Product image of Maxolon High Dose (Metoclopramide Hydrochloride Bp) supplied by GNH India

Maxolon High Dose

Active Ingredient:
Metoclopramide Hydrochloride Bp
Origin:
EU

Maxolon High Dose (Metoclopramide Hydrochloride Bp)

Metoclopramide, the active ingredient in Maxolon High Dose, is a dopamine antagonist presented as an intravenous injection for use in the treatment of nausea, vomiting and gastroparesis in adult patients. It works by blocking dopamine receptors in the chemoreceptor trigger zone and enhancing gastrointestinal motility.

GNH India supplies Maxolon High Dose as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Amdipharm Uk Limited

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Indications & Clinical Uses

Metoclopramide is employed to manage conditions that involve nausea, vomiting or delayed gastric emptying.

  • Nausea and vomiting: reduces the frequency and severity of acute and chronic episodes.
  • Gastroparesis: improves gastric emptying and alleviates related symptoms.
  • Postoperative nausea and vomiting: prevents and treats nausea after surgical procedures.

How It Works

  • Metoclopramide acts as an antagonist of dopamine D2 receptors in the chemoreceptor trigger zone of the brain, diminishing the vomiting reflex. In the gastrointestinal tract it blocks dopamine receptors and stimulates muscarinic receptors, which enhances coordinated gastric contractions, accelerates gastric emptying, and promotes intestinal transit.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: a sense of inner tension or inability to stay still.
  • Diarrhea: increased frequency of loose stools.
  • Dry mouth: reduced salivation leading to a parched feeling.
  • Headache: mild to moderate head pain.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or rigidity.
  • Tardive dyskinesia: persistent, irreversible facial or tongue movements.
  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Severe allergic reaction: rash, itching, swelling, or breathing difficulty.

Precautions & Warnings

When using Metoclopramide, clinicians should consider several safety measures.

  • Assess renal and hepatic function: adjust use in impairment.
  • Monitor for signs of extrapyramidal reactions: especially in the elderly.
  • Evaluate for depression or suicidal thoughts: dopamine antagonism may affect mood.
  • Use caution in patients with seizure disorders: may lower seizure threshold.
  • Store below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Metoclopramide can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticholinergic agents: may reduce pro‑kinetic effect.
  • MAO inhibitors: increase risk of hypertensive crisis.
  • CNS depressants (e.g., opioids, benzodiazepines): enhance sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., codeine, tramadol): may increase plasma levels.
  • Antihistamines: can potentiate drowsiness.
  • Digoxin: may increase serum concentrations.

Frequently Asked Questions

Maxolon High Dose is used to treat nausea and vomiting of various origins, manage gastroparesis by improving gastric emptying, and prevent or treat postoperative nausea and vomiting following surgical procedures.

Metoclopramide blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the vomiting reflex, and stimulates gastrointestinal motility by enhancing coordinated gastric contractions, which speeds up stomach emptying.

The specific dose and infusion rate of Maxolon High Dose are determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Dosing should follow the prescriber’s instructions.

Safety data for metoclopramide in pregnancy and lactation are limited. Use only if the potential benefit justifies any potential risk to the fetus or infant, and always under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with other dopamine antagonists, metoclopramide offers both anti‑emetic and pro‑kinetic actions, making it useful for conditions involving delayed gastric emptying. It differs from serotonin antagonists, which lack the pro‑kinetic effect.

Store Maxolon High Dose below 25 °C in its original packaging, protecting it from light and moisture. Do not freeze or expose the product to extreme temperatures.

Maxolon High Dose is given by intravenous injection, typically as a slow infusion under clinical supervision. Administration techniques and infusion rates are determined by the treating physician.

Serious risks include extrapyramidal reactions such as dystonia, tardive dyskinesia, and neuroleptic malignant syndrome, as well as severe allergic reactions. Immediate medical attention is required if these occur.

Patients with known hypersensitivity to metoclopramide, those with a history of severe extrapyramidal reactions, or individuals with uncontrolled epilepsy should avoid using Maxolon High Dose, unless a physician determines it is essential.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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