Product image of Marevan (Warfarin Sodium) supplied by GNH India

Marevan

Active Ingredient:
Warfarin Sodium
Origin:
EU

Marevan (Warfarin Sodium)

Warfarin Sodium, the active ingredient in Marevan, is a vitamin K antagonist presented as an oral tablet for oral use. It is used to prevent and treat thromboembolic disorders in adult patients.

GNH India supplies Marevan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mercury Pharmaceuticals Ltd.

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Indications & Clinical Uses

Marevan is a vitamin K antagonist used in the management of various thromboembolic conditions.

  • Atrial fibrillation: reduces the risk of stroke by inhibiting clot formation.
  • Deep vein thrombosis: treats existing clots and prevents recurrence.
  • Pulmonary embolism: facilitates resolution of emboli and prevents new events.
  • Stroke prophylaxis: lowers incidence of ischemic stroke in high‑risk patients.

How It Works

  • Warfarin Sodium inhibits the enzyme vitamin K epoxide reductase, which is essential for recycling vitamin K. This inhibition reduces the regeneration of active vitamin K, thereby decreasing the hepatic synthesis of the vitamin K‑dependent clotting factors II, VII, IX, and X, leading to anticoagulation.

Side Effects

Adverse reactions may occur with any anticoagulant therapy and should be monitored.

Common Side Effects

  • Bruising or minor bleeding.
  • Nosebleeds.
  • Bleeding gums.
  • Blood in urine or stool.
  • Headache.
  • Dizziness.

Serious or Rare Side Effects

  • Severe or uncontrolled bleeding.
  • Hemorrhagic stroke.
  • Skin necrosis.
  • Allergic reactions such as rash or angioedema.
  • Liver dysfunction.
  • Unexplained drop in hemoglobin.

Precautions & Warnings

Warfarin therapy requires careful monitoring and patient education.

  • Monitor INR: regular blood tests are needed to keep INR within the therapeutic range.
  • Adjust diet: consistent intake of vitamin K‑containing foods helps maintain stable anticoagulation.
  • Review medications: many drugs can alter warfarin effect; inform healthcare providers of all medicines.
  • Pregnancy contraindication: warfarin is classified as Pregnancy Category X and should not be used.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Warfarin has numerous drug and food interactions that can affect its anticoagulant effect.

Major Interactions (Avoid)

  • Macrolide antibiotics (e.g., erythromycin): increase warfarin plasma levels.
  • Fluoroquinolone antibiotics (e.g., ciprofloxacin): potentiate anticoagulant effect.
  • Amiodarone: raises warfarin concentration.
  • NSAIDs (e.g., ibuprofen): heighten bleeding risk.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., clopidogrel): additive bleeding risk.
  • Herbal supplements (e.g., ginkgo, garlic): may alter INR.
  • Thyroid hormone therapy: can modify warfarin metabolism.

Frequently Asked Questions

Marevan contains warfarin sodium, a vitamin K antagonist prescribed to prevent and treat thromboembolic disorders such as atrial fibrillation‑related stroke, deep vein thrombosis, and pulmonary embolism. It works by reducing the blood’s ability to clot, thereby lowering the risk of dangerous clots forming or growing.

Warfarin sodium blocks the enzyme vitamin K epoxide reductase, which is needed to recycle vitamin K. Without active vitamin K, the liver produces lower amounts of clotting factors II, VII, IX, and X, resulting in reduced blood coagulation and a lower likelihood of clot formation.

The dose of Marevan is individualized. A qualified prescriber determines the appropriate amount based on the patient’s medical condition, INR monitoring results, and other clinical factors. Patients should follow the prescribing clinician’s instructions and attend regular blood‑test appointments.

Marevan (warfarin sodium) is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to the risk of fetal bleeding and malformations. It is also not recommended while breastfeeding because it can pass into breast milk and affect the infant.

To order Marevan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Marevan (warfarin) is a long‑standing oral vitamin K antagonist, whereas newer agents such as direct oral anticoagulants (DOACs) target specific clotting factors and often require less monitoring. Warfarin offers a reversible effect with vitamin K and has a well‑known interaction profile, making it suitable for patients needing tight control or those with certain renal impairments.

Marevan should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Marevan is taken orally, usually once daily, with or without food as directed by the prescriber. The exact timing and whether it should be taken at the same time each day are determined by the treating clinician based on INR monitoring.

The most serious risks include severe or uncontrolled bleeding, hemorrhagic stroke, and skin necrosis. Patients should immediately report any unusual bruising, blood in urine or stool, severe headache, or signs of allergic reaction to their healthcare provider.

Marevan should not be used by individuals who are pregnant, have uncontrolled hypertension, active major bleeding, recent major surgery, or known hypersensitivity to warfarin. It is also contraindicated in patients with severe liver disease or those taking certain interacting medications without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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