Matrifen (Fentanyl)

Fentanyl in Matrifen binds selectively to μ‑opioid receptors in the brain and spinal cord. This activation blocks the transmission of pain signals and alters the perception of pain, producing strong analgesic and sedative effects while the patch delivers the drug steadily over several days.

The specific dose of Matrifen is determined by the prescribing clinician based on the patient’s opioid tolerance, pain severity, and clinical condition. The prescriber selects the appropriate patch strength and duration, and any adjustments are made according to individual response and safety monitoring.

Fentanyl crosses the placenta and is excreted in breast milk, potentially causing respiratory depression in the fetus or infant. Use during pregnancy or lactation is generally discouraged unless the benefit outweighs the risk and no safer alternatives are available. Consultation with a specialist is essential.

To order Matrifen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Matrifen contains fentanyl, a highly potent synthetic opioid, similar to other fentanyl patches on the market. Compared with morphine or buprenorphine patches, fentanyl provides a faster onset and higher potency, allowing smaller patch sizes for equivalent analgesia, but it also requires careful monitoring for respiratory depression.

Store Matrifen at room temperature, below 25 °C, in its original sealed pouch. Keep the patch away from moisture, direct sunlight and heat sources. Do not expose to extreme temperatures, and handle with clean, dry hands to avoid contamination of the adhesive surface.

The patch is applied to a clean, dry, hair‑free area of the upper torso or upper arm. Press firmly for at least 30 seconds, then cover with a protective dressing if needed. The patch remains in place for the prescribed duration, usually 72 hours, after which it is removed and disposed of safely.

The most serious risks include respiratory depression, severe hypotension, opioid dependence, and rare but life‑threatening skin reactions. Patients should be educated on signs of overdose, such as shallow breathing or extreme drowsiness, and instructed to seek immediate medical attention if they occur.

Matrifen is contraindicated in patients with known hypersensitivity to fentanyl or patch components, those with severe respiratory insufficiency, untreated obstructive sleep apnea, or acute intoxication with alcohol or other central depressants. It should also be avoided in individuals taking MAO inhibitors within the past 14 days.