Product image of Meaverin (Mepivacaine Hydrochloride) supplied by GNH India

Meaverin

Active Ingredient:
Mepivacaine Hydrochloride
Origin:
EU

Meaverin (Mepivacaine Hydrochloride)

Mepivacaine Hydrochloride, the active ingredient in Meaverin, is a local anesthetic presented as a sterile solution for epidural, intradermal and intravenous use. It provides reversible nerve blockade for minor surgical, dental and regional analgesia procedures in adult patients.
GNH India supplies Meaverin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Meaverin is a local anesthetic that acts on peripheral nerve sodium channels to produce reversible loss of sensation.

  • Minor surgical procedures: enables pain‑free operating fields for brief surgeries.
  • Dental procedures: provides infiltration anesthesia for routine dental work.
  • Epidural analgesia: delivers regional pain relief during labor or postoperative periods.
  • Diagnostic procedures: allows surface anesthesia for skin biopsies or minor examinations.

How It Works

  • Mepivacaine Hydrochloride produces a reversible blockade of voltage‑gated sodium channels in neuronal membranes, preventing the initiation and propagation of nerve impulses. By stabilising the neuronal membrane, it temporarily inhibits depolarisation, resulting in localized loss of sensation without affecting systemic consciousness.

Side Effects

Adverse reactions may occur following administration of Meaverin.

Common Side Effects

  • Injection site pain: mild discomfort at the injection site.
  • Transient numbness: temporary loss of sensation in the treated area.
  • Mild dizziness: brief sensation of light‑headedness.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm that may require monitoring.
  • Seizure: rare central nervous system excitation.
  • Methemoglobinemia: abnormal hemoglobin that reduces oxygen delivery.

Precautions & Warnings

Use Meaverin with caution and observe recommended safety measures.

  • Allergy assessment: verify no known hypersensitivity to amide‑type local anesthetics.
  • Cardiovascular status: apply cautiously in patients with conduction disorders.
  • Dosage limits: adhere to the maximum recommended dose set by the prescriber.
  • Concurrent CNS depressants: monitor for additive sedative effects.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Consider potential drug interactions when using Meaverin.

Major Interactions (Avoid)

  • Class I antiarrhythmic agents (e.g., quinidine, procainamide): may enhance cardiotoxicity.
  • Beta‑blockers: increase risk of bradycardia.

Moderate Interactions (Monitor Closely)

  • General anesthetics: may potentiate central nervous system depression.
  • Opioids: additive sedative effect may occur.
  • Monoamine oxidase inhibitors: possible increased neurotoxicity.

Frequently Asked Questions

Meaverin is a sterile solution of Mepivacaine Hydrochloride used to provide local anesthesia for minor surgical and dental procedures, as well as for epidural analgesia during labor or postoperative pain management. It works by temporarily blocking nerve signal transmission in the targeted area.

Mepivacaine Hydrochloride blocks voltage‑gated sodium channels on neuronal membranes, preventing the initiation and propagation of action potentials. This reversible inhibition stops nerve impulse transmission, producing a localized loss of sensation without affecting consciousness.

The appropriate dose of Meaverin is determined by the prescribing clinician based on the specific procedure, patient weight, and clinical context. Dosage recommendations are provided in the product labeling and must be individualized for each patient.

Safety data for Mepivacaine Hydrochloride in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and under close medical supervision.

To order Meaverin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Mepivacaine Hydrochloride offers a rapid onset similar to lidocaine but with a slightly longer duration of action and less vasodilatory effect, often reducing the need for a vasoconstrictor. It is an amide‑type anesthetic, providing reliable nerve block for short‑ to medium‑duration procedures.

Store Meaverin at ambient temperature, preferably below 25 °C, in its original packaging. Protect the solution from direct light, moisture and extreme temperature fluctuations. Ensure the container is sealed when not in use to maintain sterility.

Meaverin is supplied as a sterile injectable solution and can be administered via epidural, intradermal or intravenous routes. The injection technique follows standard aseptic procedures, and the volume injected is determined by the prescriber according to the intended anesthetic effect.

Serious adverse events, though rare, include cardiac arrhythmias, seizures, and methemoglobinemia. Patients should be monitored for signs of cardiovascular instability, central nervous system excitation, or abnormal oxygen saturation, and immediate medical intervention should be available.

Meaverin should be avoided in individuals with a known hypersensitivity to Mepivacaine, other amide‑type local anesthetics, or any component of the formulation. It is also contraindicated in patients with severe cardiac conduction disorders or uncontrolled arrhythmias unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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