Product image of Maricrio (Omeprazole) supplied by GNH India

Maricrio

Active Ingredient:
Omeprazole
Origin:
EU

Maricrio (Omeprazole)

Omeprazole, the active ingredient in Maricrio, is a proton pump inhibitor presented as a standard strength tablet for oral use. It reduces gastric acid secretion and is employed to treat gastro‑oesophageal reflux disease, peptic ulcer disease, erosive esophagitis and as part of Helicobacter pylori eradication regimens in adult patients.

GNH India supplies Maricrio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Neopharmed Gentili Spa

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Indications & Clinical Uses

  • Omeprazole is a proton pump inhibitor used to manage acid‑related gastrointestinal conditions.
  • Gastro‑oesophageal reflux disease (GERD): reduces acid exposure, relieving heartburn and promoting healing of the esophageal lining.
  • Peptic ulcer disease: suppresses gastric acid to allow ulcer healing and prevent recurrence.
  • Erosive esophagitis: decreases acid‑induced inflammation, facilitating mucosal repair.
  • Helicobacter pylori eradication regimens: enhances the effectiveness of antibiotic combinations by maintaining a less acidic gastric environment.

How It Works

  • Omeprazole selectively and irreversibly binds to the H⁺/K⁺‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By inhibiting this final step of acid production, it markedly lowers both basal and stimulated gastric acid secretion, leading to an increase in gastric pH and providing a protective environment for ulcer healing and symptom relief.

Side Effects

Omeprazole may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Diarrhea: loose stools occurring intermittently.
  • Nausea: feeling of stomach discomfort or urge to vomit.
  • Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis presenting with watery diarrhea.
  • Bone fracture: increased risk of hip, wrist or spine fractures with long‑term use.
  • Hypomagnesemia: low serum magnesium causing muscle weakness or cardiac arrhythmia.
  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

When prescribing or dispensing omeprazole, several precautions should be observed to ensure safe use.

  • Assess renal and hepatic function: dose adjustment may be needed in severe impairment.
  • Long‑term therapy monitoring: evaluate need for continued treatment to avoid unnecessary exposure.
  • Drug interaction review: check concomitant medications that may affect acid levels or omeprazole metabolism.
  • Pregnancy and lactation counseling: discuss potential risks and benefits with the patient.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Omeprazole can alter the pharmacokinetics of several medicines; interactions are categorized by clinical significance.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, may increase cardiovascular risk.
  • Atazanavir or other protease inhibitors: markedly decreased absorption, compromising antiviral efficacy.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential increase in INR, monitor coagulation parameters.
  • Diazepam: increased plasma levels, observe for enhanced sedation.
  • Methotrexate (high dose): reduced renal clearance, watch for toxicity.

Frequently Asked Questions

Maricrio, containing omeprazole, is indicated for the treatment of gastro‑oesophageal reflux disease (GERD), peptic ulcer disease, erosive esophagitis, and as part of combination regimens aimed at eradicating Helicobacter pylori infection. These conditions share a common feature of excessive gastric acid production, which the drug helps to control.

Omeprazole acts by binding irreversibly to the H⁺/K⁺‑ATPase enzyme, also known as the gastric proton pump, on the surface of parietal cells. This inhibition blocks the final step of acid secretion, leading to a sustained increase in gastric pH and a reduction in both basal and stimulated acid output.

The appropriate dose of Maricrio is determined by the prescribing healthcare professional based on the specific indication, patient characteristics, and clinical response. Patients should follow the dosage instructions provided by their prescriber and not adjust the amount without medical guidance.

Safety data for omeprazole during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the Maricrio product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Maricrio (omeprazole) belongs to the same class as esomeprazole, lansoprazole, pantoprazole and rabeprazole. All share a similar mechanism of inhibiting the gastric proton pump, but they differ slightly in pharmacokinetic profiles, potency and drug‑interaction potential. Choice of agent often depends on physician preference, patient response, and specific interaction considerations.

Maricrio tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Maricrio is taken orally, usually as a whole tablet swallowed with a glass of water. It is generally recommended to take the medication before a meal, often in the morning, unless the prescriber advises a different schedule based on the therapeutic goal.

Serious but uncommon risks include Clostridioides difficile‑associated colitis, severe allergic reactions such as anaphylaxis, hypomagnesemia with long‑term use, and an increased incidence of bone fractures. Patients should seek immediate medical attention if they experience persistent diarrhea, severe rash, swelling, or unexplained muscle weakness.

Maricrio should be avoided in individuals with a known hypersensitivity to omeprazole or any component of the formulation. Caution is also advised for patients with severe liver disease, those taking medications that rely on gastric acidity for absorption, and patients with a history of certain bone disorders when used long‑term.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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