Product image of Mavitalon (Diltiazem Hydrochloride) supplied by GNH India

Mavitalon

Active Ingredient:
Diltiazem Hydrochloride
Origin:
EU

Mavitalon (Diltiazem Hydrochloride)

Diltiazem Hydrochloride, the active ingredient in Mavitalon, is a calcium channel blocker presented as an oral tablet for systemic use. It is employed to lower elevated blood pressure and to relieve chest pain associated with chronic stable angina in adult patients.

GNH India supplies Mavitalon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

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Indications & Clinical Uses

Diltiazem Hydrochloride acts on the cardiovascular system to manage pressure‑related and ischemic conditions.

  • Hypertension: helps lower elevated arterial pressure in adult patients.
  • Chronic stable angina: reduces the frequency and severity of chest pain episodes.
  • Atrial flutter: assists in controlling ventricular rate during episodes of atrial flutter.

How It Works

  • Diltiazem Hydrochloride binds to L‑type calcium channels in cardiac myocytes and vascular smooth muscle, inhibiting calcium influx. This results in vasodilation of peripheral arteries and reduced myocardial contractility, leading to decreased systemic vascular resistance and lower heart rate, which together help control blood pressure and alleviate myocardial oxygen demand.

Side Effects

Common Side Effects

  • Headache: mild to moderate discomfort often occurring early in therapy.
  • Flushing: transient warmth and redness, especially of the face.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: sensation of light‑headedness, particularly when standing quickly.

Serious or Rare Side Effects

  • Bradycardia: abnormally slow heart rate that may require medical attention.
  • Severe hypotension: marked drop in blood pressure causing faintness or shock.
  • Heart block: impairment of electrical conduction through the heart.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor blood pressure: check regularly to ensure therapeutic response.
  • Assess cardiac function: evaluate for existing conduction abnormalities.
  • Use caution in hepatic impairment: dose adjustments may be needed.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Review concomitant beta‑blocker therapy: increased risk of bradycardia.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Diltiazem Hydrochloride may interact with several medicines.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): can raise diltiazem levels.
  • Concurrent beta‑blockers: may cause excessive bradycardia.
  • Digoxin: increased risk of digoxin toxicity.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce diltiazem effectiveness.
  • Macrolide antibiotics (e.g., erythromycin): may modestly increase plasma concentrations.

Frequently Asked Questions

Mavitalon contains diltiazem hydrochloride, which is prescribed to manage high blood pressure (hypertension) and to relieve chest pain caused by chronic stable angina. It may also be used to control heart rate in certain arrhythmias such as atrial flutter, as determined by a healthcare professional.

Diltiazem hydrochloride blocks L‑type calcium channels in the heart and blood vessels. By reducing calcium entry, it relaxes vascular smooth muscle, leading to vasodilation, and decreases the force of cardiac contraction, which together lower blood pressure and reduce the heart's oxygen demand during angina.

The appropriate dose of Mavitalon is individualized by the prescribing clinician based on the patient’s medical condition, response to therapy, and other medications. Dosage adjustments are made according to clinical guidelines and patient-specific factors.

Safety data for diltiazem hydrochloride in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mavitalon belongs to the calcium channel blocker class, which primarily causes vasodilation. Compared with ACE inhibitors or beta‑blockers, it may be preferred when a patient requires both blood pressure control and heart rate reduction, but the choice depends on individual clinical profiles and physician judgment.

Mavitalon should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from excess moisture and direct sunlight to maintain its stability and potency throughout its shelf life.

Mavitalon is taken orally, usually with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

The most serious risks include significant bradycardia, severe hypotension, and heart block, which can be life‑threatening. Patients should be monitored for symptoms such as fainting, dizziness, or unusually slow heartbeats, and seek immediate medical attention if they occur.

Mavitalon is contraindicated in patients with known hypersensitivity to diltiazem or any component of the formulation, those with severe sinus node dysfunction without a pacemaker, and individuals with second‑ or third‑degree atrioventricular block unless a pacemaker is in place.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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