Product image of Marcaine Spinal 0,5% Heavy (Bupivacaine Hydrochloride) supplied by GNH India

Marcaine Spinal 0,5% Heavy

Active Ingredient:
Bupivacaine Hydrochloride
Origin:
EU

Marcaine Spinal 0,5% Heavy (Bupivacaine Hydrochloride)

Bupivacaine Hydrochloride, the active ingredient in Marcaine Spinal 0,5% Heavy, is a local anesthetic presented as a 0.5% (5 mg/mL) injectable solution for intrathecal use. It provides surgical and spinal anesthesia and pain management during operative procedures.

GNH India supplies Marcaine Spinal 0,5% Heavy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide, ensuring EU‑standard quality and global logistics support.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Marcaine Spinal 0,5% Heavy (bupivacaine hydrochloride) is used for spinal anesthesia in surgical settings.

  • Surgical anesthesia: provides dense sensory and motor block for procedures requiring complete anesthesia.
  • Spinal anesthesia: enables regional block for lower abdominal, pelvic, or lower‑limb surgeries.
  • Pain management during surgery: offers prolonged analgesia throughout the operative period.
  • Obstetric procedures: facilitates anesthesia for cesarean sections when a spinal technique is chosen.

How It Works

  • Bupivacaine hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarization and propagation of nerve impulses. This inhibition stops the transmission of pain signals and produces a reversible loss of sensation and motor function in the area supplied by the affected nerves, resulting in effective regional anesthesia.

Side Effects

Marcaine Spinal 0,5% Heavy may cause a range of adverse reactions.

Common Side Effects

  • Hypotension: drop in blood pressure after intrathecal injection.
  • Bradycardia: slowed heart rate, especially in high spinal blocks.
  • Nausea and vomiting: gastrointestinal upset following anesthesia.
  • Pruritus: itching, often related to opioid co‑administration.
  • Urinary retention: difficulty voiding after the block.
  • Headache: post‑dural puncture headache in some patients.

Serious or Rare Side Effects

  • Cardiac arrest: severe cardiotoxicity with high plasma levels.
  • Ventricular arrhythmias: life‑threatening rhythm disturbances.
  • Respiratory depression: inadequate ventilation requiring support.
  • Seizures: central nervous system toxicity at excessive doses.
  • Allergic reactions: rash, bronchospasm, or anaphylaxis.
  • Epidural or spinal hematoma: bleeding causing neurologic compromise.

Precautions & Warnings

Before using Marcaine Spinal 0,5% Heavy, clinicians should consider several safety measures.

  • Patient assessment: evaluate cardiovascular status and baseline blood pressure.
  • Dose limitation: avoid excessive intrathecal volume to reduce toxicity risk.
  • Allergy check: confirm no hypersensitivity to amide‑type local anesthetics.
  • Concurrent CNS depressants: use with caution when combined with other sedatives.
  • Monitoring: observe blood pressure, heart rate, and respiratory function during and after injection.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Marcaine Spinal 0,5% Heavy can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may enhance cardiotoxicity.
  • Beta‑blockers: increase risk of bradycardia and hypotension.
  • General anesthetics (e.g., propofol, volatile agents): may potentiate central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Opioids: additive effect on respiratory depression.
  • Sedatives (benzodiazepines): may increase sedation and delay recovery.
  • Magnesium sulfate: can potentiate neuromuscular blockade and affect cardiac conduction.

Frequently Asked Questions

Marcaine Spinal 0,5% Heavy is employed as a local anesthetic to produce spinal anesthesia for surgical procedures. It provides dense sensory and motor blockade, allowing pain‑free operations on the lower abdomen, pelvis, lower limbs, and certain obstetric interventions.

Bupivacaine hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing the influx of sodium ions required for depolarization. This inhibition stops the propagation of nerve impulses, resulting in loss of sensation and muscle relaxation in the targeted region.

The dose is determined by the prescribing clinician based on patient characteristics, type of surgery, and desired block level. A qualified anesthesiologist administers the appropriate intrathecal volume, following institutional protocols and safety guidelines.

Safety data for bupivacaine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Use is generally avoided unless the therapeutic benefit outweighs potential risks, and decisions should follow obstetric and anesthetic expertise.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity and providing institutional credentials. GNH India’s team will verify eligibility, then respond with pricing, availability, shipping arrangements (including any cold‑chain requirements), and the necessary import documentation.

Compared with shorter‑acting agents such as lidocaine, bupivacaine offers a longer duration of anesthesia and a deeper block, making it suitable for prolonged surgeries. However, it carries a higher risk of cardiotoxicity, so careful dosing and monitoring are essential.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Protect the vial from light and moisture, and avoid freezing. Inspect the solution for particulate matter before use and discard if any abnormalities are observed.

Marcaine Spinal is injected into the intrathecal (subarachnoid) space using a sterile spinal needle. The procedure is performed by a trained anesthesiologist in a controlled operating‑room environment, with the patient positioned to facilitate safe needle placement and optimal block distribution.

Serious adverse events include cardiac arrest, severe arrhythmias, respiratory depression, seizures, and allergic reactions such as anaphylaxis. Immediate monitoring of cardiovascular and respiratory parameters is required, and emergency equipment must be readily available during and after administration.

Patients with known hypersensitivity to bupivacaine or other amide‑type local anesthetics, those with severe cardiac conduction disorders, uncontrolled hypotension, or significant coagulopathy should avoid its use. Clinicians must evaluate each individual’s medical history before proceeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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