Product image of Margot (Drospirenone, Ethinylestradiol) supplied by GNH India

Margot

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Margot (Drospirenone, Ethinylestradiol)

Drospirenone and ethinylestradiol, the active ingredients in Margot, are a combined oral contraceptive presented as a tablet for oral use. It prevents pregnancy in women of reproductive age.

GNH India supplies Margot as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Exeltis Germany Gmbh

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Indications & Clinical Uses

Margot, a combined oral contraceptive, is used to prevent pregnancy by suppressing ovulation.

  • Prevention of pregnancy: provides reliable contraception for women of childbearing age.
  • Management of menstrual-related symptoms: helps regulate menstrual cycles and reduce dysmenorrhea.
  • Treatment of acne: may improve acne associated with androgen excess.

How It Works

  • Drospirenone and ethinylestradiol act together to inhibit the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH), thereby preventing ovulation. The estrogen component stabilises the endometrium, while the progestin component thickens cervical mucus and alters endometrial receptivity, reducing the likelihood of fertilisation and implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Headache: occasional throbbing pain.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or mood swings.
  • Spotting: irregular vaginal bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins.
  • Arterial thrombosis: clot formation in arteries, potentially leading to stroke.
  • Hypertension: elevated blood pressure.
  • Liver disorders: jaundice or hepatic dysfunction.
  • Gallbladder disease: gallstones or cholecystitis.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before using Margot, consider the following precautions:

  • Pregnancy: contraindicated; do not use if pregnant.
  • Smoking: avoid if over 35 years and smoking >15 cigarettes per day.
  • Thromboembolic history: avoid if personal or family history of blood clots.
  • Liver disease: use with caution in hepatic impairment.
  • Hypertension: monitor blood pressure regularly.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Margot may interact with several medicines.

Major Interactions (Avoid)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): reduce contraceptive effectiveness.
  • Antifungal agents (e.g., ketoconazole): increase hormone levels, risk of side effects.
  • St. John’s wort: may diminish contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs): may increase risk of mood changes.
  • Anticonvulsants (phenytoin): may alter hormone metabolism.
  • Antihypertensives: monitor blood pressure for additive effects.
  • Herbal supplements (ginkgo): potential platelet effects.
  • Diuretics: may affect electrolyte balance.

Frequently Asked Questions

Margot is a combined oral contraceptive containing drospirenone and ethinylestradiol. It is prescribed to prevent pregnancy in women of reproductive age and may also be used to manage menstrual‑related symptoms and certain acne conditions.

The combination suppresses the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH), which stops ovulation. Drospirenone thickens cervical mucus and alters the endometrium, while ethinylestradiol stabilises the uterine lining, together reducing the chance of fertilisation and implantation.

The dosing regimen for Margot is determined by the prescribing healthcare professional. Typically, it is taken as one tablet daily at the same time each day, but the exact schedule and any missed‑dose instructions should follow the prescriber’s guidance.

Margot is contraindicated during pregnancy and should be stopped if pregnancy occurs. Its safety during breastfeeding has not been established; healthcare providers usually advise alternative contraception for nursing mothers.

To order Margot, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Margot contains drospirenone, a progestin with anti‑androgenic and mild diuretic properties, which may offer benefits such as reduced water retention and acne improvement compared with some other progestins. Efficacy in preventing pregnancy is comparable across approved combined oral contraceptives.

Store Margot tablets at room temperature, below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain tablet integrity.

Margot is taken orally as a tablet. The usual practice is to swallow one tablet each day, preferably at the same time, with or without food, following the prescriber’s instructions for the start of a new pack.

Serious risks include venous or arterial thromboembolism, hypertension, liver disorders, and severe allergic reactions. Women with a history of blood clots, smoking over 15 cigarettes per day after age 35, or certain cardiovascular conditions should discuss these risks with their healthcare provider.

Margot should not be used by women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic disorders, uncontrolled hypertension, severe liver disease, or who are smokers over the age of 35. Contraindications must be confirmed by a qualified prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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