Product image of Maygace Altas Dosis (Megestrol Acetate) supplied by GNH India

Maygace Altas Dosis

Active Ingredient:
Megestrol Acetate
Origin:
EU

Maygace Altas Dosis (Megestrol Acetate)

Megestrol acetate, the active ingredient in Maygace Altas Dosis, is a progestin presented as an oral tablet for oral use. It is employed to stimulate appetite and as hormonal therapy in patients with cachexia associated with AIDS or cancer, and in certain hormone‑sensitive cancers.

GNH India supplies Maygace Altas Dosis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, ensuring quality, regulatory compliance and reliable delivery across global markets through established distribution networks and after‑sales support.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

  • Maygace Altas Dosis (megestrol acetate) is used in the management of conditions involving hormonal modulation and appetite stimulation.
  • Cachexia associated with AIDS: improves appetite and promotes weight gain in patients with AIDS‑related wasting.
  • Cachexia in cancer patients: helps increase caloric intake and stabilise body weight during oncologic therapy.
  • Advanced breast cancer: provides antineoplastic activity in hormone‑responsive tumors.
  • Endometrial cancer: used as hormonal therapy for disease control.

How It Works

  • Megestrol acetate is a synthetic progestin that binds to progesterone receptors, modulating gene transcription and inhibiting tumor cell proliferation. The receptor activation also influences hypothalamic pathways that increase appetite and promote weight gain, while exerting antineoplastic effects in hormone‑sensitive cancers.

Side Effects

Megestrol acetate may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Nausea or vomiting
  • Weight gain and fluid retention
  • Fatigue or weakness
  • Menstrual irregularities or amenorrhea
  • Mild hyperglycemia
  • Edema of the lower extremities

Serious or Rare Side Effects

  • Thromboembolic events (deep vein thrombosis, pulmonary embolism)
  • Adrenal insufficiency or cortisol suppression
  • Severe hyperglycemia or new‑onset diabetes
  • Allergic reactions including rash or anaphylaxis
  • Cushingoid syndrome with characteristic fat redistribution

Precautions & Warnings

  • When prescribing Maygace Altas Dosis, clinicians should consider several safety measures.
  • Monitor weight and nutritional status: assess effectiveness and adjust therapy as needed.
  • Assess thromboembolic risk: avoid use in patients with active clotting disorders.
  • Evaluate blood glucose: monitor diabetic patients closely for hyperglycemia.
  • Review hormone‑sensitive tumor status: consider alternative therapies if disease progresses.
  • Adjust dose in hepatic impairment: use lower doses and monitor liver function.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Megestrol acetate can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase drug exposure.
  • Anticoagulants (e.g., warfarin): heightened risk of thrombosis.
  • Insulin or oral hypoglycemics: risk of severe hypoglycemia.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce therapeutic effect.
  • Systemic corticosteroids: additive risk of fluid retention and hyperglycemia.

Frequently Asked Questions

Maygace Altas Dosis contains megestrol acetate and is indicated for appetite stimulation in cachexia associated with AIDS or cancer, as well as for hormonal therapy in advanced breast cancer and endometrial cancer. It helps improve nutritional status and can provide antineoplastic effects in hormone‑sensitive tumors.

Megestrol acetate is a synthetic progestin that binds to progesterone receptors, altering gene expression that suppresses tumor growth in hormone‑responsive cancers. Receptor activation also influences hypothalamic pathways, increasing appetite and promoting weight gain, which is beneficial in cachectic patients.

The appropriate dose of Maygace Altas Dosis is determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Dosage may vary for appetite stimulation versus oncologic indications, and adjustments are made according to clinical judgment.

Safety of megestrol acetate in pregnancy and lactation has not been established. Because it is a hormonal agent, it is generally avoided in pregnant or nursing women unless the potential benefit outweighs the potential risk, and it should be used only under specialist supervision.

To order Maygace Altas Dosis, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Megestrol acetate is often compared with medroxyprogesterone acetate, another synthetic progestin. Both agents stimulate appetite, but megestrol acetate typically shows a stronger effect on weight gain and has additional antineoplastic activity, whereas medroxyprogesterone may have a more favorable side‑effect profile for some patients.

Store Maygace Altas Dosis at room temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Maygace Altas Dosis is taken orally. The tablet should be swallowed whole with a glass of water, preferably with food to reduce gastrointestinal discomfort, unless the prescriber provides alternative instructions.

The most serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, adrenal insufficiency due to cortisol suppression, and severe hyperglycemia that may precipitate diabetic complications. Patients should be monitored closely for signs of these conditions.

Maygace Altas Dosis should be avoided in individuals with known hypersensitivity to megestrol acetate, active thromboembolic disease, uncontrolled diabetes, or in pregnant women unless absolutely necessary. Clinicians should also exercise caution in patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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