Product image of Maxidrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone) supplied by GNH India

Maxidrol

Active Ingredient:
Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone
Origin:
EU

Maxidrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone)

Dexamethasone, neomycin sulfate and polymyxin B sulfate, the active ingredients in Maxidrol, are a corticosteroid and antibiotic combination presented as an ophthalmic solution for ocular use. It treats bacterial and inflammatory eye conditions such as conjunctivitis and post‑operative inflammation in adults and children.

GNH India supplies Maxidrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novartis Pharma S.A.S.

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Indications & Clinical Uses

Maxidrol is indicated for ocular conditions where inflammation and bacterial infection coexist.

  • Bacterial conjunctivitis: reduces bacterial load and associated inflammation, promoting faster symptom relief.
  • Post‑operative ocular inflammation: controls swelling and pain after eye surgery, aiding recovery.
  • Allergic conjunctivitis: diminishes allergic inflammation and discomfort in the conjunctiva.
  • Other inflammatory ocular conditions: provides anti‑inflammatory and antibacterial effects for various eye disorders.

How It Works

  • Dexamethasone binds glucocorticoid receptors, modulating gene expression to suppress inflammatory mediators. Neomycin binds the 30S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis. Polymyxin B interacts with the bacterial cell‑membrane lipopolysaccharide, increasing permeability and causing cell death. The combined actions deliver both anti‑inflammatory and broad‑spectrum antibacterial activity within the eye.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation upon instillation.
  • Transient blurred vision.
  • Mild ocular itching or redness.
  • Slight increase in intra‑ocular pressure.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling or difficulty breathing.
  • Corneal ulceration or secondary ocular infection.
  • Development of cataract with prolonged use.
  • Glaucoma or marked rise in intra‑ocular pressure.
  • Persistent visual disturbances.

Precautions & Warnings

Before using Maxidrol, consider the following precautions:

  • Pregnancy: consult a healthcare professional as safety has not been established.
  • Breastfeeding: discuss potential risks with a physician.
  • Contact lens wearers: avoid using the drops while lenses are in place.
  • Pre‑existing glaucoma or ocular hypertension: monitor intra‑ocular pressure regularly.
  • Concurrent systemic corticosteroid therapy: assess for additive systemic effects.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Maxidrol may interact with other ophthalmic agents.

Major Interactions (Avoid)

  • Systemic corticosteroids: may increase risk of systemic side effects.
  • Antiviral eye drops (e.g., ganciclovir): potential antagonism of anti‑inflammatory effect.
  • Other potent ophthalmic NSAIDs: heightened risk of corneal toxicity.

Moderate Interactions (Monitor Closely):\n- Anticholinergic eye drops: may affect pupil size and intra‑ocular pressure.

  • Ocular antihistamines: monitor for additive irritation.
  • Additional topical antibiotics: assess for overlapping toxicity.

Frequently Asked Questions

Maxidrol is an ophthalmic solution that combines a corticosteroid with two antibiotics. It is used to treat bacterial conjunctivitis, post‑operative ocular inflammation, allergic conjunctivitis, and other inflammatory eye conditions where infection and swelling coexist.

Dexamethasone acts as a glucocorticoid receptor agonist, suppressing inflammatory pathways in the eye. Neomycin inhibits bacterial protein synthesis by binding the 30S ribosomal subunit, while polymyxin B disrupts bacterial cell‑membrane integrity, leading to cell death. Together they provide anti‑inflammatory and broad‑spectrum antibacterial effects.

The dosing regimen for Maxidrol is determined by the prescribing clinician based on the specific indication, severity of the condition, and patient factors. The prescriber will provide detailed instructions on the number of drops, frequency, and duration of therapy.

Safety data for Maxidrol in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using this medication.

To order Maxidrol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team will then respond with pricing, availability, shipping details and any required import documentation.

Compared with single‑agent eye drops, Maxidrol offers both anti‑inflammatory and antibacterial activity in one formulation, reducing the need for multiple products. Alternatives may include separate corticosteroid and antibiotic drops, which can increase treatment complexity and cost.

Maxidrol should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any solution that appears discolored or contains particles.

Maxidrol is applied topically to the eye as directed by a healthcare professional. Typically, one or more drops are placed in the affected eye(s) at the prescribed frequency, avoiding contact with the tip of the bottle to maintain sterility.

Serious risks include severe allergic reactions such as anaphylaxis, corneal ulceration, secondary ocular infections, cataract formation, and significant increases in intra‑ocular pressure that may lead to glaucoma. Patients should seek immediate medical attention if they experience vision changes, severe pain, or signs of infection.

Maxidrol should not be used by individuals with known hypersensitivity to dexamethasone, neomycin, polymyxin B, or any component of the formulation. It is also contraindicated in patients with viral eye infections such as herpes simplex keratitis, as corticosteroids may worsen the condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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