Masdil Retard (Diltiazem Hydrochloride)

Diltiazem hydrochloride blocks L‑type calcium channels in cardiac muscle and vascular smooth muscle. This inhibition reduces calcium entry into cells, leading to decreased myocardial contractility, slowed atrioventricular nodal conduction, and vasodilation of arterial vessels. The combined effect lowers heart rate, cardiac output, and peripheral resistance, providing antihypertensive and anti‑anginal benefits.

The exact dosage of Masdil Retard is determined by the prescribing physician according to the patient’s clinical condition, response to therapy, and any concomitant medications. Doses are individualized and may be adjusted during treatment; patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Safety data for diltiazem hydrochloride in pregnancy are limited, and the drug is generally classified as contraindicated or to be used only when the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should consult their healthcare provider before using Masdil Retard.

To request Masdil Retard, visit the product page on gnhindia.com, enter the desired quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing a quotation, availability, shipping details, and required import documentation.

Masdil Retard, as an extended‑release formulation of diltiazem, offers a once‑daily dosing schedule and a balanced profile of cardiac and vascular effects. Compared with dihydropyridine agents such as amlodipine, diltiazem has more pronounced effects on heart rate and AV nodal conduction, making it useful for patients who also need rate control in addition to blood‑pressure reduction.

Masdil Retard tablets should be stored at ambient temperature, preferably below 25 °C, in their original blister pack or container. Protect the product from moisture, direct sunlight, and excessive heat to maintain stability. Keep the medication out of reach of children and do not use after the expiration date.

Masdil Retard is taken orally, usually once daily in the morning, with or without food, as directed by the prescriber. The extended‑release tablet should be swallowed whole; it must not be split, chewed, or crushed, as this could alter the release profile and affect efficacy and safety.

The most serious adverse reactions to diltiazem include severe bradycardia, atrioventricular heart block, and profound hypotension, which can be life‑threatening if not promptly recognized. Patients should be monitored for signs of these events, especially when initiating therapy or when combined with other drugs that affect heart rate or blood pressure.

Masdil Retard is contraindicated in patients with known hypersensitivity to diltiazem or any component of the formulation, in those with severe hypotension, sick sinus syndrome, or second‑ or third‑degree AV block without a pacemaker. Caution is also advised for individuals with severe hepatic impairment or unstable heart failure, and the drug should be avoided unless medically justified.