Mastoprofen (Progesterone)

• Mastoprofen (progesterone) is used in hormone‑related conditions where progesterone activity is required.
• Menopausal hormone therapy: helps alleviate vasomotor symptoms and provides endometrial protection.
• Luteal phase support: supplies progesterone to sustain early pregnancy in assisted reproductive cycles.
• Premenstrual syndrome: reduces mood swings, breast tenderness and other cyclic discomforts.

• Progesterone binds to intracellular progesterone receptors, forming a hormone‑receptor complex that translocates to the nucleus and modulates gene transcription. This influences the growth and differentiation of reproductive tissues, regulates the menstrual cycle, and contributes to the maintenance of hormonal equilibrium in the body.

Progesterone applied topically can cause a range of reactions, most of which are mild and reversible.

Common Side Effects

• Skin irritation or redness at the application site
• Itching or mild rash
• Breast tenderness or swelling
• Headache
• Nausea or mild gastrointestinal upset
• Fatigue or drowsiness

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis, angioedema)
• Extensive skin blistering or necrosis
• Thromboembolic events (deep vein thrombosis, pulmonary embolism)
• Hepatic enzyme abnormalities
• Adrenal insufficiency with prolonged use
• Unexplained vaginal bleeding

• When using Mastoprofen, consider the following safety measures.
• Pregnancy: use only under direct medical supervision, as progesterone may affect fetal development.
• Breastfeeding: consult a healthcare professional before application.
• Hormone‑sensitive conditions: avoid if you have a history of estrogen‑dependent tumors.
• Drug interactions: review all concomitant medications with your prescriber.
• Skin integrity: do not apply to broken, infected, or inflamed skin.
• Store at ambient temperature: keep in the original container, protect from moisture and direct light.

Progesterone can interact with several medicines; categorize the risk level.

Major Interactions (Avoid)

• Combined oral contraceptives: may increase thromboembolic risk.
• Antifungal azoles (e.g., ketoconazole): can raise systemic progesterone levels.
• Strong CYP3A4 inhibitors (e.g., itraconazole): may elevate exposure and side‑effect potential.

Moderate Interactions (Monitor Closely)

• CYP3A4 inducers (e.g., rifampicin): may reduce progesterone effectiveness.
• Anticoagulants (e.g., warfarin): progesterone may enhance anticoagulant effect.
• Glucocorticoids: concurrent use may alter hormonal balance and require monitoring.