Product image of Maxitrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone) supplied by GNH India

Maxitrol

Active Ingredient:
Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone
Origin:
EU

Maxitrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone)

Neomycin / Polymyxin B / Dexamethasone, the active ingredient in Maxitrol, is a corticosteroid/aminoglycoside antibiotic/polymyxin antibiotic combination presented as an ophthalmic suspension for ocular use. It treats bacterial conjunctivitis, post‑operative ocular inflammation, allergic conjunctivitis and other inflammatory eye conditions by reducing inflammation and eliminating susceptible bacteria.

GNH India supplies Maxitrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Sia Novartis Baltics

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Indications & Clinical Uses

  • Maxitrol is used to manage ocular conditions involving bacterial infection and inflammation.
  • Bacterial conjunctivitis: reduces bacterial load and alleviates redness, discharge and discomfort.
  • Post‑operative ocular inflammation: controls inflammation and helps prevent infection after eye surgery.
  • Allergic conjunctivitis: diminishes allergic inflammatory response and provides symptomatic relief.

How It Works

  • Maxitrol combines three agents that act at different sites. Dexamethasone binds glucocorticoid receptors, modulating gene transcription to suppress inflammatory mediators. Neomycin binds the 30 S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis. Polymyxin B interacts with the bacterial cell membrane, disrupting its integrity and causing cell death. The synergistic action provides both anti‑inflammatory and broad‑spectrum antibacterial effects in the eye.

Side Effects

Adverse ocular reactions may occur with Maxitrol use.

Common Side Effects

  • Stinging or burning sensation upon instillation
  • Transient blurred vision
  • Eye redness (hyperemia)
  • Increased intra‑ocular pressure
  • Mild ocular irritation or itching
  • Tearing

Serious or Rare Side Effects

  • Allergic reaction such as swelling, rash or urticaria
  • Secondary ocular infection or worsening of infection
  • Corneal ulceration or thinning
  • Development of cataract with prolonged use
  • Glaucoma due to sustained pressure rise
  • Systemic corticosteroid effects from excessive absorption

Precautions & Warnings

  • Before prescribing Maxitrol, consider the following precautions.
  • Assess for viral or fungal eye infection: avoid use if such infection is present.
  • Monitor intra‑ocular pressure: especially in patients with glaucoma or ocular hypertension.
  • Check for hypersensitivity: discontinue if any allergic response to the components occurs.
  • Limit duration of therapy: use only under ophthalmologist supervision to prevent complications.
  • Pregnancy and lactation: safety not established; use only if potential benefit outweighs risk.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Maxitrol may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Systemic corticosteroids: may increase risk of systemic glucocorticoid effects.
  • Concurrent ophthalmic antibiotics: can lead to additive ocular toxicity.
  • Anticholinergic eye drops: may reduce the anti‑inflammatory efficacy.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation.
  • Contact lens wear: lenses can trap the suspension, increasing exposure and risk of irritation.

Frequently Asked Questions

Maxitrol is an ophthalmic suspension indicated for the treatment of bacterial conjunctivitis, post‑operative ocular inflammation, allergic conjunctivitis and other inflammatory eye conditions where both antibacterial and anti‑inflammatory actions are required.

The formulation combines three mechanisms: dexamethasone activates glucocorticoid receptors to suppress inflammatory mediators; neomycin binds the bacterial 30 S ribosomal subunit, halting protein synthesis; and polymyxin B disrupts bacterial cell membranes, leading to cell death. Together they provide simultaneous anti‑inflammatory and antibacterial effects.

The dosing regimen for Maxitrol is determined by the prescribing eye‑care professional based on the specific condition, severity and patient response. The prescriber will provide detailed instructions on the number of drops, frequency and duration of therapy.

Safety data for Maxitrol in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified health‑care provider.

To order Maxitrol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent eye drops, Maxitrol offers a combined corticosteroid and broad‑spectrum antibacterial effect, reducing the need for multiple products. Alternatives may include separate steroid and antibiotic drops, but Maxitrol simplifies therapy and can improve adherence when both actions are clinically indicated.

Store Maxitrol at room temperature, preferably below 25 °C, in the original container. Protect the suspension from light, moisture and extreme temperatures. Keep the bottle tightly closed when not in use and discard any product that appears discolored or contains particles.

Maxitrol is applied as an ocular drop. The patient should wash hands, tilt the head back, pull down the lower eyelid to form a pocket, and instill the prescribed number of drops without touching the tip of the bottle to the eye or surrounding structures.

Serious risks include allergic reactions, secondary ocular infections, corneal ulceration, increased intra‑ocular pressure leading to glaucoma, cataract formation with prolonged use, and systemic corticosteroid effects if absorbed in significant amounts.

Maxitrol should be avoided in patients with known hypersensitivity to any of its components, in eyes with viral or fungal infections, and in individuals where corticosteroid use is contraindicated, such as uncontrolled glaucoma or certain systemic infections, unless directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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