Product image of Maxartan (Losartan Potassium, Hydrochlorothiazide) supplied by GNH India

Maxartan

Active Ingredient:
Losartan Potassium, Hydrochlorothiazide
Origin:
EU

Maxartan (Losartan Potassium, Hydrochlorothiazide)

Losartan potassium, the active ingredient in Maxartan, is an angiotensin II receptor blocker presented as a tablet for oral use. It is combined with hydrochlorothiazide, a thiazide diuretic, to treat hypertension in adult patients. It helps lower blood pressure by blocking the effects of angiotensin II and reducing fluid retention, offering a synergistic approach for patients requiring combined therapy.

GNH India supplies Maxartan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Sja Pharm Ltd

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Indications & Clinical Uses

Maxartan, a combination of an angiotensin II receptor blocker and a thiazide diuretic, is used to manage hypertension and related conditions.

  • Hypertension: lowers systolic and diastolic blood pressure in patients with primary hypertension.
  • Hypertension with fluid retention: provides additional diuretic effect to reduce excess extracellular fluid.
  • Hypertension in patients requiring combined therapy: offers convenient single‑tablet regimen for those needing both an ARB and a thiazide diuretic.

How It Works

  • Losartan potassium selectively blocks the AT1 receptors for angiotensin II, preventing vasoconstriction and aldosterone release, while hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal convoluted tubule, promoting diuresis and decreasing plasma volume. The combined actions result in reduced peripheral resistance and lower blood pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Increased urination.
  • Electrolyte disturbances such as low potassium.
  • Mild fatigue.

Serious or Rare Side Effects

  • Severe allergic reactions (e.g., rash, swelling, difficulty breathing).
  • Acute kidney injury or worsening renal function.
  • Significant hypotension leading to fainting.
  • Hyperkalemia, especially when used with potassium‑sparing agents.
  • Pancreatitis (rare).

Precautions & Warnings

Before initiating therapy, patients should be evaluated for renal function, electrolyte balance, and blood pressure control.

  • Monitor blood pressure: ensure adequate reduction without excessive hypotension.
  • Assess renal function: check serum creatinine and eGFR regularly.
  • Check electrolytes: especially potassium and sodium levels.
  • Use caution in severe liver disease: dose adjustments may be required.
  • Elderly patients: start at lower doses and monitor for orthostatic effects.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Maxartan may interact with several medicines that affect blood pressure, renal function, or electrolyte balance.

Major Interactions (Avoid)

  • ACE inhibitors or aliskiren: risk of additive hyperkalemia and renal impairment.
  • Potassium supplements or potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • NSAIDs (e.g., ibuprofen, naproxen): can blunt antihypertensive effect and affect kidney function.
  • Lithium: increased lithium levels and toxicity.
  • Dual renin‑angiotensin system blockade: heightened risk of adverse renal outcomes.

Moderate Interactions (Monitor Closely)

  • Other diuretics: may exacerbate electrolyte disturbances.
  • Antidiabetic agents: enhanced hypoglycemic effect.
  • Rifampin or other CYP inducers: may reduce losartan plasma concentrations.
  • Beta‑blockers: additive blood‑pressure lowering effect.
  • CYP2C9 inhibitors (e.g., fluconazole): may increase losartan levels.

Frequently Asked Questions

Maxartan is prescribed to treat high blood pressure (hypertension). It combines an angiotensin II receptor blocker with a thiazide diuretic, providing both vasodilation and fluid‑removal effects, which together help lower systolic and diastolic pressures in adult patients.

Losartan potassium blocks the AT1 receptors that bind angiotensin II, a hormone that normally causes blood vessels to narrow and stimulates aldosterone release. By preventing this binding, losartan promotes vessel relaxation and reduces fluid retention, contributing to lower blood pressure.

The dose of Maxartan is individualized by the prescribing clinician based on the patient’s blood‑pressure readings, kidney function, electrolyte status, and overall health. The prescriber will select the appropriate strength and titrate as needed to achieve target blood‑pressure goals.

The safety of Maxartan in pregnancy has not been established, and it is generally avoided unless the potential benefit outweighs the risk. Limited data exist for breastfeeding; therefore, clinicians usually recommend alternative antihypertensives that have a clearer safety profile.

To order Maxartan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Maxartan offers a single‑tablet solution that combines an ARB with a thiazide diuretic, which can simplify regimens compared with taking two separate drugs. Compared with ACE inhibitors, it has a lower incidence of cough, while the thiazide component adds diuretic benefit not present in many monotherapy ARBs.

Maxartan tablets should be stored at temperatures below 25 °C, in their original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps maintain its potency throughout its shelf life.

Maxartan is taken orally, usually once daily, with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include severe allergic reactions, significant drops in blood pressure (hypotension), acute kidney injury, and dangerous electrolyte imbalances such as hyperkalemia. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, fainting, or sudden changes in kidney function.

Maxartan should be avoided in individuals with known hypersensitivity to losartan, hydrochlorothiazide, or any component of the formulation. It is also contraindicated in patients with severe renal impairment, anuria, or those taking certain medications that could cause unsafe potassium elevations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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