Product image of Maxitrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone) supplied by GNH India

Maxitrol

Active Ingredient:
Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone
Origin:
EU

Maxitrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone)

Neomycin sulfate, Polymyxin B sulfate and Dexamethasone, the active ingredients in Maxitrol, are a combination antibiotic and corticosteroid presented as an ophthalmic preparation for ocular use. It treats bacterial eye infections and associated inflammation in patients requiring topical therapy.

GNH India supplies Maxitrol as a licensed, GDP‑compliant international pharmaceutical supplier, delivering the product to hospitals, pharmacies, transplant centres and clinics worldwide, with established quality‑assured logistics and regulatory support. The company ensures consistent availability across EU and other markets through rigorous quality control and reliable supply chain management.

Manufacturer / TM Owner

Novartis Poland Sp. Z O. O.

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Indications & Clinical Uses

Maxitrol, a combination antibiotic and corticosteroid eye drop, is used to manage bacterial ocular infections and inflammatory conditions.

  • Bacterial conjunctivitis: reduces bacterial load and alleviates associated redness and discharge.
  • Keratitis: treats infection of the cornea while controlling inflammation.
  • Post‑operative ocular inflammation: minimizes swelling and pain after eye surgery.
  • Blepharitis: clears bacterial involvement and reduces eyelid inflammation.

How It Works

  • Dexamethasone binds glucocorticoid receptors, inhibiting phospholipase A2 and suppressing pro‑inflammatory cytokine production, thereby reducing ocular inflammation. Neomycin, an aminoglycoside, binds the bacterial 30S ribosomal subunit, blocking protein synthesis and leading to bacterial death. Polymyxin B interacts with the lipopolysaccharide layer of Gram‑negative bacteria, disrupting cell‑membrane integrity and causing rapid bacterial lysis. The glucocorticoid effect also stabilizes lysosomal membranes and reduces capillary permeability, while the antibiotics provide broad coverage against Gram‑positive and Gram‑negative organisms commonly implicated in ocular infections.

Side Effects

Adverse ocular reactions may occur with Maxitrol use.

Common Side Effects

  • Burning or stinging sensation
  • Transient blurred vision
  • Mild itching of the eye

Serious or Rare Side Effects

  • Increased intra‑ocular pressure
  • Secondary bacterial or fungal infection
  • Severe allergic reaction (angioedema or anaphylaxis)

Precautions & Warnings

Before using Maxitrol, consider the following precautions.

  • Avoid use in patients with known hypersensitivity to any component: discontinue immediately if a reaction occurs.
  • Monitor intra‑ocular pressure during prolonged therapy: schedule regular ophthalmic examinations.
  • Do not use on viral or fungal eye infections: may worsen the condition.
  • Limit duration as prescribed: prolonged use can increase risk of cataract formation.
  • Avoid contact lens wear during treatment: remove lenses before instillation.
  • Store at room temperature (below 25 °C): keep in original container, protect from moisture and light.

Avoid Interactions

Maxitrol may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Concurrent use of other topical corticosteroids: may cause additive systemic absorption and increased intra‑ocular pressure.
  • Systemic aminoglycoside therapy: potential additive nephrotoxicity and ototoxicity.
  • Live vaccines: immunosuppression from the corticosteroid may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: may increase risk of corneal thinning.
  • Anticholinergic eye drops: possible reduced efficacy of Maxitrol.
  • Systemic CYP450 inducers: may slightly reduce dexamethasone levels.

Frequently Asked Questions

Maxitrol is a prescription ophthalmic solution that combines an antibiotic and a corticosteroid. It is indicated for the treatment of bacterial eye infections such as conjunctivitis, keratitis, and blepharitis, and for reducing inflammation after eye surgery or trauma.

Neomycin and polymyxin B act as antibiotics: neomycin interferes with bacterial protein synthesis, while polymyxin B disrupts the cell membrane of Gram‑negative organisms. Dexamethasone is a glucocorticoid that binds intracellular receptors, suppressing inflammatory mediators and reducing swelling, redness, and pain.

The dosing regimen for Maxitrol is determined by the prescribing eye‑care professional based on the severity of infection, the specific condition being treated, and patient factors. The prescriber will provide detailed instructions on the number of drops, frequency, and duration of therapy.

Safety data for Maxitrol in pregnancy and lactation are limited. Because dexamethasone is a corticosteroid and the antibiotics may be systemically absorbed, the product should be used only if the potential benefit justifies any potential risk. The prescriber should evaluate each case individually.

To request Maxitrol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will respond with pricing, availability, shipping details and any required import documentation.

Compared with single‑agent antibiotic drops, Maxitrol offers both antimicrobial activity and anti‑inflammatory control in one formulation, which can simplify treatment regimens. Unlike steroid‑only drops, it also addresses the underlying infection. Choice of therapy depends on the clinical picture, microbial susceptibility and physician preference.

Store Maxitrol at room temperature, below 25 °C, in its original container. Protect the bottle from moisture and direct light. Do not freeze. After opening, keep the dropper tip clean and replace the cap tightly to maintain sterility.

Maxitrol is applied topically to the eye. The prescribed number of drops is placed into the conjunctival sac, usually several times a day. Patients should wash their hands before use, avoid touching the tip to the eye or any surface, and wait a few minutes before applying other eye medications.

Serious risks include a rise in intra‑ocular pressure that can lead to glaucoma, secondary infections such as fungal or bacterial overgrowth, and severe allergic reactions that may present as angioedema or anaphylaxis. Prompt medical attention is required if any of these events occur.

Maxitrol should be avoided in individuals with known hypersensitivity to neomycin, polymyxin B, dexamethasone, or any excipients. It is also contraindicated for viral or fungal eye infections, and for patients with uncontrolled glaucoma or a history of steroid‑induced ocular hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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