Product image of Marfarin (Warfarin Sodium) supplied by GNH India

Marfarin

Active Ingredient:
Warfarin Sodium
Origin:
EU

Marfarin (Warfarin Sodium)

Warfarin Sodium, the active ingredient in Marfarin, is a Vitamin K antagonist presented as a tablet for oral use. It treats and prevents blood clots such as deep vein thrombosis, pulmonary embolism, and reduces stroke risk in atrial fibrillation and prosthetic heart valve patients.

GNH India supplies Marfarin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

Warfarin Sodium is used to manage conditions related to abnormal blood clot formation.

  • Deep vein thrombosis (DVT): prevents clot extension and recurrence.
  • Pulmonary embolism (PE): treats existing emboli and reduces risk of new events.
  • Atrial fibrillation (AF) stroke prevention: lowers incidence of ischemic stroke in patients with non‑valvular AF.
  • Prosthetic heart valve thrombosis prophylaxis: prevents thromboembolic complications in patients with mechanical heart valves.

How It Works

  • Warfarin Sodium inhibits the enzyme vitamin K epoxide reductase, which is essential for recycling vitamin K. This inhibition reduces the regeneration of active vitamin K, thereby decreasing the hepatic synthesis of the vitamin K‑dependent clotting factors II, VII, IX, and X, leading to anticoagulation.

Side Effects

Common Side Effects

  • Bruising or minor bleeding.
  • Gastrointestinal discomfort or nausea.
  • Headache or dizziness.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Severe or life‑threatening bleeding (intracranial, gastrointestinal).
  • Skin necrosis, especially early in therapy.
  • Allergic reactions including anaphylaxis.
  • Elevated liver enzymes.
  • Purple toe syndrome.
  • Severe cutaneous adverse reactions.

Precautions & Warnings

Warfarin therapy requires careful monitoring and individualized management.

  • Dose adjustment: individualize based on INR monitoring.
  • Drug interactions: review concomitant medications that affect coagulation.
  • Renal/hepatic impairment: use with caution, monitor closely.
  • Pregnancy: contraindicated; avoid use in pregnancy.
  • Bleeding risk: assess patient history of bleeding disorders.
  • Store at ambient temperature: keep tablets in original container, protect from moisture and light.

Avoid Interactions

Warfarin has numerous interactions that can alter its anticoagulant effect.

Major Interactions (Avoid)

  • Acetylsalicylic acid (aspirin): markedly increases bleeding risk.
  • Clopidogrel: additive anticoagulant effect.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): enhance gastrointestinal bleeding.
  • Amiodarone: potentiates warfarin effect, may require dose reduction.

Moderate Interactions (Monitor Closely)

  • Antibiotics (e.g., trimethoprim‑sulfamethoxazole): may increase INR.
  • Antifungals (e.g., fluconazole): can raise warfarin levels.
  • Vitamin K‑rich foods: may reduce anticoagulant effect.

Frequently Asked Questions

Marfarin contains warfarin sodium, an oral anticoagulant used to prevent and treat thromboembolic disorders such as deep vein thrombosis, pulmonary embolism, and to reduce the risk of stroke in patients with atrial fibrillation or mechanical heart valves.

Warfarin Sodium blocks vitamin K epoxide reductase, an enzyme needed to recycle vitamin K. This reduces the production of vitamin K‑dependent clotting factors II, VII, IX, and X, thereby decreasing the blood’s ability to form clots.

The dose of Marfarin is individualized by a healthcare professional. Dosing is guided by regular monitoring of the International Normalized Ratio (INR) to keep anticoagulation within a therapeutic range specific to the patient’s condition.

Warfarin, the active ingredient in Marfarin, is classified as pregnancy category X because it can cause fetal harm and is contraindicated during pregnancy. Use while breastfeeding is generally not recommended unless the benefit outweighs the risk and is decided by a physician.

To order Marfarin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Marfarin (warfarin) is a vitamin K antagonist that requires INR monitoring and has many dietary and drug interactions. Direct oral anticoagulants (DOACs) such as apixaban or rivaroxaban have more predictable pharmacokinetics and do not need routine monitoring, but warfarin remains useful for patients with mechanical heart valves or severe renal impairment.

Store Marfarin tablets at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and do not use if the packaging is damaged.

Marfarin is taken orally as a tablet, usually once daily. It can be taken with or without food, but consistency with meals helps maintain stable absorption. Patients should follow the prescribing physician’s instructions regarding timing and any required dietary considerations.

The most serious risks include severe or life‑threatening bleeding (such as intracranial or gastrointestinal hemorrhage), skin necrosis, and rare allergic reactions. Patients should seek immediate medical attention if they notice unusual bruising, blood in urine or stool, severe headache, or skin discoloration.

Marfarin should not be used by individuals who are pregnant, have active major bleeding, recent major surgery, uncontrolled hypertension, severe liver disease, or known hypersensitivity to warfarin. It is also contraindicated in patients with certain clotting factor deficiencies unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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