Product image of Mebendazole Marel (Mebendazole) supplied by GNH India

Mebendazole Marel

Active Ingredient:
Mebendazole
Origin:
EU

Mebendazole Marel (Mebendazole)

Mebendazole, the active ingredient in Mebendazole Marel, is a benzimidazole anthelmintic presented as an oral dosage form for oral use. It treats intestinal helminth infections such as roundworm, hookworm and whipworm in both children and adults.

GNH India supplies Mebendazole Marel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Marel B.V.

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Indications & Clinical Uses

Mebendazole is an anthelmintic medication used to treat common intestinal worm infections.

  • Roundworm (Ascaris lumbricoides): eliminates adult parasites and reduces egg shedding.
  • Hookworm (Ancylostoma duodenale, Necator americanus): eradicates infection and relieves gastrointestinal symptoms.
  • Whipworm (Trichuris trichiura): clears the parasite and improves bowel function.

How It Works

  • Mebendazole binds selectively to parasite β‑tubulin, disrupting microtubule polymerisation. This impairs glucose uptake and other essential metabolic processes, leading to depletion of energy stores and eventual death of the helminth.

Side Effects

Adverse reactions to mebendazole are generally mild but can vary in frequency and severity.

Common Side Effects

  • Abdominal pain: mild discomfort in the stomach area.
  • Nausea: feeling of queasiness.
  • Diarrhoea: loose or watery stools.
  • Headache: mild to moderate head pain.
  • Dizziness: transient light‑headedness.
  • Rash: mild skin irritation.

Serious or Rare Side Effects

  • Hepatotoxicity: signs of liver injury such as jaundice.
  • Agranulocytosis: severe reduction in white blood cells.
  • Severe allergic reaction: swelling, breathing difficulty, or hives.
  • Stevens‑Johnson syndrome: serious skin blistering.
  • Blood dyscrasias: abnormal blood counts.
  • Persistent vomiting: ongoing severe nausea and vomiting.

Precautions & Warnings

When using mebendazole, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use as safety data are limited.
  • Breastfeeding: discuss potential risks with a physician.
  • Liver disease: monitor liver function if underlying hepatic conditions exist.
  • Drug interactions: review concomitant medications for possible interactions.
  • Age considerations: dosage adjustments may be required for children.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mebendazole may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Cimetidine: may increase mebendazole plasma levels.
  • Cyclosporine: potential for enhanced toxicity.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., carbamazepine): may reduce mebendazole effectiveness.
  • Warfarin: monitor INR for possible changes.
  • Rifampicin: may lower mebendazole concentrations.
  • Oral contraceptives: advise on alternative contraception methods.

Frequently Asked Questions

Mebendazole Marel is used to treat common intestinal worm infections, specifically roundworm, hookworm and whipworm. It works by eliminating the parasites from the gastrointestinal tract, helping to relieve symptoms such as abdominal pain, diarrhoea and nutritional deficiencies.

Mebendazole binds to the β‑tubulin of helminths, preventing microtubule formation. This disrupts glucose uptake and other vital cellular functions, leading to energy depletion and death of the parasite within the intestine.

The dosage of Mebendazole Marel is determined by the prescribing healthcare professional based on the specific infection, patient age and weight. Only a qualified prescriber should set the appropriate regimen.

Safety data for mebendazole in pregnancy are limited, so it should only be used if the potential benefit outweighs the risk and after consulting a healthcare provider. Breastfeeding mothers should also seek medical advice before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mebendazole belongs to the benzimidazole class and is effective against a broad range of nematodes. Compared with alternatives such as albendazole, it has a similar spectrum but may differ in dosing frequency and pharmacokinetic profile, which can influence choice based on patient factors and local resistance patterns.

Store the product at temperatures below 25 °C in its original packaging. Keep it away from moisture, direct sunlight and excessive heat to maintain stability and potency.

Mebendazole Marel is taken orally, usually with water. The tablet should be swallowed whole and can be taken with or without food, unless the prescribing clinician advises otherwise.

Serious adverse events, although rare, include liver toxicity, severe allergic reactions such as Stevens‑Johnson syndrome, and blood disorders like agranulocytosis. Patients should seek immediate medical attention if they experience symptoms such as jaundice, rash, fever or unexplained bleeding.

Individuals with known hypersensitivity to mebendazole or any benzimidazole compounds should avoid the product. Caution is also advised for patients with severe liver disease, and the medication should only be used in pregnancy or breastfeeding after thorough medical evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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