Maxitrol (Neomycin Sulfate, Polymyxin B Sulfate, Dexamethasone)

Neomycin interferes with bacterial protein synthesis by binding the 30S ribosomal subunit, while Polymyxin B disrupts bacterial cell‑membrane integrity, leading to cell death. Dexamethasone binds intracellular glucocorticoid receptors, altering gene transcription to suppress inflammatory mediators and immune‑cell activity. Together they eliminate infection and control inflammation.

The dosing regimen for Maxitrol is determined by the prescribing clinician based on the specific indication, severity of infection, and patient factors. Typically, a few drops are instilled into the affected eye(s) at the frequency indicated on the prescription, and the treatment duration is set by the healthcare professional.

Safety data for Maxitrol in pregnancy and lactation are limited. Because it contains a corticosteroid and antibiotics, the product should only be used if the potential benefit justifies any potential risk to the fetus or infant. The prescriber should evaluate the individual situation and discuss alternatives if necessary.

To order Maxitrol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then replies with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with single‑agent antibiotic drops, Maxitrol offers the advantage of combined antibacterial coverage (Neomycin and Polymyxin B) plus anti‑inflammatory action from Dexamethasone, reducing the need for separate steroid therapy. However, the presence of a corticosteroid requires careful monitoring for intra‑ocular pressure rise, which may not be an issue with antibiotics alone.

Maxitrol should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and avoid freezing. Do not use the product if the solution appears discolored or contains particles.

Maxitrol is applied as an eye drop. The patient should wash their hands, tilt the head back, pull down the lower eyelid to create a small pocket, and instill the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow absorption, and any excess liquid can be wiped away.

Serious risks include severe allergic reactions such as angio‑edema or anaphylaxis, corneal ulceration or perforation, significant elevation of intra‑ocular pressure that can lead to glaucoma, and secondary infections with resistant organisms. Patients should be instructed to seek immediate medical attention if they experience sudden vision loss, intense eye pain, or signs of an allergic reaction.

Maxitrol should be avoided in individuals with known hypersensitivity to Neomycin, Polymyxin B, Dexamethasone, or any excipients in the formulation. It is also contraindicated in eyes with viral (e.g., herpes simplex) or fungal infections, as the steroid component may exacerbate these conditions. Caution is advised in children and in patients with a history of glaucoma or cataract.