Product image of Mastical D 500 Sabor Fresa (Colecalciferol, Calcium) supplied by GNH India

Mastical D 500 Sabor Fresa

Active Ingredient:
Colecalciferol, Calcium
Origin:
EU

Mastical D 500 Sabor Fresa (Colecalciferol, Calcium)

Colecalciferol, the active ingredient in Mastical D 500 Sabor Fresa, is a Vitamin D3 and Calcium supplement presented as an oral tablet for oral use. It helps correct vitamin D and calcium deficiencies and supports normal bone mineralization in children and adults.

GNH India supplies Mastical D 500 Sabor Fresa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Mastical D 500 Sabor Fresa is used to address conditions related to insufficient vitamin D or calcium intake.

  • Vitamin D deficiency: restores serum 25‑hydroxyvitamin D levels, reducing risk of osteomalacia.
  • Calcium deficiency: increases dietary calcium absorption, helping maintain normal serum calcium.
  • Osteoporosis prevention: provides nutrients that support bone mineral density in at‑risk populations.
  • Secondary hyperparathyroidism: aids in normalizing parathyroid hormone levels by improving calcium balance.

How It Works

  • Colecalciferol (vitamin D3) is converted in the liver to 25‑hydroxyvitamin D and subsequently in the kidney to the active hormone 1,25‑dihydroxyvitamin D, which binds to nuclear vitamin D receptors. This complex up‑regulates transcription of calcium‑binding proteins, enhancing intestinal absorption of calcium and phosphate and promoting bone mineralization.

Side Effects

Adverse reactions to Mastical D 500 Sabor Fresa are generally mild but may occur.

Common Side Effects

  • Nausea
  • Constipation
  • Mild abdominal discomfort
  • Headache
  • Mild hypercalcemia

Serious or Rare Side Effects

  • Severe hypercalcemia with confusion or cardiac arrhythmia
  • Allergic reactions such as rash, urticaria or angioedema
  • Kidney stones due to calcium precipitation
  • Hypervitaminosis D leading to soft‑tissue calcification

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Assess baseline vitamin D and calcium levels: measure serum 25‑hydroxyvitamin D and calcium before starting treatment.
  • Adjust dose in renal impairment: monitor serum calcium closely in patients with reduced kidney function.
  • Avoid in hypercalcemia: discontinue if serum calcium is elevated.
  • Caution in sarcoidosis or granulomatous disease: these conditions may increase vitamin D activation.
  • Monitor for signs of toxicity: watch for persistent nausea, vomiting, polyuria, or mental status changes.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mastical D 500 Sabor Fresa may interact with several medicines.

Major Interactions (Avoid)

  • Thiazide diuretics: may exacerbate hypercalcemia.
  • Excess vitamin A: combined high doses increase risk of hypercalcemia.
  • Calcium‑containing antacids: can lead to excessive calcium intake.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase calcium loss, requiring monitoring.
  • Corticosteroids: can reduce calcium absorption, may need dose adjustment.
  • Anticonvulsants (e.g., phenytoin, phenobarbital): may enhance vitamin D metabolism, lowering effectiveness.

Frequently Asked Questions

Mastical D 500 Sabor Fresa is an oral nutritional supplement that provides colecalciferol (vitamin D3) and calcium. It is used to correct vitamin D and calcium deficiencies, support normal bone mineralization, and help prevent conditions such as osteomalacia and osteoporosis in individuals with inadequate dietary intake.

Colecalciferol (vitamin D3) is first hydroxylated in the liver to 25‑hydroxyvitamin D and then in the kidney to the active form 1,25‑dihydroxyvitamin D. This active hormone binds to nuclear vitamin D receptors, stimulating the synthesis of calcium‑binding proteins that increase intestinal absorption of calcium and phosphate, essential for bone formation and remodeling.

The appropriate dose of Mastical D 500 Sabor Fresa is individualized by a qualified healthcare professional based on factors such as the patient’s age, baseline vitamin D and calcium levels, underlying medical conditions, and concurrent medications. The prescriber will set the specific regimen that best meets the patient’s therapeutic needs.

Vitamin D and calcium are essential nutrients during pregnancy and lactation, but the safety of any supplement depends on the dose. Mastical D 500 Sabor Fresa should only be used in these periods if a healthcare provider has evaluated the mother’s nutritional status and determined that the supplement’s dosage is appropriate and does not exceed recommended limits.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Mastical D 500 Sabor Fresa combines colecalciferol with calcium, offering a dual‑nutrient approach, whereas many vitamin D products contain only the vitamin. This combination can be advantageous for patients who need both nutrients for bone health. However, if a patient already receives adequate calcium from diet or other sources, a vitamin‑D‑only product may be preferred to avoid excess calcium intake.

Store the tablets at ambient temperature, below 25 °C, in the original container to protect them from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme heat or humidity, which could affect potency.

Mastical D 500 Sabor Fresa is taken orally, usually with water. The tablet should be swallowed whole and not chewed or crushed unless a healthcare professional advises otherwise. It can be taken with or without food, but consistency with meals may improve absorption of the vitamin D component.

The most serious risks involve excessive calcium or vitamin D levels. Severe hypercalcemia can cause confusion, cardiac arrhythmias, and kidney damage. Hypervitaminosis D may lead to soft‑tissue calcification, particularly in the kidneys, heart, and blood vessels. Prompt medical evaluation is required if symptoms such as persistent nausea, vomiting, excessive thirst, or neurological changes appear.

Individuals with known hypersensitivity to colecalciferol, calcium, or any excipients in the tablet should avoid the product. It is also contraindicated in patients with documented hypercalcemia, severe renal impairment, sarcoidosis, or other granulomatous diseases that predispose to uncontrolled vitamin D activation. Consultation with a healthcare provider is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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