
Epinephrine, Bupivacaine Hydrochloride, Anhydrous
Origin:
EU

Marcaine Adrenaline (Epinephrine, Bupivacaine Hydrochloride, Anhydrous)

Bupivacaine hydrochloride and epinephrine, the active ingredient in Marcaine Adrenaline, is an amide-type local anesthetic presented as a solution for injection for epidural, infiltration, intraarticular use. It provides local anesthesia for surgical procedures and related interventions.

GNH India supplies Marcaine Adrenaline as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

  • Marcaine Adrenaline, an amide‑type local anesthetic with vasoconstrictor, is used for procedures requiring regional or local anesthesia.
  • Surgical procedures: provides reliable numbness for incisions and operative sites.
  • Epidural anesthesia: delivers prolonged analgesia during labor or abdominal surgery.
  • Infiltration anesthesia: numbs tissue for minor surgeries, dental work or wound repair.
  • Intraarticular anesthesia: facilitates joint procedures such as arthroscopy and ligament repair.

How It Works

  • Bupivacaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarisation and nerve impulse propagation. Epinephrine activates α‑adrenergic receptors on local blood vessels, causing vasoconstriction that limits systemic absorption of bupivacaine, prolongs its anesthetic effect, and reduces peak plasma concentrations.

Side Effects

Marcaine Adrenaline may cause a range of adverse reactions.

Common Side Effects

  • Transient pain or burning at the injection site.
  • Tingling, numbness or mild paraesthesia in the treated area.
  • Mild hypotension due to vasodilatory reflexes.
  • Bradycardia, especially when epinephrine is used in high concentrations.

Serious or Rare Side Effects

  • Cardiac arrhythmias, including ventricular tachycardia.
  • Severe hypotension or hypertensive crisis.
  • Allergic reactions ranging from urticaria to anaphylaxis.
  • Neurotoxicity such as seizures or central nervous system depression.

Precautions & Warnings

  • When using Marcaine Adrenaline, clinicians should observe several safety measures.
  • Patient assessment: evaluate cardiac history, allergy status and concomitant medications.
  • Dose limitation: avoid exceeding recommended volume for the specific block technique.
  • Concurrent vasoconstrictors: monitor for excessive vasoconstriction and tissue ischemia.
  • Epinephrine sensitivity: avoid in patients with uncontrolled hypertension or known catecholamine‑sensitive conditions.
  • Pregnancy: use only if the anticipated benefit justifies potential risk to the fetus.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Marcaine Adrenaline can interact with other drugs that affect cardiovascular or nervous system function.

Major Interactions (Avoid)

  • Beta‑blockers: may potentiate epinephrine‑induced hypertension and bradycardia.
  • Monoamine oxidase inhibitors (MAOIs): increase risk of hypertensive crisis with epinephrine.
  • Tricyclic antidepressants: may enhance arrhythmogenic potential when combined with epinephrine.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics (e.g., lidocaine): additive risk of systemic toxicity.
  • Calcium channel blockers: may affect cardiac conduction when combined with epinephrine.
  • Diuretics: can alter plasma concentration of bupivacaine, requiring careful monitoring.

Frequently Asked Questions

Marcaine Adrenaline is a combination of bupivacaine hydrochloride and epinephrine used to provide local or regional anesthesia for surgical procedures, epidural analgesia, infiltration of tissues, and intra‑articular injections during joint surgeries.

Bupivacaine blocks voltage‑gated sodium channels on nerves, stopping impulse transmission. Epinephrine causes vasoconstriction by stimulating α‑adrenergic receptors, which reduces blood flow at the injection site, prolonging the anesthetic effect and limiting systemic absorption.

The specific dose and volume are determined by the prescribing clinician based on the type of procedure, patient characteristics, and the anatomical site. Dosing guidelines are provided in the product’s prescribing information and must be followed by qualified healthcare professionals.

Safety in pregnancy and lactation has not been definitively established. Use is reserved for situations where the expected benefit outweighs potential risks, and the decision should be made by the treating physician in consultation with the patient.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

The addition of epinephrine to bupivacaine creates a vasoconstrictive effect that prolongs the duration of anesthesia and reduces systemic absorption, offering longer pain control compared with bupivacaine alone, especially in highly vascular tissues.

Store at ambient temperature, preferably below 25 °C, in the original sealed container. Protect from direct light, moisture and extreme temperatures. Do not freeze the solution and ensure the vial is kept upright to avoid agitation.

Marcaine Adrenaline is supplied as a sterile solution for injection and is administered by a qualified healthcare professional via epidural, infiltration or intra‑articular routes, using aseptic technique and appropriate needle or catheter sizes for the intended block.

Serious risks include cardiac arrhythmias, severe hypotension or hypertension, allergic reactions such as anaphylaxis, and neurotoxicity leading to seizures. Prompt recognition and management of these events are essential.

Patients with known hypersensitivity to bupivacaine, epinephrine, or any component of the formulation, those with uncontrolled hypertension, certain cardiac conduction disorders, or severe peripheral vascular disease should avoid this medication unless benefits clearly outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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