Product image of Maveral (Fluvoxamine Maleate) supplied by GNH India

Maveral

Active Ingredient:
Fluvoxamine Maleate
Origin:
EU

Maveral (Fluvoxamine Maleate)

Fluvoxamine Maleate, the active ingredient in Maveral, is a selective serotonin reuptake inhibitor presented as an oral tablet for oral use. It is prescribed for major depressive disorder, obsessive‑compulsive disorder, panic disorder and social anxiety in adult patients.

GNH India supplies Maveral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable logistics for global distribution.

Manufacturer / TM Owner

Viatris Italia S.R.L.

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Indications & Clinical Uses

Fluvoxamine, an SSRI, is used to treat several psychiatric conditions by enhancing serotonergic neurotransmission.

  • Major depressive disorder: alleviates depressive symptoms and improves mood.
  • Obsessive‑compulsive disorder: reduces compulsive thoughts and repetitive behaviors.
  • Panic disorder: decreases frequency and severity of panic attacks.
  • Social anxiety disorder: lessens social fear and avoidance behaviors.

How It Works

  • Fluvoxamine selectively inhibits the serotonin transporter (SERT) on presynaptic neurons, blocking reuptake of serotonin (5‑HT) from the synaptic cleft. This increases extracellular serotonin levels, enhancing serotonergic neurotransmission throughout central nervous system pathways involved in mood, anxiety and obsessive‑compulsive regulation.

Side Effects

Fluvoxamine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Headache: transient cranial discomfort.
  • Dry mouth: reduced salivary flow.
  • Dizziness: occasional light‑headedness.
  • Sexual dysfunction: decreased libido or delayed orgasm.

Serious or Rare Side Effects

  • Serotonin syndrome: agitation, hyperthermia, muscle rigidity.
  • Suicidal ideation: emergent thoughts of self‑harm, especially early in therapy.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety factors.

  • Dose adjustment: required in hepatic impairment.
  • Monitor: for emergence of suicidal thoughts, especially early in treatment.
  • Avoid: concurrent use with monoamine oxidase inhibitors.
  • Caution: in patients with renal dysfunction.
  • Pregnancy: risk unknown; weigh benefits versus potential fetal risk.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Fluvoxamine interacts with several drug classes; some combinations must be avoided while others require close monitoring.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome.
  • Thioridazine: can cause QT prolongation and cardiac arrhythmias.
  • Tramadol: increased risk of seizures and serotonin toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: fluvoxamine may enhance anticoagulant effect; monitor INR.
  • Carbamazepine: may reduce fluvoxamine plasma levels; adjust dose if needed.
  • Benzodiazepines: may increase sedation; observe patient response.

Frequently Asked Questions

Maveral, containing fluvoxamine maleate, is indicated for the treatment of major depressive disorder, obsessive‑compulsive disorder, panic disorder, and social anxiety disorder in adult patients. These conditions are managed by enhancing serotonergic activity in the brain.

Fluvoxamine selectively blocks the serotonin transporter (SERT), preventing reuptake of serotonin into presynaptic neurons. This raises serotonin levels in the synaptic cleft, improving neurotransmission in pathways that regulate mood, anxiety, and compulsive behaviors.

The appropriate dose of Maveral is individualized by the prescribing clinician based on the patient’s diagnosis, severity of symptoms, age, liver function, and response to therapy. Dosage adjustments may be required for hepatic impairment or drug interactions.

Safety data for fluvoxamine in pregnancy and lactation are limited. Clinicians should weigh potential benefits against uncertain risks and consider alternative therapies when possible. Breastfeeding mothers should discuss potential infant exposure with their healthcare provider.

To request Maveral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Maveral (fluvoxamine) and sertraline belong to the same SSRI class but differ in pharmacokinetic profiles and specific drug‑interaction potentials. Fluvoxamine has a stronger inhibition of certain cytochrome P450 enzymes, which may increase interactions, while sertraline is generally considered to have fewer metabolic interactions.

Maveral should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, direct sunlight and excessive heat to maintain potency throughout the shelf life.

Maveral is taken orally, usually once daily in the evening, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

The most serious risks include the potential for serotonin syndrome when combined with other serotonergic agents, emergence of suicidal thoughts or behaviors, especially during early treatment, and rare severe allergic reactions such as anaphylaxis.

Maveral is contraindicated in patients who are currently taking monoamine oxidase inhibitors, have a known hypersensitivity to fluvoxamine or any excipients, or have a history of severe serotonin syndrome. Caution is also advised for individuals with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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