Product image of Mebendazole Aurobindo (Mebendazole) supplied by GNH India

Mebendazole Aurobindo

Active Ingredient:
Mebendazole
Origin:
EU

Mebendazole Aurobindo (Mebendazole)

Mebendazole, the active ingredient in Mebendazole Aurobindo, is an anthelmintic (benzimidazole) presented as an oral tablet for the treatment of intestinal worm infections in children and adults. It works by disrupting the parasite’s ability to absorb glucose, leading to its death and clearance from the gastrointestinal tract.

GNH India supplies Mebendazole Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets EU quality standards and is available for bulk procurement.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

Mebendazole is an anthelmintic used to treat common intestinal helminth infections.

  • Ascariasis: eliminates Ascaris lumbricoides worms, reducing intestinal infestation and associated symptoms.
  • Hookworm infection: eradicates Ancylostoma duodenale and Necator americanus, relieving anemia and gastrointestinal discomfort.
  • Trichuriasis: clears Trichuris trichiura (whipworm) infection, improving bowel function.
  • Enterobiasis: removes Enterobius vermicularis (pinworm), preventing itching and secondary infection.

How It Works

  • Mebendazole binds to β‑tubulin in helminths, inhibiting microtubule polymerization. This disruption impairs glucose uptake and intracellular transport, leading to depletion of energy stores, immobilization and death of the parasite. The selective affinity for parasite tubulin over mammalian cells provides a favorable safety profile for oral administration.

Side Effects

Adverse reactions to Mebendazole are generally mild but can vary in frequency and severity.

Common Side Effects

  • Abdominal pain: mild discomfort in the stomach region.
  • Nausea: feeling of queasiness or urge to vomit.
  • Diarrhea: loose or watery stools.
  • Headache: mild to moderate head pain.
  • Dizziness: transient light‑headed sensation.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Agranulocytosis: severe reduction in white blood cells.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: skin blistering and mucosal involvement.

Precautions & Warnings

When using Mebendazole, certain precautions should be observed to ensure safety and effectiveness.

  • Pregnancy: safety not established; avoid use unless benefit outweighs risk.
  • Breastfeeding: unknown excretion; consider alternatives or monitor infant.
  • Liver disease: use with caution; monitor hepatic function.
  • Pediatric use: dosage must be determined by a healthcare professional.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original packaging.

Avoid Interactions

Mebendazole may interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Cimetidine: may increase plasma levels of mebendazole, raising toxicity risk.
  • Antifungal azoles (e.g., ketoconazole): can inhibit metabolism, leading to higher exposure.
  • Cyclosporine: potential for increased mebendazole concentrations.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced effectiveness reported; consider additional contraception.
  • Warfarin: possible alteration of anticoagulant effect; monitor INR.
  • Antacids containing aluminum or magnesium: may affect absorption; separate dosing by at least 2 hours.

Frequently Asked Questions

Mebendazole Aurobindo is an oral anthelmintic indicated for the treatment of common intestinal worm infections such as ascariasis, hookworm infection, trichuriasis and enterobiasis. It is used in both pediatric and adult patients to eliminate the parasites and relieve associated gastrointestinal symptoms.

Mebendazole interferes with the parasite’s microtubule formation by binding to β‑tubulin, which blocks glucose uptake and essential intracellular transport. The resulting energy depletion immobilizes the helminth, leading to its death and removal from the gastrointestinal tract.

The dosage of mebendazole is determined by the prescribing healthcare professional based on the specific infection, patient age, weight and clinical condition. Patients should follow the prescriber’s instructions and the product label; no standard dose is provided here.

Safety of mebendazole during pregnancy has not been established, and it is generally avoided unless the potential benefit justifies the risk. Information on excretion in breast milk is limited; therefore, caution is advised and alternative therapies may be considered for nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mebendazole belongs to the benzimidazole class and is distinguished by its specific inhibition of parasite tubulin, offering a broad spectrum against several nematodes. Compared with drugs such as albendazole, it has a similar mechanism but may differ in pharmacokinetics, dosing frequency and regulatory approvals in certain regions.

Store the tablets at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid exposing it to extreme heat or humidity.

Mebendazole Aurobindo is administered orally, usually with a glass of water. The tablets should be taken on an empty stomach unless the prescriber advises otherwise, and the full course should be completed even if symptoms improve early.

Serious adverse events, although rare, include liver toxicity, severe reduction in white blood cell count (agranulocytosis), and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs of jaundice, unexplained fever, rash or breathing difficulty.

Mebendazole should be avoided in individuals with known hypersensitivity to the drug or other benzimidazoles. It is also contraindicated in patients where the prescriber determines that the potential risks outweigh the benefits, such as certain severe liver conditions or during early pregnancy without a compelling indication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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