Product image of Massido (Nebivolol) supplied by GNH India

Massido

Active Ingredient:
Nebivolol
Origin:
EU

Massido (Nebivolol)

Nebivolol, the active ingredient in Massido, is a beta blocker presented as a tablet for oral use. It treats hypertension in adult patients.
GNH India supplies Massido as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alkaloid-Int D.O.O.

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Indications & Clinical Uses

  • Nebivolol is indicated for the management of high blood pressure, acting on the cardiovascular system to lower systemic pressure.
  • Hypertension: reduces systolic and diastolic blood pressure in patients with essential hypertension.

How It Works

  • Nebivolol selectively blocks β1‑adrenergic receptors in cardiac tissue, decreasing heart rate and contractility. It also enhances nitric oxide release from endothelial cells, causing vasodilation and further lowering peripheral vascular resistance, which together contribute to blood‑pressure reduction.

Side Effects

Nebivolol may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Fatigue: feeling unusually tired or weak.
  • Nausea: upset stomach or urge to vomit.
  • Bradycardia: slower than normal heart rate.
  • Peripheral edema: swelling of the ankles or feet.

Serious or Rare Side Effects

  • Severe bradycardia: markedly low heart rate requiring medical attention.
  • Symptomatic hypotension: dangerously low blood pressure causing faintness.
  • Acute heart failure exacerbation: worsening of cardiac function.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Liver injury: abnormal liver function tests or jaundice.
  • Bronchospasm: narrowing of airways, especially in patients with asthma.

Precautions & Warnings

Nebivolol requires careful monitoring and specific safety measures before and during therapy.

  • Blood pressure monitoring: check regularly to ensure therapeutic targets are met.
  • Hepatic impairment: use cautiously in patients with severe liver disease.
  • Abrupt discontinuation: taper dose to avoid rebound hypertension.
  • Respiratory conditions: avoid in uncontrolled asthma or severe COPD.
  • Drug interactions: review concomitant medications for potential additive effects.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and light.

Avoid Interactions

Nebivolol can interact with several medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Other β‑blockers: may cause excessive bradycardia or hypotension.
  • Calcium‑channel blockers (verapamil, diltiazem): increase nebivolol plasma levels.
  • CYP2D6 inhibitors (paroxetine, fluoxetine): raise nebivolol concentrations.
  • Insulin or sulfonylureas: mask hypoglycaemic symptoms.
  • Antihypertensive combinations: risk of additive blood‑pressure lowering.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce antihypertensive effect.
  • Diuretics: monitor electrolytes and renal function.
  • Antidepressants (sertraline): observe for heart‑rate changes.
  • Antidiabetic agents: watch for altered glucose control.
  • Lipid‑lowering drugs (statins): assess for rare muscle toxicity.

Frequently Asked Questions

Massido contains nebivolol, which is prescribed to lower high blood pressure in adults. By reducing systemic vascular resistance and heart rate, it helps achieve target blood‑pressure levels and lowers the risk of cardiovascular complications associated with hypertension.

Nebivolol selectively blocks β1‑adrenergic receptors in the heart, decreasing heart rate and contractility. It also stimulates endothelial nitric oxide release, causing vasodilation. The combined effect reduces cardiac output and peripheral resistance, resulting in lower arterial pressure.

The dosage of Massido is individualized by a qualified prescriber based on the patient’s clinical condition, blood‑pressure response, and tolerability. The prescribing physician determines the appropriate strength, frequency, and any titration schedule.

Nebivolol is generally classified as a pregnancy‑category drug with limited safety data. It should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as the drug may be excreted in milk.

To request Massido, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Nebivolol offers a unique combination of β1‑blockade and nitric‑oxide‑mediated vasodilation, which can provide better tolerability and fewer metabolic side effects compared with traditional non‑selective β‑blockers. It is often considered alongside ACE inhibitors, ARBs, or calcium‑channel blockers based on patient profile.

Massido tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use after the expiry date indicated on the label.

Massido is taken orally, usually with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water and follow the dosing schedule provided on the prescription label.

Serious risks include severe bradycardia, symptomatic hypotension, acute heart‑failure exacerbation, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, rapid weight gain, swelling, or signs of an allergic response.

Massido is contraindicated in patients with known hypersensitivity to nebivolol or any excipients, those with severe bradycardia, second‑ or third‑degree atrioventricular block without a pacemaker, and individuals in cardiogenic shock. Caution is also advised for patients with uncontrolled asthma or severe COPD.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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