Mastical D Sabor Naranja (Colecalciferol, Calcium)

Mastical D Sabor Naranja is used to address conditions related to inadequate vitamin D or calcium status.

• Vitamin D deficiency: improves serum 25‑hydroxyvitamin D levels to support calcium homeostasis.
• Calcium deficiency: supplies elemental calcium for bone mineralization and maintenance.
• Osteopenia/osteoporosis risk: contributes to bone health by providing both vitamin D and calcium needed for skeletal strength.

• Colecalciferol (vitamin D3) is metabolized in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D, which binds to intracellular vitamin D receptors, up‑regulating calcium‑binding proteins and enhancing intestinal absorption of calcium and phosphate. The calcium component provides elemental calcium that is incorporated into bone during remodeling.

Adverse reactions to Mastical D Sabor Naranja are generally mild but may occur.

Common Side Effects

• Nausea: mild stomach upset after ingestion.
• Constipation: reduced bowel movements.
• Abdominal discomfort: cramping or bloating.
• Hypercalcemia symptoms: mild fatigue or thirst.

Serious or Rare Side Effects

• Severe hypercalcemia: confusion, arrhythmia, or kidney stones.
• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Hypervitaminosis D: vomiting, weakness, and markedly elevated serum calcium.

Before using Mastical D Sabor Naranja, consider the following precautions.

• Assess baseline serum calcium: ensure levels are within normal range to avoid excess.
• Monitor renal function: patients with kidney disease may have altered calcium handling.
• Avoid in hypercalcemia: discontinue if serum calcium is elevated.
• Caution in sarcoidosis or granulomatous disease: increased conversion to active vitamin D can raise calcium.
• Review concomitant medications: especially thiazide diuretics or lithium which affect calcium balance.
• Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Mastical D Sabor Naranja may interact with several medicines; awareness of major and moderate interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

• Thiazide diuretics: can increase risk of hypercalcemia.
• Vitamin D intoxication: concurrent high‑dose vitamin D supplements may cause toxicity.
• Calcium‑containing antacids: may lead to excessive calcium intake.

Moderate Interactions (Monitor Closely)

• Lithium: vitamin D can raise lithium levels, requiring monitoring.
• Bisphosphonates: calcium supplements may reduce absorption if taken simultaneously; separate dosing by at least 2 hours.
• Corticosteroids: may reduce calcium absorption, necessitating dose adjustment.