Matic (Magaldrate)

Magaldrate is an antacid that acts on excess gastric acid to provide symptomatic relief in several gastrointestinal conditions.

• Heartburn: Reduces burning sensation by neutralizing stomach acid.
• Dyspepsia: Alleviates upper abdominal discomfort and fullness.
• Acid indigestion: Provides rapid relief from sour taste and discomfort after meals.
• Gastric ulcer: Helps maintain a less acidic environment to support ulcer healing.

• Magaldrate works by reacting directly with hydrochloric acid in the stomach to form magnesium chloride and aluminum hydroxide. This chemical reaction raises the gastric pH, thereby decreasing acidity. The resulting alkaline environment reduces irritation of the gastric mucosa and promotes symptom relief. The dual‑action of magnesium and aluminum components also provides a buffering effect that prolongs acid neutralization.

Magaldrate may cause adverse reactions, most of which are mild and transient.

Common Side Effects

• Constipation: Soft stools may become harder.
• Diarrhea: Loose stools may occur, especially with higher doses.
• Nausea: Mild stomach upset may be experienced.
• Flatulence: Increased gas production can cause discomfort.
• Metallic taste: A temporary metallic sensation in the mouth.

Serious or Rare Side Effects

• Hypermagnesemia: Elevated magnesium levels, particularly in renal impairment.
• Aluminum toxicity: Rare accumulation leading to bone or neurological effects.

When using Magaldrate, certain precautions should be observed to ensure safe and effective therapy.

• Renal impairment: Use with caution; monitor magnesium levels.
• Hepatic disease: Consider reduced dosing if liver function is compromised.
• Concomitant antacids: Avoid simultaneous use of multiple antacids to prevent excess alkalinity.
• Pediatric use: Safety and efficacy have not been established in children; use only if prescribed.
• Pregnancy and lactation: Safety has not been established; discuss risks with a healthcare professional.
• Store at ambient temperature: Keep below 25 °C, retain in original packaging, and protect from moisture.

Magaldrate can affect the absorption or effectiveness of several medicines; interactions are categorized by clinical significance.

Major Interactions (Avoid)

• Tetracycline antibiotics: Reduced absorption; separate administration by at least 2 hours.
• Fluoroquinolones (e.g., ciprofloxacin): Decreased bioavailability; avoid co‑administration.
• Iron salts: Chelation may impair iron uptake; stagger dosing.
• Digoxin: Increased serum levels; monitor cardiac function.
• Ketoconazole and other azole antifungals: Impaired absorption; avoid concurrent use.

Moderate Interactions (Monitor Closely)

• Levothyroxine: May decrease thyroid hormone absorption; check thyroid function tests.
• Warfarin: Potential alteration of anticoagulant effect; monitor INR.
• Other antacids or acid‑suppressing agents: Additive alkalizing effect; adjust dose if needed.