Product image of Mcp- Sf (Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Mcp- Sf

Active Ingredient:
Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Mcp- Sf (Metoclopramide Hydrochloride Monohydrate)

Metoclopramide Hydrochloride Monohydrate, the active ingredient in Mcp- Sf, is a dopamine antagonist (antiemetic, gastro‑prokinetic) presented as an injectable for intramuscular and intravenous use. It treats nausea, vomiting and gastroparesis in adult patients.

GNH India supplies Mcp- Sf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

  • Metoclopramide acts on the dopaminergic pathways that trigger nausea and on gastrointestinal motility, making it useful for several related conditions.
  • Nausea: reduces the frequency and severity of nausea episodes.
  • Vomiting: controls acute and chemotherapy‑induced vomiting.
  • Gastroparesis: enhances gastric emptying and alleviates related symptoms.

How It Works

  • Metoclopramide competitively blocks dopamine D2 receptors in the chemoreceptor trigger zone, diminishing nausea signals, while simultaneously stimulating muscarinic receptors in the gastrointestinal tract to increase motility and accelerate gastric emptying.

Side Effects

Metoclopramide may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: inner sense of unease or agitation.
  • Diarrhea: loose, frequent stools.

Serious or Rare Side Effects

  • Extrapyramidal reactions: involuntary muscle movements or rigidity.
  • Tardive dyskinesia: persistent, irreversible facial or limb movements.
  • Neuroleptic malignant syndrome: rare, life‑threatening reaction with fever and muscle rigidity.

Precautions & Warnings

  • Before using Metoclopramide, several safety considerations should be observed.
  • Assess renal function: adjust use in patients with impaired kidney function.
  • Monitor for extrapyramidal symptoms: watch for involuntary movements during therapy.
  • Use with caution in depression: may worsen depressive symptoms.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Limit duration to ≤12 days for nausea/vomiting: reduces risk of tardive dyskinesia.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Metoclopramide can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Antipsychotics (e.g., haloperidol): antagonistic effect reduces therapeutic benefit.
  • MAO inhibitors: may precipitate hypertensive crisis.
  • CYP2D6 inhibitors: increase metoclopramide plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Opioids: additive central nervous system depression.
  • Anticholinergics: may diminish pro‑kinetic activity of metoclopramide.

Frequently Asked Questions

Mcp- Sf contains metoclopramide, which is prescribed to manage nausea, control vomiting—including chemotherapy‑induced episodes—and to treat gastroparesis by improving stomach emptying. It is used in adult patients when these symptoms affect quality of life or treatment outcomes.

Metoclopramide blocks dopamine D2 receptors in the brain’s chemoreceptor trigger zone, reducing nausea signals, while stimulating muscarinic receptors in the gastrointestinal tract to increase motility. This dual action helps suppress vomiting and promotes faster gastric emptying.

The dosage of Mcp- Sf is determined by the prescribing clinician based on the patient’s condition, severity, and route of administration. Healthcare professionals adjust the amount and frequency to achieve the desired therapeutic effect while minimizing risk.

Safety of metoclopramide in pregnancy or while breastfeeding has not been definitively established. Clinicians weigh potential benefits against possible risks and may limit use to situations where the expected benefit justifies exposure.

To request Mcp- Sf, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Metoclopramide differs from many antiemetics by also enhancing gastrointestinal motility, whereas agents like ondansetron act primarily on serotonin receptors. For patients with delayed gastric emptying, metoclopramide offers the added benefit of pro‑kinetic activity, but it carries a distinct side‑effect profile that must be considered.

Mcp- Sf should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain stability and potency.

Mcp- Sf is supplied as an injectable solution for intramuscular or intravenous administration. The route, rate and site of injection are selected by the healthcare professional according to the clinical indication and patient needs.

Serious risks include extrapyramidal reactions such as dystonia, tardive dyskinesia—a potentially irreversible movement disorder—and neuroleptic malignant syndrome, a rare but life‑threatening condition characterized by fever, muscle rigidity and autonomic instability.

Metoclopramide is contraindicated in individuals with known hypersensitivity to the drug, those with pheochromocytoma, and patients with a history of seizure disorders or severe depression. It should also be avoided in infants under one month of age.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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