Product image of Maxigra (Sildenafil Citrate) supplied by GNH India

Maxigra

Active Ingredient:
Sildenafil Citrate
Origin:
EU

Maxigra (Sildenafil Citrate)

Sildenafil Citrate, the active ingredient in Maxigra, is a phosphodiesterase type 5 (PDE5) inhibitor presented as an oral tablet for oral use. It treats erectile dysfunction and pulmonary arterial hypertension in adult patients.
GNH India supplies Maxigra as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Sildenafil Citrate acts on the nitric‑oxide/cGMP pathway to improve vascular smooth‑muscle relaxation in specific disease states.

  • Erectile dysfunction: improves the ability to achieve and maintain an erection sufficient for sexual activity.
  • Pulmonary arterial hypertension: helps lower pulmonary arterial pressure and enhances exercise capacity.

How It Works

  • Sildenafil Citrate selectively inhibits phosphodiesterase type 5 enzymes, preventing the breakdown of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels lead to relaxation of smooth muscle in the corpus cavernosum and pulmonary vasculature, increasing blood flow and facilitating erection or reducing pulmonary arterial pressure.

Side Effects

Sildenafil may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate pain often occurring shortly after dosing.
  • Flushing: warmth and redness of the face or upper chest.
  • Dyspepsia: indigestion or upset stomach.
  • Nasal congestion: stuffy or runny nose.
  • Visual disturbances: blurred vision or changes in colour perception.

Serious or Rare Side Effects

  • Priapism: prolonged erection lasting more than four hours, requiring urgent medical attention.
  • Sudden hearing loss: abrupt decrease or loss of hearing, sometimes accompanied by tinnitus.
  • Cardiovascular events: rare cases of myocardial infarction or stroke, especially in patients with pre‑existing heart disease.

Precautions & Warnings

Before prescribing Maxigra, clinicians should evaluate patient history and potential risk factors.

  • Cardiovascular assessment: ensure the patient can tolerate sexual activity without undue risk.
  • Nitrate therapy: avoid concurrent use due to risk of severe hypotension.
  • Retinal disorders: use with caution in patients with inherited retinal diseases.
  • Alcohol consumption: limit intake as it may exacerbate hypotensive effects.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Sildenafil interacts with several drug classes that can modify its safety profile.

Major Interactions (Avoid)

  • Nitrates (e.g., nitroglycerin): may cause dangerous drops in blood pressure.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase sildenafil plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Alpha‑blockers (e.g., doxazosin): may enhance hypotensive effects.
  • CYP3A4 inducers (e.g., rifampin): may reduce efficacy of sildenafil.
  • Other PDE5 inhibitors: concurrent use can increase risk of adverse events.

Frequently Asked Questions

Maxigra contains sildenafil citrate and is prescribed to treat erectile dysfunction and pulmonary arterial hypertension. In erectile dysfunction it helps achieve and maintain an erection, while in pulmonary arterial hypertension it lowers pulmonary arterial pressure and improves exercise capacity.

Sildenafil citrate selectively blocks phosphodiesterase type 5, an enzyme that degrades cyclic guanosine monophosphate (cGMP). By preserving cGMP, it promotes smooth‑muscle relaxation in the corpus cavernosum and pulmonary vessels, increasing blood flow to the penis or lungs.

The appropriate dose of Maxigra is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and any concomitant medications. Patients should follow the dosing instructions provided by their healthcare professional.

The safety of sildenafil citrate in pregnancy or while breastfeeding has not been established. It is generally not recommended for use in these populations unless the potential benefit justifies the potential risk, as assessed by a healthcare provider.

To order Maxigra, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Maxigra (sildenafil) shares the same mechanism as other PDE5 inhibitors such as tadalafil and vardenafil. Differences lie in onset of action, duration of effect, and dosing frequency. Sildenafil typically acts within 30‑60 minutes and lasts up to 4‑6 hours, whereas tadalafil may last up to 36 hours.

Maxigra tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, direct sunlight and excessive heat to maintain product stability throughout its shelf life.

Maxigra is taken orally, usually with water, about 30‑60 minutes before sexual activity for erectile dysfunction or as prescribed for pulmonary arterial hypertension. It may be taken with or without food, but a high‑fat meal can delay its onset.

Serious risks include priapism (a painful erection lasting more than four hours), sudden hearing loss, and rare cardiovascular events such as myocardial infarction or stroke, particularly in patients with pre‑existing heart disease. Immediate medical attention is required if these occur.

Maxigra should not be used by individuals taking nitrates, those with severe uncontrolled hypertension, recent history of stroke or heart attack, or patients with certain retinal disorders. Contra‑indications are determined by the prescribing clinician based on the patient’s overall health profile.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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