Product image of Maxitrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone) supplied by GNH India

Maxitrol

Active Ingredient:
Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone
Origin:
EU

Maxitrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone)

Neomycin, Polymyxin B and Dexamethasone, the active ingredients in Maxitrol, are a combination antibiotic/corticosteroid presented as a 3%/0.1%/0.5% ophthalmic suspension for ocular use. It treats bacterial and inflammatory eye conditions in adults and children as prescribed.

GNH India supplies Maxitrol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sia Novartis Baltics

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Indications & Clinical Uses

Maxitrol is used to manage bacterial and inflammatory eye disorders.

  • Bacterial conjunctivitis: reduces bacterial load and promotes resolution of infection.
  • Allergic or inflammatory conjunctivitis: suppresses inflammation and relieves redness and discomfort.
  • Iritis and iridocyclitis: diminishes intra‑ocular inflammation and pain.
  • Keratitis: controls infection and inflammation of the cornea.
  • Blepharitis: helps clear bacterial colonisation and reduces eyelid swelling.

How It Works

  • Neomycin interferes with bacterial protein synthesis, while Polymyxin B disrupts the bacterial cell‑membrane, providing broad‑spectrum antibacterial activity. Dexamethasone binds to intracellular glucocorticoid receptors, modulating gene expression to suppress the release of inflammatory mediators, thereby reducing ocular inflammation and immune response.

Side Effects

Adverse reactions may occur with ocular use of Maxitrol.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Temporary blurred vision.
  • Mild conjunctival hyperemia.
  • Foreign body sensation.
  • Tearing or increased lacrimation.

Serious or Rare Side Effects

  • Secondary ocular infection or fungal overgrowth.
  • Elevated intra‑ocular pressure leading to glaucoma.
  • Corneal ulceration or perforation.
  • Allergic contact dermatitis of the eyelid.
  • Systemic absorption causing adrenal suppression (very rare).

Precautions & Warnings

Before using Maxitrol, consider the following safety points.

  • Pregnancy: safety not established; use only if potential benefit outweighs risk.
  • Breastfeeding: unknown; weigh benefits against possible infant exposure.
  • Pre‑existing glaucoma: monitor intra‑ocular pressure closely.
  • Viral eye infections (e.g., herpes simplex): avoid as steroids may worsen disease.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Maxitrol may interact with other ophthalmic agents.

Major Interactions (Avoid)

  • Concurrent use of other topical corticosteroids: may increase risk of ocular hypertension.
  • Systemic immunosuppressants: could potentiate infection risk.

Moderate Interactions (Monitor Closely)

  • Topical NSAIDs: may increase irritation.
  • Anticholinergic eye drops: could affect tear film stability.
  • Other antibiotic eye drops: assess for additive antimicrobial effect and resistance.

Frequently Asked Questions

Maxitrol is indicated for bacterial conjunctivitis, allergic or inflammatory conjunctivitis, iritis, keratitis, and blepharitis. It combines antibacterial agents with a corticosteroid to clear infection and reduce ocular inflammation, providing symptomatic relief in these eye conditions.

Neomycin and Polymyxin B act as broad‑spectrum antibiotics; Neomycin inhibits bacterial protein synthesis, while Polymyxin B disrupts the bacterial cell membrane. Dexamethasone binds glucocorticoid receptors, suppressing inflammatory gene expression and reducing swelling, redness, and pain in the eye.

The specific dosing schedule for Maxitrol is determined by the prescribing clinician based on the severity of the infection or inflammation, patient age, and response to therapy. Patients should follow the prescriber’s instructions and the product label for proper administration.

Safety data for Maxitrol in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant. Healthcare providers will assess individual risk before prescribing.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent antibiotic drops, Maxitrol offers the added benefit of a corticosteroid to control inflammation. Against steroid‑only drops, it provides antibacterial protection, reducing the risk of secondary infection. Choice depends on the clinical presentation and physician judgment.

Maxitrol should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and discard any product that appears discoloured or contains particles.

Maxitrol is applied as an ophthalmic suspension. The patient tilts the head back, pulls down the lower eyelid, instills the prescribed number of drops into the conjunctival sac, and closes the eye gently for a few seconds. Contact lenses should be removed before use and re‑inserted after the recommended waiting period.

Serious risks include secondary ocular infections, increased intra‑ocular pressure that may lead to glaucoma, corneal ulceration, and rare systemic effects such as adrenal suppression. Patients should report persistent pain, vision changes, or signs of infection promptly.

Maxitrol is contraindicated in patients with known hypersensitivity to any of its components, active viral eye infections (e.g., herpes simplex keratitis), and in those with uncontrolled glaucoma unless closely monitored. It should also be avoided in individuals where steroid use is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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