Product image of Maresyl 0,5 Mg/Ml (Xylometazoline Hydrochloride) supplied by GNH India

Maresyl 0,5 Mg/Ml

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Maresyl 0,5 Mg/Ml (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Maresyl 0,5 Mg/Ml, is an imidazoline nasal decongestant presented as a 0.5 mg/mL nasal solution for nasal use. It relieves nasal congestion associated with the common cold, sinusitis, and allergic rhinitis in adults and children.

GNH India supplies Maresyl 0,5 Mg/Ml as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Jadran-Galenski Laboratorij D.D.

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Indications & Clinical Uses

Xylometazoline Hydrochloride is an imidazoline nasal decongestant that reduces swelling of the nasal mucosa.

  • Common cold: alleviates nasal blockage by decreasing mucosal edema.
  • Sinusitis: improves airflow and eases sinus pressure.
  • Allergic rhinitis: diminishes congestion caused by allergic inflammation.

How It Works

  • Xylometazoline Hydrochloride selectively stimulates α‑adrenergic receptors on the blood vessels of the nasal mucosa, causing vasoconstriction. This reduces blood flow to the area, decreases mucosal edema, and opens the nasal passages, providing rapid relief of congestion without significant systemic absorption.

Side Effects

Xylometazoline Hydrochloride may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nasal irritation: mild burning or stinging sensation.
  • Sneezing: transient increase in sneezing episodes.
  • Dryness of nasal mucosa: feeling of dryness or crusting.
  • Headache: mild headache.

Serious or Rare Side Effects

  • Rebound congestion: worsening nasal blockage after prolonged use.
  • Hypertension: elevated blood pressure in susceptible individuals.
  • Cardiac arrhythmia: irregular heartbeat in rare cases.

Precautions & Warnings

When using Maresyl 0,5 Mg/Ml, certain precautions should be observed to minimize risks.

  • Age limitation: avoid use in children under 6 years unless directed by a healthcare professional.
  • Duration of use: limit treatment to no more than 3–5 consecutive days to prevent rebound congestion.
  • Pre‑existing conditions: use cautiously in patients with hypertension, cardiovascular disease, or thyroid disorders.
  • Pregnancy and lactation: consult a physician before use as safety data are limited.
  • Drug interactions: inform the prescriber of any concurrent nasal or systemic decongestants.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and direct sunlight, and retain in original container.

Avoid Interactions

Xylometazoline Hydrochloride can interact with other medications, primarily affecting cardiovascular and adrenergic pathways.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may potentiate hypertensive effects.
  • Systemic sympathomimetics (e.g., pseudoephedrine): increased risk of hypertension and tachycardia.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: possible attenuation of decongestant effect and altered blood pressure response.
  • Antihypertensive agents: may reduce efficacy of blood pressure control.
  • Tricyclic antidepressants: potential additive cardiovascular stimulation.

Frequently Asked Questions

Maresyl 0,5 Mg/Ml contains Xylometazoline Hydrochloride, an OTC nasal decongestant. It is indicated to relieve nasal blockage caused by the common cold, sinusitis, and allergic rhinitis by reducing swelling of the nasal mucosa. The spray is applied directly into each nostril as directed by a healthcare professional.

Xylometazoline Hydrochloride acts as a selective alpha‑adrenergic agonist. By stimulating α‑adrenergic receptors on the blood vessels of the nasal mucosa, it induces vasoconstriction, which decreases blood flow, reduces edema, and opens the nasal passages, providing rapid relief from congestion.

The appropriate dose of Maresyl 0,5 Mg/mL is determined by the prescribing clinician based on the patient’s age, condition, and response. Typically, a few sprays per nostril are used, but exact instructions should be obtained from a qualified healthcare provider and followed on the product label.

Safety data for Xylometazoline Hydrochloride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their physician before using Maresyl. The prescriber will weigh potential benefits against any possible risks to mother and infant.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Maresyl’s active ingredient, Xylometazoline, belongs to the imidazoline class, which provides rapid vasoconstriction with a relatively low incidence of systemic side effects compared with phenylephrine‑based sprays. It offers similar efficacy to oxymetazoline but may have a slightly longer duration of action, making it a common alternative for short‑term relief.

Maresyl should be stored at ambient temperature, preferably below 25 °C, in its original container. Protect the bottle from moisture, direct sunlight, and extreme temperature fluctuations. Ensure the cap is tightly closed to maintain product stability throughout its shelf life.

Maresyl is a nasal solution intended for intranasal administration. The user tilts the head slightly forward, inserts the nozzle into a nostril, and sprays the prescribed number of actuations. The spray should be directed away from the nasal septum to minimize irritation, and the recommended dose should not be exceeded.

The most serious adverse reactions include rebound nasal congestion (rhinitis medicamentosa) after prolonged use, hypertension, and, rarely, cardiac arrhythmias. Patients experiencing persistent nasal blockage, elevated blood pressure, or irregular heartbeats should discontinue use and seek medical attention promptly.

Maresyl is contraindicated in individuals with known hypersensitivity to Xylometazoline Hydrochloride or any other component of the formulation. It should also be avoided in children under the age recommended by the label, typically under six years, and in patients with severe hypertension or certain cardiovascular disorders unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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