Product image of Mcp- Sf (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Mcp- Sf

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Mcp- Sf (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide, the active ingredient in Mcp- Sf, is a dopamine antagonist presented as an injectable solution for intramuscular and intravenous use. It is employed to control nausea, vomiting and to enhance gastric motility in patients requiring rapid symptom relief.

GNH India supplies Mcp- Sf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Metoclopramide acts on the dopaminergic and serotonergic pathways to control emesis and improve gastrointestinal motility.

  • Nausea and vomiting: reduces the frequency and severity of acute episodes in diverse clinical settings.
  • Postoperative nausea and vomiting: prevents and treats nausea following surgical procedures.
  • Gastroparesis: facilitates gastric emptying and alleviates related discomfort.

How It Works

  • Metoclopramide antagonizes dopamine D2 receptors in the chemoreceptor trigger zone, diminishing the central vomiting stimulus, while simultaneously acting as a 5‑HT4 agonist to stimulate acetylcholine release, thereby enhancing gastrointestinal smooth‑muscle contractility and accelerating gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: a sense of inner tension or inability to stay still.
  • Diarrhea: increased frequency of loose stools.
  • Dry mouth: reduced salivation leading to a parched feeling.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: involuntary muscle movements or rigidity.
  • Tardive dyskinesia: persistent, potentially irreversible facial or limb movements.
  • Neuroleptic malignant syndrome: life‑threatening fever, muscle rigidity, and autonomic instability.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for known safety concerns.

  • Renal or hepatic impairment: adjust therapy based on organ function.
  • Extrapyramidal monitoring: observe for signs of muscle rigidity or abnormal movements.
  • Lowest effective dose: use the minimal dose required to achieve therapeutic benefit.
  • Hypersensitivity: discontinue if allergic reactions occur.
  • Pregnancy: avoid unless clearly needed, as safety data are limited.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Metoclopramide can interact with several drug classes, influencing efficacy or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (high‑potency): heightened extrapyramidal effects.
  • CNS depressants: additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Opioids: may increase risk of constipation and reduced gastric motility.
  • Antihistamines: potential enhancement of drowsiness.
  • SSRIs or other serotonergic agents: monitor for serotonin syndrome.

Frequently Asked Questions

Mcp- Sf contains metoclopramide, which is prescribed to manage nausea and vomiting, prevent postoperative nausea and vomiting, and treat gastroparesis by improving stomach emptying. These indications are supported by clinical guidelines for acute and postoperative emesis as well as delayed gastric motility.

Metoclopramide blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing the vomiting reflex. It also stimulates serotonin 5‑HT4 receptors, enhancing acetylcholine release that promotes coordinated contractions of the gastrointestinal tract, thereby accelerating gastric emptying.

The specific dose of Mcp- Sf is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal function. Healthcare professionals follow local prescribing information to select the appropriate amount and frequency for each indication.

Safety data for metoclopramide in pregnancy are limited, and the drug is classified as a pregnancy category with unknown risk. It should only be used if the potential benefit justifies any possible risk to the fetus. Breastfeeding mothers should consult their physician, as the drug may be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Metoclopramide differs from other antiemetics such as ondansetron, which primarily blocks serotonin 5‑HT3 receptors. Metoclopramide’s dual action on dopamine D2 antagonism and 5‑HT4 agonism provides both central anti‑emetic effects and pro‑kinetic activity, making it useful for conditions involving delayed gastric emptying.

Mcp- Sf should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperature fluctuations to maintain stability and potency.

Mcp- Sf is supplied as an injectable solution for intramuscular or intravenous administration. The route, rate, and duration of injection are determined by the prescribing clinician, who follows standard aseptic techniques and monitors the patient for any immediate adverse reactions.

Serious risks include extrapyramidal symptoms such as acute dystonia, tardive dyskinesia, and neuroleptic malignant syndrome, which can be life‑threatening. Patients should be monitored closely for muscle rigidity, fever, autonomic instability, or any signs of severe allergic reaction.

Mcp- Sf is contraindicated in patients with known hypersensitivity to metoclopramide or any component of the formulation, as well as in individuals with a history of seizure disorders, pheochromocytoma, or severe gastrointestinal obstruction. Caution is also advised for patients with Parkinson’s disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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