Product image of Masultab (Amisulpride) supplied by GNH India

Masultab

Active Ingredient:
Amisulpride
Origin:
EU

Masultab (Amisulpride)

Amisulpride, the active ingredient in Masultab, is an atypical antipsychotic presented as an oral tablet for oral use. It is indicated for the treatment of schizophrenia and acute psychotic episodes in adult patients.
GNH India supplies Masultab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

Amisulpride is an atypical antipsychotic used within the schizophrenia and psychosis therapeutic pathway.

  • Schizophrenia: reduces positive and negative psychotic symptoms and helps maintain long‑term stability.
  • Acute psychotic episodes: alleviates sudden onset of hallucinations, delusions and agitation.
  • Maintenance therapy for schizophrenia: supports ongoing symptom control and relapse prevention.

How It Works

  • Amisulpride selectively antagonises dopamine D2 and D3 receptors. At low oral doses it blocks presynaptic dopamine autoreceptors, enhancing dopamine release, while at higher doses it blocks postsynaptic receptors, diminishing dopaminergic neurotransmission and thereby reducing psychotic manifestations.

Side Effects

Amisulpride may cause a range of adverse reactions.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Weight gain: modest increase in body weight.
  • Extrapyramidal symptoms: tremor, rigidity or restlessness.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity.
  • Tardive dyskinesia: persistent involuntary movements after prolonged use.
  • Severe hypotension: marked drop in blood pressure, especially on standing.
  • Agranulocytosis: dangerous reduction in white blood cells, increasing infection risk.

Precautions & Warnings

Before initiating Masultab, clinicians should consider several safety measures.

  • Monitor for extrapyramidal symptoms: assess movement disorders regularly.
  • Assess cardiac function: evaluate QT interval and baseline ECG.
  • Use caution in renal impairment: adjust dose if renal function is reduced.
  • Avoid abrupt discontinuation: taper gradually to minimise withdrawal effects.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Amisulpride can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Co‑administration with other dopamine antagonists: may amplify antipsychotic effects and side‑effects.
  • Concomitant use with QT‑prolonging agents: increases risk of cardiac arrhythmias.
  • Combination with strong CYP2D6 inhibitors: can raise plasma levels of amisulpride.

Moderate Interactions (Monitor Closely)

  • Use with anticholinergic agents: may increase anticholinergic burden and cognitive effects.
  • Concurrent CNS depressants: may enhance sedation or respiratory depression.
  • Alcohol consumption: can intensify dizziness and orthostatic hypotension.

Frequently Asked Questions

Masultab contains the active ingredient amisulpride and is prescribed for adults with schizophrenia and for the management of acute psychotic episodes. It helps reduce hallucinations, delusions, and other positive symptoms, and can be used as maintenance therapy to prevent relapse in stable patients.

Amisulpride works by selectively blocking dopamine D2 and D3 receptors. At low doses it blocks presynaptic autoreceptors, increasing dopamine release, while at higher doses it blocks postsynaptic receptors, decreasing dopaminergic activity that contributes to psychotic symptoms.

The appropriate dose of Masultab is determined by the prescribing clinician based on the individual patient's condition, response, and tolerability. Dosage may be adjusted over time, and patients should follow the specific instructions provided by their healthcare professional.

Safety data for amisulpride in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant, and decisions should be made in consultation with a qualified healthcare provider.

To order Masultab, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Masultab (amisulpride) is an atypical antipsychotic that primarily targets dopamine D2/D3 receptors, offering a distinct side‑effect profile compared with agents such as risperidone or olanzapine. It may cause fewer metabolic changes but has a higher propensity for extrapyramidal symptoms at certain doses.

Masultab tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Masultab is taken orally, usually with water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional. Dosing times and frequency are set by the prescriber.

Serious risks include neuroleptic malignant syndrome, tardive dyskinesia, severe hypotension, and agranulocytosis. Patients should seek immediate medical attention if they experience high fever, muscle rigidity, unexplained bruising, persistent low blood pressure, or signs of infection.

Masultab is contraindicated in patients with known hypersensitivity to amisulpride or any excipients in the tablet. It should also be avoided in individuals with a history of severe cardiac arrhythmias, uncontrolled epilepsy, or those currently receiving dopamine‑blocking agents that could cause additive effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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