Martifen (Flurbiprofen)

Flurbiprofen acts as an NSAID to manage pain and inflammatory disorders. It is indicated for the following conditions:

• Mild to moderate pain: provides analgesic relief for acute or chronic pain states.
• Rheumatoid arthritis: reduces joint inflammation and pain, improving functional ability.
• Osteoarthritis: alleviates joint discomfort and stiffness associated with degenerative disease.
• Musculoskeletal pain: eases soreness and inflammation of muscles, tendons and ligaments.

• Flurbiprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition decreases the conversion of arachidonic acid to prostaglandins, leading to reduced synthesis of mediators that promote inflammation, pain and fever.

Flurbiprofen may cause a range of adverse reactions. The most frequently reported events are generally mild and reversible.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia, abdominal discomfort.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or pruritus.
• Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Cardiovascular events such as myocardial infarction or stroke.
• Acute renal impairment or failure.
• Severe skin reactions (e.g., Stevens‑Johnson syndrome).
• Hepatic failure or jaundice.
• Anaphylactic or anaphylactoid reactions.

When prescribing or dispensing Flurbiprofen, consider the following safety measures:

• Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
• Monitor renal function: use caution in patients with impaired kidney function or dehydration.
• Evaluate cardiovascular risk: limit use in patients with established heart disease or uncontrolled hypertension.
• Use the lowest effective dose for the shortest duration necessary.
• Avoid in individuals with known hypersensitivity to flurbiprofen or other NSAIDs.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Flurbiprofen can interact with several drug classes, affecting efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened risk of ulceration and bleeding.
• ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.

Moderate Interactions (Monitor Closely)

• Diuretics: may enhance renal adverse effects.
• Methotrexate: potential for increased toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding risk.
• Antihypertensive agents: possible attenuation of blood pressure control.