Product image of Maxolon (Metoclopramide Hydrochloride Bp) supplied by GNH India

Maxolon

Active Ingredient:
Metoclopramide Hydrochloride Bp
Origin:
EU

Maxolon (Metoclopramide Hydrochloride Bp)

Metoclopramide Hydrochloride, the active ingredient in Maxolon, is a dopamine antagonist presented as an oral dosage form for oral use. It is employed to alleviate nausea and vomiting, improve gastric emptying in gastroparesis, and reduce reflux symptoms, as well as to prevent chemotherapy‑induced nausea in adult patients.
GNH India supplies Maxolon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Amdipharm Uk Limited

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Indications & Clinical Uses

Maxolon, a dopamine antagonist, is used in several gastrointestinal and oncologic conditions where nausea, delayed gastric emptying, or reflux are problematic.

  • Nausea and vomiting: reduces the frequency and severity of acute, postoperative or medication‑induced nausea.
  • Gastroparesis: enhances gastric motility to improve stomach emptying and relieve related symptoms.
  • Gastro‑oesophageal reflux disease (GERD): decreases reflux episodes by promoting gastric emptying.
  • Chemotherapy‑induced nausea: prevents or lessens nausea associated with cytotoxic cancer treatments.

How It Works

  • Metoclopramide Hydrochloride blocks dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the central vomiting stimulus, while simultaneously stimulating gastrointestinal motility through cholinergic pathways. It also exhibits weak antagonism of 5‑HT3 receptors, contributing to its antiemetic effect, and promotes coordinated gastric contractions that facilitate gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to severe. Awareness of these effects helps clinicians monitor patients appropriately.

Common Side Effects

  • Drowsiness or fatigue
  • Restlessness or anxiety
  • Diarrhea or abdominal cramps
  • Headache
  • Dry mouth
  • Dizziness

Serious or Rare Side Effects

  • Extrapyramidal symptoms, including dystonia or akathisia
  • Tardive dyskinesia with long‑term use
  • Neuroleptic malignant syndrome
  • Severe allergic reactions such as anaphylaxis
  • Cardiac arrhythmias or QT prolongation
  • Depression or suicidal thoughts

Precautions & Warnings

Before prescribing Maxolon, clinicians should consider several safety measures.

  • Assess patient history: evaluate prior movement disorders or neurological conditions.
  • Monitor for extrapyramidal reactions: watch for muscle rigidity, tremor, or abnormal movements.
  • Use caution in renal impairment: dose adjustment may be required.
  • Avoid in patients with known hypersensitivity to metoclopramide or other dopamine antagonists.
  • Pregnancy and lactation: weigh potential benefits against risks; limited data are available.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Metoclopramide can interact with various medications, altering efficacy or safety.

Major Interactions (Avoid)

  • Antipsychotics such as haloperidol: increased risk of severe extrapyramidal symptoms.
  • Monoamine oxidase inhibitors (MAOIs): may precipitate hypertensive crises.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): raise metoclopramide plasma levels.
  • Other dopamine antagonists: additive central nervous system effects.
  • QT‑prolonging agents: heightened risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Opioids: may enhance sedation and respiratory depression.
  • Antihistamines and CNS depressants: increase drowsiness.
  • Alcohol: potentiates central nervous system depression.
  • Serotonergic drugs (e.g., SSRIs, tramadol): monitor for serotonin syndrome.
  • Anticholinergic agents: may diminish pro‑kinetic effect.

Frequently Asked Questions

Maxolon is prescribed to manage nausea and vomiting from various causes, to improve gastric emptying in gastroparesis, to reduce reflux episodes in gastro‑oesophageal reflux disease, and to prevent nausea associated with chemotherapy. It works by targeting the central vomiting center and enhancing gastrointestinal motility.

Metoclopramide Hydrochloride blocks dopamine D2 receptors in the chemoreceptor trigger zone, which reduces the brain’s vomiting signal. It also stimulates gastrointestinal smooth‑muscle activity through cholinergic pathways, promoting coordinated gastric contractions and faster stomach emptying. Weak 5‑HT3 antagonism adds to its anti‑nausea effect.

The appropriate dose of Maxolon is determined by the prescribing healthcare professional based on the patient’s condition, age, renal function and response to therapy. Dosage regimens may differ for acute nausea, chronic gastroparesis or chemotherapy‑induced nausea, and should always follow the prescriber’s instructions.

Safety data for Maxolon in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss the risks and alternatives with their healthcare provider.

To request Maxolon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with other antiemetics such as ondansetron (a 5‑HT3 antagonist) or prochlorperazine (another dopamine antagonist), Maxolon offers both central anti‑vomiting activity and pro‑kinetic effects that enhance gastric emptying. Choice of therapy depends on the underlying cause of nausea, patient tolerance, and the side‑effect profile of each medication.

Maxolon should be stored at ambient temperature, below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Maxolon is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed unless otherwise directed by a healthcare professional. Dosing frequency and timing depend on the specific indication and the prescriber’s guidance.

Serious risks include extrapyramidal reactions such as dystonia or akathisia, tardive dyskinesia with long‑term use, neuroleptic malignant syndrome, severe allergic reactions, and cardiac arrhythmias like QT prolongation. Patients should be monitored closely for any of these symptoms, and the drug should be discontinued if they occur.

Maxolon is contraindicated in individuals with known hypersensitivity to metoclopramide or other dopamine antagonists, in patients with pheochromocytoma, and in those with a history of severe extrapyramidal reactions. Caution is also advised for patients with gastrointestinal obstruction, perforation, or hemorrhage.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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