Master Aid Disinfettante (Chlorhexidine Gluconate)

Chlorhexidine gluconate is an antiseptic used for skin antisepsis and wound care.

• Skin antisepsis: lowers microbial load on intact skin before invasive procedures.
• Pre‑operative skin preparation: cleans the surgical site to reduce infection risk.
• Wound cleaning: disinfects minor cuts, abrasions and superficial burns.

• Chlorhexidine gluconate exerts its antimicrobial effect by binding to bacterial cell membranes, disrupting membrane integrity and causing leakage of intracellular components, which leads to cell death. The cationic molecule also precipitates cytoplasmic proteins, enhancing its broad‑spectrum activity against Gram‑positive and Gram‑negative bacteria, some fungi and enveloped viruses.

Adverse reactions may occur with topical chlorhexidine use.

Common Side Effects

• Skin irritation: redness or mild burning at the application site.
• Itching: localized pruritus after exposure.
• Dryness: transient loss of skin moisture.
• Contact dermatitis: mild allergic skin reaction.
• Stinging sensation: brief discomfort on application.
• Redness: mild erythema.

Serious or Rare Side Effects

• Anaphylaxis: severe systemic allergic reaction requiring emergency care.
• Chemical burns: deep tissue injury with prolonged exposure.
• Stevens‑Johnson syndrome: rare severe skin eruption.
• Contact urticaria: hives at the site of contact.
• Systemic toxicity: rare absorption leading to organ effects.
• Mucosal irritation: severe irritation if applied to eyes or mucous membranes.

When using Master Aid Disinfettante, follow these safety measures.

• Avoid use on mucous membranes: limit application to intact skin only.
• Do not apply to large open wounds: risk of systemic absorption.
• Perform a patch test: apply a small amount to check for hypersensitivity.
• Keep away from eyes: accidental contact may cause irritation.
• Do not combine with other antiseptics containing alcohol or iodine: may increase irritation.
• Store at room temperature: keep in the original container, protect from light and moisture.

Chlorhexidine gluconate may interact with certain topical agents and systemic drugs.

Major Interactions (Avoid)

• Alcohol‑based antiseptics: can cause increased skin irritation.
• Iodine preparations: may reduce antiseptic efficacy.
• Silver‑containing dressings: can inactivate chlorhexidine.
• Anionic soaps or detergents: may neutralize the cationic action.

Moderate Interactions (Monitor Closely)

• Systemic antibiotics: heightened risk of hypersensitivity reactions.
• Latex medical devices: possible cross‑reactivity in sensitive individuals.
• Other skin care products: may alter absorption or cause irritation.