Product image of Mayesta (Isotretinoin) supplied by GNH India

Mayesta

Active Ingredient:
Isotretinoin
Origin:
EU

Mayesta (Isotretinoin)

Isotretinoin, the active ingredient in Mayesta, is a retinoid presented as an oral formulation for oral use. It is prescribed for severe nodular acne and acne vulgaris in patients who have not responded to conventional therapies. The drug is formulated to meet European Union pharmaceutical standards and is distributed under a prescription‑only status.

GNH India supplies Mayesta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to Good Distribution Practice, ensuring product integrity during storage and transport across global markets.

Manufacturer / TM Owner

Alfasigma España, S.L.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Isotretinoin is a systemic retinoid that targets severe acne disorders by modulating skin cell growth and sebum production.

  • Severe nodular acne: reduces inflammatory nodules and prevents formation of new lesions.
  • Acne vulgaris: decreases both inflammatory and non‑inflammatory lesions, improving overall skin appearance.
  • Recalcitrant acne: provides therapeutic benefit when standard topical and oral antibiotics have failed.

How It Works

  • Isotretinoin binds to nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in keratinocytes and sebaceous gland cells. This interaction down‑regulates genes involved in sebocyte differentiation, leading to reduced gland size and sebum output. It also normalizes follicular keratinization and exerts anti‑inflammatory effects by modulating cytokine production, collectively addressing the pathogenic mechanisms of severe acne.

Side Effects

Isotretinoin may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dry skin and mucous membranes
  • Cheilitis (cracked lips)
  • Dry eyes or irritation
  • Elevated triglyceride levels
  • Transient headache
  • Skin peeling or desquamation

Serious or Rare Side Effects

  • Severe depression or suicidal ideation
  • Pancreatitis
  • Significant liver injury
  • Pseudotumor cerebri (intracranial hypertension)
  • Teratogenic birth defects
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

Before initiating isotretinoin therapy, several precautions should be observed to minimize risks.

  • Pregnancy contraindication: drug is classified as Category X and must not be used during pregnancy.
  • Contraception requirement: women of childbearing potential must use effective contraception throughout treatment and for one month after discontinuation.
  • Liver function monitoring: obtain baseline liver enzymes and repeat periodically during therapy.
  • Lipid profile monitoring: assess baseline triglycerides and cholesterol, repeat as needed.
  • Vitamin A intake restriction: avoid concurrent high‑dose vitamin A supplements.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and light.

Avoid Interactions

Isotretinoin can interact with other medicines, affecting safety or effectiveness.

Major Interactions (Avoid)

  • Tetracycline antibiotics: combined use increases risk of intracranial hypertension.
  • Vitamin A supplements: additive toxicity may lead to severe hypervitaminosis A.
  • Phenobarbital and other enzyme inducers: may reduce isotretinoin plasma levels, diminishing efficacy.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: isotretinoin may reduce hormonal contraceptive effectiveness; additional barrier methods are advised.
  • Anticonvulsants (e.g., carbamazepine, phenytoin): may lower isotretinoin concentrations, requiring monitoring.
  • Statins: concurrent use may increase risk of liver enzyme elevation; monitor hepatic function.

Frequently Asked Questions

Mayesta contains isotretinoin, a retinoid indicated for the treatment of severe nodular acne and moderate to severe acne vulgaris. It is typically prescribed when patients have not achieved adequate control with topical agents or oral antibiotics.

Isotretinoin acts by binding to nuclear retinoic acid receptors, which reduces the size and activity of sebaceous glands, lowers sebum production, normalizes follicular keratinization, and provides anti‑inflammatory effects. These actions together address the key pathogenic factors of severe acne.

The dosage of Mayesta is individualized by the prescribing clinician based on the patient’s weight, severity of disease, and laboratory monitoring. The prescriber determines the appropriate strength and regimen; no standard dose is provided here.

Mayesta is classified as pregnancy Category X. It is contraindicated in pregnancy because it can cause severe birth defects. Women of child‑bearing potential must use effective contraception, and the drug should not be used while breastfeeding.

To request Mayesta, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Mayesta (isotretinoin) is a systemic retinoid, offering a disease‑modifying effect that topical retinoids, antibiotics or hormonal agents cannot achieve. It provides long‑term remission after a finite course, whereas many alternatives require continuous use and may have lower efficacy in severe cases.

Mayesta should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and ensure the packaging remains sealed until use.

Mayesta is taken orally, usually with food to improve absorption and reduce gastrointestinal discomfort. The tablet or capsule is swallowed whole with a full glass of water; it should not be crushed, chewed, or divided unless specifically instructed by a healthcare professional.

The most serious risks include severe depression or suicidal thoughts, pancreatitis, significant liver injury, intracranial hypertension (pseudotumor cerebri), and teratogenic effects leading to birth defects. Prompt medical attention is required if any of these symptoms arise.

Mayesta should not be used by pregnant women, individuals planning to become pregnant, or those who cannot commit to effective contraception. Patients with uncontrolled hyperlipidaemia, severe liver disease, or a history of severe psychiatric disorders should avoid the drug unless a specialist advises otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Isotretinoin

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT