Product image of Matepil (Quetiapine) supplied by GNH India

Matepil

Active Ingredient:
Quetiapine
Origin:
EU

Matepil (Quetiapine)

Quetiapine, the active ingredient in Matepil, is a atypical antipsychotic presented as a oral tablet for oral use. It treats schizophrenia, bipolar disorder (both manic and depressive phases) and is used as an adjunct in major depressive disorder in adult patients.

GNH India supplies Matepil as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gap S.A.

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Indications & Clinical Uses

Quetiapine is an atypical antipsychotic used to manage several psychiatric conditions.

  • Schizophrenia: reduces psychotic symptoms and lowers relapse risk.
  • Bipolar disorder (manic episodes): stabilises mood and prevents mania.
  • Bipolar disorder (depressive episodes): alleviates depressive symptoms.
  • Adjunct treatment of major depressive disorder: enhances response to primary antidepressants.

How It Works

  • Quetiapine acts as an antagonist at serotonin 5‑HT2A, dopamine D2, histamine H1 and adrenergic α1 receptors, while providing partial agonist activity at 5‑HT1A receptors. This receptor profile modulates neurotransmission, leading to antipsychotic, mood‑stabilising and anxiolytic effects in the central nervous system.

Side Effects

Quetiapine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Sedation or somnolence.
  • Dizziness, especially on standing.
  • Dry mouth.
  • Constipation.
  • Weight gain.
  • Orthostatic hypotension.

Serious or Rare Side Effects

  • Agranulocytosis.
  • Neuroleptic malignant syndrome.
  • Tardive dyskinesia.
  • Suicidal thoughts or behaviours.
  • Severe hypotension or cardiac arrhythmia.
  • Hepatic dysfunction.

Precautions & Warnings

When prescribing quetiapine, clinicians should consider several safety measures.

  • Monitor metabolic parameters: weight, glucose and lipid levels.
  • Assess for suicidal ideation, especially early in treatment.
  • Evaluate cardiovascular status: risk of orthostatic hypotension.
  • Use caution in elderly patients due to increased fall risk.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Quetiapine can interact with other medicines, requiring attention to avoid reduced efficacy or heightened toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase quetiapine plasma levels.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce quetiapine effectiveness.
  • Concurrent CNS depressants (e.g., benzodiazepines, alcohol): can enhance sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: may potentiate orthostatic hypotension.
  • Anticholinergic drugs: can worsen dry mouth and constipation.
  • Lithium: may increase risk of neurotoxicity.

Frequently Asked Questions

Matepil contains quetiapine, which is prescribed for schizophrenia, bipolar disorder (both manic and depressive phases), and as an adjunct treatment for major depressive disorder when additional therapeutic support is needed.

Quetiapine blocks several neurotransmitter receptors, including serotonin 5‑HT2A, dopamine D2, histamine H1 and adrenergic α1, while partially stimulating 5‑HT1A receptors. This combined activity helps balance dopamine and serotonin pathways, reducing psychotic symptoms and stabilising mood.

The specific dose of Matepil is determined by the prescribing clinician based on the individual’s diagnosis, severity of symptoms, age, and response to therapy. Dosage adjustments are made according to clinical judgement and patient tolerance.

Safety data for quetiapine in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and decisions are made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation antipsychotics, quetiapine (Matepil) generally has a lower risk of extrapyramidal symptoms but may cause more sedation and metabolic changes. It offers a broader therapeutic range, covering both psychotic and mood disorders, which can reduce the need for multiple agents.

Matepil should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency.

Matepil is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with water and follow the dosing schedule provided by the healthcare professional.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, tardive dyskinesia, severe hypotension, cardiac arrhythmias and the emergence or worsening of suicidal thoughts. Patients should be monitored closely for any of these adverse events.

Matepil is contraindicated in individuals with known hypersensitivity to quetiapine or any of its excipients. Caution is advised for patients with uncontrolled cardiovascular disease, severe hepatic impairment, or a history of neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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