Product image of Mayesta (Isotretinoin) supplied by GNH India

Mayesta

Active Ingredient:
Isotretinoin
Origin:
EU

Mayesta (Isotretinoin)

Isotretinoin, the active ingredient in Mayesta, is a retinoid presented as an oral formulation for oral use. It is indicated for the treatment of severe recalcitrant nodular acne in patients who have not responded to conventional therapies.

GNH India supplies Mayesta as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alfasigma España, S.L.

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Indications & Clinical Uses

  • Mayesta (isotretinoin) belongs to the retinoid class and is used to treat severe forms of acne vulgaris.
  • Severe nodular acne: reduces inflammatory lesions and prevents new nodule formation.
  • Acne conglobata: helps clear extensive, deep‑seated lesions.
  • Recalcitrant acne: provides therapeutic benefit when other systemic treatments have failed.

How It Works

  • Isotretinoin binds to nuclear retinoic acid receptors, modulating gene expression that leads to decreased sebaceous gland size and reduced sebum production. It also normalizes follicular keratinization and exerts anti‑inflammatory effects, collectively limiting the bacterial environment that drives acne lesions.

Side Effects

Isotretinoin is associated with a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dry skin and mucous membranes.
  • Cheilitis (cracked lips).
  • Xerosis (dry eyes).
  • Increased photosensitivity.
  • Headache.
  • Myalgia.

Serious or Rare Side Effects

  • Severe depression or suicidal ideation.
  • Inflammatory bowel disease.
  • Elevated liver enzymes.
  • Hypertriglyceridemia.
  • Pseudotumor cerebri.
  • Teratogenicity (birth defects).

Precautions & Warnings

Isotretinoin requires careful monitoring and adherence to safety guidelines.

  • Pregnancy: contraindicated; ensure effective contraception before, during, and after therapy.
  • Laboratory monitoring: baseline and periodic liver function tests and lipid profiles.
  • Vitamin A supplementation: avoid concurrent use to prevent additive toxicity.
  • Sun exposure: limit and use broad‑spectrum sunscreen.
  • Psychiatric symptoms: monitor for depression or mood changes.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Isotretinoin may interact with several medications, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Tetracyclines: risk of intracranial hypertension.
  • Vitamin A supplements: additive teratogenic and toxicity risk.
  • Systemic corticosteroids: may diminish isotretinoin effectiveness.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in contraceptive reliability.
  • Anticoagulants (e.g., warfarin): monitor INR for changes.
  • Lamotrigine: increased risk of severe skin reactions.

Frequently Asked Questions

Mayesta contains isotretinoin and is used to treat severe recalcitrant nodular acne, including acne conglobata and other forms of acne that have not responded to standard therapies.

Isotretinoin binds to retinoic acid receptors, reducing the size and activity of sebaceous glands, decreasing sebum production, normalizing follicular keratinization, and providing anti‑inflammatory effects that together limit acne lesion development.

The specific dose of Mayesta is determined by the prescribing clinician based on the patient’s weight, severity of acne, and individual response. Dosing should follow the prescriber’s instructions.

Mayesta is classified as Pregnancy Category X and is contraindicated in pregnancy due to a high risk of birth defects. It is also not recommended while breastfeeding because isotretinoin can be excreted in milk.

To order Mayesta, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Mayesta (isotretinoin) is a systemic retinoid offering a unique mechanism that reduces sebum production, unlike antibiotics or topical agents that target bacteria or inflammation alone. It is generally reserved for severe, treatment‑resistant acne due to its efficacy and safety profile.

Mayesta should be stored at ambient temperature, below 25 °C, in its original packaging, protected from moisture and direct light to maintain stability.

Mayesta is taken orally, usually with a full glass of water. The exact administration schedule, such as with meals or on an empty stomach, should follow the prescribing clinician’s guidance.

The most serious risks include teratogenicity (birth defects), severe depression or suicidal thoughts, inflammatory bowel disease, significant liver enzyme elevation, hypertriglyceridemia, and rare cases of pseudotumor cerebri.

Mayesta should not be used by pregnant or nursing women, patients with known hypersensitivity to isotretinoin or other retinoids, individuals with uncontrolled hyperlipidemia or liver disease, and those taking contraindicated medications such as tetracyclines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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